Ac-YVAD-CHO(Synonyms: L-709049)

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Ac-YVAD-CHO;(Synonyms: L-709049)

Ac-YVAD-CHO (L-709049) 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂，小鼠和人类 Ki 值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO 可抑制成熟 IL-lβ 的产生。

Ac-YVAD-CHOamp;;(Synonyms: L-709049)

Ac-YVAD-CHO Chemical Structure

CAS No. : 143313-51-3

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生物活性

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].

IC50 Target

IL-1β

3 nM (Ki)

IL-1β

0.76 nM (Ki)

体外研究
(In Vitro)

Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1].
Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1].
Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 female mice
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: I.p.; 1 hour
Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly.
Animal Model: CD1 female mice
Dosage: 50 mg/kg (Pharmacokinetic Analysis)
Administration: I.p.; 1 hour
Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection.
Animal Model: P. acnes-sensitized mice
Dosage: 30 mg/kg
Administration: I.p.; 6 hours
Result: Suppressed IL-1β levels.

分子量

492.52

Formula

C23H32N4O8
CAS 号

143313-51-3
Sequence Shortening

Ac-YVAD-CHO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.