Toddaculin(Synonyms: 飞龙掌血素)

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天然产物 天然产物苯丙素类 Phenylpropanoids

Toddaculin (Synonyms: 飞龙掌血素)

Toddaculin 是一种天然香豆素，可诱导白血病细胞分化和凋亡。Toddaculin 抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。Toddaculin 还具有抗炎活性。

Toddaculin(Synonyms: 飞龙掌血素)

Toddaculin Chemical Structure

CAS No. : 4335-12-0

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生物活性

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

体外研究
(In Vitro)

Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1].
Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

274.31

Formula

C16H18O4
CAS 号

4335-12-0
中文名称

飞龙掌血素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46.

    [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158.

    [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.