C3a (70-77) (TFA)(Synonyms: Complement 3a (70-77) (TFA))

发表于由

C3a (70-77) (TFA);(Synonyms: Complement 3a (70-77) (TFA)) 纯度: 95.02%

C3a (70-77) TFA (Complement 3a (70-77) TFA) 是对应于 C3a 的 COOH 末端的八肽，表现出 C3a 的特异性和 1 至 2％ 的生物活性。

C3a (70-77) (TFA)amp;;(Synonyms: Complement 3a (70-77) (TFA))

C3a (70-77) (TFA) Chemical Structure

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥1900 In-stock
10 mg ￥3200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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C3a (70-77) (TFA) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a[1][2].

体外研究
(In Vitro)

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

937.96

Formula

C37H62F3N13O12
Sequence

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg
Sequence Shortening

ASHLGLAR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (106.61 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0661 mL 5.3307 mL 10.6614 mL
5 mM 0.2132 mL 1.0661 mL 2.1323 mL
10 mM 0.1066 mL 0.5331 mL 1.0661 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.

    [2]. Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63.