AC 187 TFA; 纯度: 99.56%
AC 187 TFA 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂,IC50 为 0.48 nM,Ki 为 0.275 nM。AC 187 TFA 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 TFA 具有神经保护作用。
AC 187 TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3000 | In-stock | |
10 mg | ¥4800 | In-stock | |
25 mg | ¥9700 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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生物活性 |
AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects[1][2]. |
IC50 Target |
IC50: 0.48 nM (amylin receptor) |
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体外研究 (In Vitro) |
AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
AC 187 (30 mg/mL) increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia in hyperinsulinemic clamps in Sprague-Dawley (HSD) rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
3004.27 |
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Formula |
C129H206F3N37O42 |
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Sequence |
Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 |
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Sequence Shortening |
Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (33.29 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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