Khellin(Synonyms: 呋喃并色酮)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Khellin (Synonyms: 呋喃并色酮)

Khellin 是一种呋喃并色酮，能从 Ammi visnuga L. 中提取得到。Khellin 是一种 EGFR 抑制剂，其 IC50 为 0.15 µM。Khelline 在体外具有抗增殖活性。Khellin 具有抗痉挛和冠状动脉舒张作用。

Khellin(Synonyms: 呋喃并色酮)

Khellin Chemical Structure

CAS No. : 82-02-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

IC50 & Target

IC50: 0.15 µM (EGFR)[1]
体外研究
(In Vitro)

Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells[1].
Khellin inhibits the pathways of Ca2+ influx which are activated by both noradrenaline and high K+[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.24

Formula

C14H12O5
CAS 号

82-02-0
中文名称

呋喃并色酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81.

    [2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41.