LS-BF1

发表于由

LS-BF1;

LS-BF1 是一种稳定、低毒的阳离子抗菌肽。LS-BF1 通过细胞膜破坏机制显示出广谱抗菌活性，包括具有挑战性的ESKAPE病原体。LS-BF1 在小鼠感染模型中显示出良好的体内清除细菌效果。

LS-BF1amp;;

LS-BF1 Chemical Structure

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生物活性

LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

分子量

2084.64

Formula

C107H166N28O15
Sequence Shortening

VKRFKKFFRKFKKFV-NH2 (Lys6-Lys10，(E)-but-2-enyl cross-linked)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hu Y, et al. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022;65(1):579-591.