Allo-aca TFA

Allo-aca TFA;

Allo-aca TFA 是一种瘦素肽模拟物,是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca TFA在多种体外和体内模型中阻断瘦素信号传导和作用。

Allo-aca TFAamp;;

Allo-aca TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Allo-aca TFA 的其他形式现货产品:

Allo-aca

生物活性

Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].

体外研究
(In Vitro)

Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca TFA administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1188.21

Formula

C50H76F3N13O17

Sequence Shortening

{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584.

    [2]. Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13.