上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Ilexhainanoside D (Synonyms: 海南冬青苷D)
Ilexhainanoside D 是从 Ilex hainanensis Merr. 中提取的主要三萜皂苷，Ilexhainanoside D 和 Ilexsaponin A1 联合使用后具有抗炎的作用。
Ilexhainanoside D Chemical Structure
CAS No. : 1137648-52-2
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Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect.
The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines.
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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