AdipoGen新产品-新型·独特的生物制品


AdipoGen新产品-新型·独特的生物制品

AdipoGen新产品-新型·独特的生物制品

新型·独特的生物制品

HpARI – 新的人和小鼠IL-33抑制剂

独特的Netrin-1阻断抗体 

增强活性蛋白: hBAFF (60-mer) & hDLL-4 (突变体) 

 

◆IL-33抑制剂/ 2型免疫应答阻断剂 新的


HpARI (Alarmin Release Inhibitor) (rec.) (His)  AG-40B-0178

  HpARI是由小鼠寄生虫多形螺旋线虫分泌的蛋白质。成熟蛋白HpARI通过干扰白细胞介素-33(IL-33)途径抑制2型(过敏)免疫应答。在细胞损伤过程中,HpARI进入坏死细胞核,直接与IL-33和核DNA结合,阻止IL-33分泌及与其受体的结合。

  LIT: M. Osbourne, et al.; Immunity 47, 739 (2017)


AdipoGen新产品-新型·独特的生物制品


IL-33 (oxidation resistant) (human) (rec.) (untagged)  AG-40B-0160
IL-33 (oxidation resistant) (human) (rec.) (His) AG-40B-0167
IL-33 (mouse), mAb (rec.) (blocking) (Bondy-1-1)  AG-27B-0013


◆靶向Netrin-1 / DCC的相互作用


  Netrin-1控制CNS连合轴突和外周运动轴突的导向。还通过与其相关受体结合而起到存活因子的作用,该受体阻止细胞凋亡的开始,并通过调节细胞凋亡参与肿瘤发生。

  LIT: T. Broutier, et al.; EMBO Mol. Med. 8, 96 (2016) | C.P. Prieto, et al.; Stem Cell Res. Ther. 8, 43 (2017)

AdipoGen新产品-新型·独特的生物制品

Netrin-1 (human), mAb (rec.) (H4) (PF) – Neg-Ctrl AG-27B-0020PF
Netrin-1 (human):Fc (human) (rec.) AG-40B-0075
Netrin-1 (human) (rec.)   AG-40B-0040

◆BAFF(60-mer) – 激活全部BAFF受体


  BAFF, Soluble (human) (60-mer) (rec.) (highly active)    AG-40B-0112

  加工过的人BAFF可以保留为三聚体,通常用于TNF家族配体,或者由20个三聚体组装成的60聚体。BAFF(60-mer)的寡聚形式模拟膜结合的BAFF并激活所有BAFF受体(BAFF-R,TACI和BCMA),而BAFF(3-mer)仅触发BAFF-R信号传导。

  LIT: C. Bossen, et al.; Blood 111, 1004 (2008) | C. Bossen, et al.; Eur. J. Immunol. 41, 787 (2011) | J. Nys, et al.; PLoS One 8, e61350 (2013)


AdipoGen新产品-新型·独特的生物制品

BAFF (mouse), mAb (blocking) (Sandy-2)  AG-20B-0063
BAFF-R (mouse), mAb (blocking) (9B9) AG-20B-0034
BAFF, Soluble (human) ELISA Kit (hypersensitive) AG-45B-0001

DLL4突变体 – 一种高活性的Notch配体


DLL4 (human):Fc (human) (rec.) (highly active mutant) AG-40B-0176


  Notch配体δ样蛋白4(DLL4)充当Notch1和Notch4的配体。它由VEGF诱导后作为负反馈调节因子并在血管生成发芽中发挥作用。DLL4还促进巨噬细胞的炎性活化以及Th17和Treg增殖。 高活性突变体DLL4蛋白与人Notch1相互作用, 其亲和力相对于WT DLL4,会增强> 20倍。

 

AdipoGen新产品-新型·独特的生物制品

DLL4 (human):Fc (human) (rec.)  AG-40A-0077Y
DLL1 (human):Fc (human) (rec.) AG-40A-0116Y
Jagged-2 (human):Fc (human) (rec.)  AG-40A-0155Y

◆产品列表


产品列表

产品名称

规格

AG-40B-0160-C010

IL-33 (oxidation resistant)   (human) (rec.) (untagged)
    不带标签的重组人白介素-33(抗氧化)

10 ug

AG-40B-0160-C100

IL-33 (oxidation resistant)   (human) (rec.) (untagged)
    不带标签的重组人白介素-33(抗氧化)

100 ug

AG-40B-0167-C010

IL-33 (oxidation resistant)   (human) (rec.) (His)
    IL-33(抗氧化)(人)(His标签融合)

10 ug

AG-40B-0167-C100

IL-33 (oxidation resistant)   (human) (rec.) (His)
    IL-33(抗氧化)(人)(His标签融合)

100 ug

AG-27B-0013-C100

anti-IL-33 (mouse), mAb (rec.)   (blocking) (Bondy-1-1)
    抗小鼠白介素-33单抗(封闭作用)(Bondy-1-1)

100 ug

AG-27B-0013PF-C100

anti-IL-33 (mouse), mAb (rec.)   (blocking) (Bondy-1-1) (preservative free)
    抗小鼠白介素-33单抗(封闭作用)(Bondy-1-1)(不含防腐剂)

100 ug

AG-27B-0013PF-C500

anti-IL-33 (mouse), mAb (rec.)   (blocking) (Bondy-1-1) (preservative free)
    
    抗小鼠白介素-33单抗(封闭作用)(Bondy-1-1)(不含防腐剂)

500 ug

AG-27B-0013PF-M001

anti-IL-33 (mouse), mAb (rec.)  

 (blocking) (Bondy-1-1) (preservative free)
    抗小鼠白介素-33单抗(封闭作用)

(Bondy-1-1)(不含防腐剂)

1 mg

AG-27B-0020PF-C100

anti-Netrin-1 (human), mAb   (rec.) (H4) (preservative free)

100 ug

AG-27B-0020PF-C500

anti-Netrin-1 (human), mAb   (rec.) (H4) (preservative free)

500 ug

AG-40B-0075-3010

Netrin-1 (human):Fc (human)   (rec.)
    重组型Netrin-1(人):Fc(人)

3×10 ug

AG-40B-0075-C100

Netrin-1 (human):Fc (human)   (rec.)
    重组型Netrin-1(人):Fc(人)

100 ug

AG-40B-0075-C010

Netrin-1 (human):Fc (human)   (rec.)
    重组型Netrin-1(人):Fc(人)

10 ug

AG-40B-0040-C010

Netrin-1 (human) (rec.)
    人Netrin-1重组蛋白

10 ug

AG-40B-0040-3010

Netrin-1 (human) (rec.)
    人Netrin-1重组蛋白套装

3×10 ug

AG-40B-0040-C100

Netrin-1 (human) (rec.)
    人Netrin-1重组蛋白

100 ug

AG-20B-0063-C100

anti-BAFF (mouse), mAb   (blocking) (Sandy-2)
    抗小鼠BAFF单抗(封闭作用) (Sandy-2)

100 ug

AG-20B-0063PF-C100

anti-BAFF (mouse), mAb   (blocking) 

(Sandy-2) (preservative free)
    抗小鼠BAFF单抗(封闭作用)(Sandy-2)(不含防腐剂)

100 ug

AG-20B-0063PF-C500

anti-BAFF (mouse), mAb   (blocking)

 (Sandy-2) (preservative free)
    抗小鼠BAFF单抗(封闭作用)(Sandy-2)(不含防腐剂)

500 ug

AG-20B-0034B-C100

anti-BAFF-R (mouse), mAb (9B9)   (Biotin)
    抗小鼠BAFF-R单抗(9B9)(生物素标记)

100 ug 

AG-20B-0034-C100

anti-BAFF-R (mouse), mAb   (9B9)
    抗小鼠BAFF-R单抗(9B9)

100 ug

AG-20B-0034PF-C100

anti-BAFF-R (mouse), mAb (9B9)   (preservative free)
    抗小鼠BAFF-R单抗(9B9)(不含防腐剂)

100 ug

AG-20B-0034TS-T100

anti-BAFF-R (mouse), mAb (9B9)   (ATTO 647N)
    抗小鼠BAFF-R单抗(9B9)(ATTO 647N)

100 tests

AG-45B-0001-KI01

BAFF, Soluble (human) ELISA Kit   (hypersensitive)
    可溶性BAFF(人) ELISA 试剂盒 (Hypersensitive)

96 wells

AG-40B-0176-C010

DLL4 (human):Fc (human) (rec.)   (highly active mutant)
    δ样蛋白4(人):Fc(人)(高活性突变体)

10 ug

AG-40B-0176-C100

DLL4 (human):Fc (human) (rec.)   (highly active mutant)
    δ样蛋白4(人):Fc(人)(高活性突变体)

100 ug

AG-40A-0077Y-C010

DLL4 (human):Fc (human)   (rec.)
    重组型DLL4(人):Fc(人)

10 ug

AG-40A-0077Y-C050

DLL4 (human):Fc (human)   (rec.)
    重组型DLL4(人):Fc(人)

50 ug 

AG-40A-0116Y-C010

DLL1 (human):Fc (human)   (rec.)
    重组型DLL1 (人):Fc (人)

10 ug

AG-40A-0116Y-C050

DLL1 (human):Fc (human)   (rec.)
    重组型DLL1 (人):Fc (人)

50 ug

AG-40A-0155Y-C010

Jagged-2 (human):Fc (human)   (rec.)
    重组型Jagged-2 (人):Fc (人)

10 ug