Apelin-36(rat, mouse) TFA

发表于由

Apelin-36(rat, mouse) TFA;

Apelin-36(rat, mouse) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-36(rat, mouse) TFA 与 APJ 受体结合，IC50 为 5.4 nM，显著抑制 cAMP 的产生，EC50 为 0.52 nM。Apelin-36(rat, mouse) TFA 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-36(rat, mouse) TFAamp;;

Apelin-36(rat, mouse) TFA Chemical Structure

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生物活性

Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) TFA blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ[1][2].

IC50 Target[1]

HIV-1

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HIV-2

;

分子量

4314.91

Formula

C187H305F3N68O45S
Sequence

Leu-Val-Lys-Pro-Arg-Thr-Ser-Arg-Thr-Gly-Pro-Gly-Ala-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

LVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawamata Y, et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta. 2001;1538(2-3):162-171.

    [2]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.