β-Amyloid (1-40) (rat)(Synonyms: β淀粉样肽(1-40)(鼠))

发表于由

β-Amyloid (1-40) (rat);(Synonyms: β淀粉样肽(1-40)(鼠))

β-Amyloid (1-40) (rat) 是蛋白水解切割淀粉样蛋白前体蛋白的易聚集产物，可以用于阿尔茨海默病的研究。

β-Amyloid (1-40) (rat)amp;;(Synonyms: β淀粉样肽(1-40)(鼠))

β-Amyloid (1-40) (rat) Chemical Structure

CAS No. : 144409-98-3

规格 价格 是否有货
1 mg ￥2200 询问价格 货期

* Please select Quantity before adding items.

生物活性

β-Amyloid (1-40) (rat) is the prone-to-aggregation product of amyloid precursor protein proteolytic cleavage, and can be used for the research of Alzheimer’s disease[1].

分子量

4233.76

Formula

C190H291N51O57S
CAS 号

144409-98-3
Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
Sequence Shortening

DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
中文名称

β淀粉样肽(1-40)(鼠)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Shi X, et al. Rat hippocampal proteomic alterations following intrahippocampal injection of amyloid betapeptide (1-40). Neurosci Lett. 2011 Aug 15;500(2):87-91.
Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Shi X, et al. Rat hippocampal proteomic alterations following intrahippocampal injection of amyloid betapeptide (1-40). Neurosci Lett. 2011 Aug 15;500(2):87-91.