Margatoxin;(Synonyms: 玛格斑蝎毒素) 纯度: 99.36%
Margatoxin 是一种 α-KTx 蝎毒素，一种高亲和力的 Kv1.3 抑制剂，Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道，Kd 值分别为 6.4 pM，4.2 nM。Margatoxin 是一种 39 个氨基酸的肽，是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的，广泛用于离子通道研究。
Margatoxin Chemical Structure
CAS No. : 145808-47-5
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 100 μg | ￥1500 | In-stock | |
| 500 μg | ￥4600 | In-stock | |
| 1 mg | ￥6800 | In-stock | |
| 5 mg | ; | 询价 | ; |
| 10 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
| 生物活性 |
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. |
IC50 Target |
Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1] |
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| 体内研究 (In Vivo) |
Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
4178.95 |
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| Formula |
C178H286N52O50S7 |
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| CAS 号 |
145808-47-5 |
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| Sequence |
Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36) |
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| Sequence Shortening |
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36) |
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| 中文名称 |
玛格斑蝎毒素 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Protect from light, stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen) |
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| 参考文献 |
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