标签归档：询价

Hythiemoside B

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Hythiemoside B;

Hythiemoside B 以白色无定形粉末的形式被分离。Hythiemoside B 是一种从 Siegesbecikia orientalis L. (Asteraceae) 地上部分分离得到的 ent-pimarane glucoside。

Hythiemoside B

Hythiemoside B Chemical Structure

CAS No. : 853267-90-0

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生物活性

Hythiemoside B is isolated as a white amorphous powder. Hythiemoside B is an ent-pimarane glucoside isolated from the aerial part of Siegesbecikia orientalis L. (Asteraceae)[1].

分子量

526.66

Formula

C28H46O9
CAS 号

853267-90-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Giang PM, et al. ent-pimarane-type diterpenoids from Siegesbeckia orientalis L. Chem Pharm Bull (Tokyo). 2005;53(2):232-234.

Gentianose

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Gentianose;

Gentianose 是多年生黄龙胆贮藏根中主要的碳水化合储备物。

Gentianose

Gentianose Chemical Structure

CAS No. : 25954-44-3

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生物活性

Gentianose is a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea[1].

分子量

504.44

Formula

C18H32O16
CAS 号

25954-44-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Imperio D, et al. Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds. Food Chem. 2021;344:128588.

Eupteleasaponin I

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Eupteleasaponin I;

Eupteleasaponin I 是多花领春木中的成分，可能具有胃保护功能。

Eupteleasaponin I

Eupteleasaponin I Chemical Structure

CAS No. : 290809-29-9

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生物活性

Eupteleasaponin I is a component of Euptelea polyandra, may has gastroprotective activity[1].

分子量

1043.19

Formula

C52H82O21
CAS 号

290809-29-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yoshikawa M, et al. Bioactive saponins and glycosides. XVI. Nortriterpene oligoglycosides with gastroprotective activity from the fresh leaves of Euptelea polyandra Sieb. et Zucc. (1): structures of Eupteleasaponins I, II, III, IV, V, and V acetate. Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1045-50.

Neonuezhenide

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Neonuezhenide;

Neonuezhenide 对自由基诱导的红血球溶血有较强的抗氧化作用。

Neonuezhenide

Neonuezhenide Chemical Structure

CAS No. : 96382-91-1

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生物活性

Neonuezhenide exhibits strong antioxidant effect against hemolysis of red blood cells induced by free radicals[1].

分子量

702.65

Formula

C31H42O18
CAS 号

96382-91-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He ZD, et al. Antioxidative glucosides from the fruits of Ligustrum lucidum. Chem Pharm Bull (Tokyo). 2001;49(6):780-784.

Complanatoside B

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Complanatoside B;

Complanatoside B 是一种具有抗炎作用的黄酮类化合物。

Complanatoside B

Complanatoside B Chemical Structure

CAS No. : 142473-99-2

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生物活性

Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects[1].

分子量

756.66

Formula

C33H40O20
CAS 号

142473-99-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hua Fan, et al. Phyllolobium chinense Fisch Flavonoids (PCFF) Suppresses the M1 Polarization of LPS-Stimulated RAW264.7 Macrophages by Inhibiting NF-κB/iNOS Signaling Pathway. Front Pharmacol. 2020 Jun 18;11:864.

LXW7

发表于由

LXW7;

LXW7 是一种含 Arg-Gly-Asp (RGD) 的环状肽，是一种整合素 αvβ3 抑制剂，对 αvβ3 整联蛋白具有很高的结合亲和力，IC50 为 0.68 μM。LXW7 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。

LXW7amp;;

LXW7 Chemical Structure

CAS No. : 1313004-77-1

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LXW7 的其他形式现货产品:

LXW7 TFA

生物活性

LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect[1][2][3].

IC50 Target

IC50: 0.68 μM (αvβ3 integrin)[1]
体外研究
(In Vitro)

LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery[1].
LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-280 g) subjected to middle cerebral artery occlusion (MCAO)[3]
Dosage: 100 μg/kg
Administration: Intravenous injection
Result: Infarct volumes and BWC were significantly lower compared to those in the MCAO+PBS (control) group.

分子量

820.89

Formula

C29H48N12O12S2
CAS 号

1313004-77-1
Sequence Shortening

CGRGDDVC-NH2 (Disulfide bridge:Cys1-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23.

    [2]. Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.

    [3]. Fang T, et al. LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5287.

1,4-D-Gulonolactone

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

1,4-D-Gulonolactone;

1,4-D-Gulonolactone 是一种内源性代谢产物。

1,4-D-Gulonolactone

1,4-D-Gulonolactone Chemical Structure

CAS No. : 6322-07-2

规格 价格 是否有货 数量
1 g ￥350 In-stock
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1,4-D-Gulonolactone 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Lipid Compound Library

生物活性

1,4-D-Gulonolactone is an endogenous metabolite.

分子量

178.14

Formula

C6H10O6
CAS 号

6322-07-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 250 mg/mL (1403.39 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

Cerebroside C

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Cerebroside C;

Cerebroside C 是一种鞘脂，是一种真菌代谢物。Cerebroside C 在水稻中可引起防御反应。

Cerebroside C

Cerebroside C Chemical Structure

CAS No. : 98677-33-9

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生物活性

Cerebroside C, a sphingolipid, is a fungal metabolite. Cerebroside C licits defense responses in rice[1].

IC50 Target

Microbial Metabolite

;

分子量

754.09

Formula

C43H79NO9
CAS 号

98677-33-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kenji Umemura,et al.Cerebroside elicitor confers resistance to fusarium disease in various plant specie. Phytopathology. 2004 Aug;94(8):813-8.

Clematichinenoside C

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Clematichinenoside C;

Clematichinenoside C 是存在于裂叶铁线莲中的一种三萜皂苷.

Clematichinenoside C

Clematichinenoside C Chemical Structure

CAS No. : 177912-24-2

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生物活性

Clematichinenoside C is one of triterpenoid saponins found in Clematis parviloba[1].

分子量

1499.63

Formula

C70H114O34
CAS 号

177912-24-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yan LH, Xu LZ, Lin J, Yang SL, Feng YL. Triterpenoid saponins from the stems of Clematis parviloba. J Asian Nat Prod Res. 2009;11(4):332-338.

Eclalbasaponin I

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Eclalbasaponin I;

Eclalbasaponin I 从 Eclipta prostrata L. (Asteraceae) 分离，具有抗肿瘤活性。 Eclalbasaponin I 抑制肝癌细胞 smmc-7721 的增殖，其 IC50 值为 111.1703 μg/ml。

Eclalbasaponin I

Eclalbasaponin I Chemical Structure

CAS No. : 158511-59-2

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生物活性

Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC50 value of 111.1703 μg/ml[1].

IC50 Target

IC50: 111.1703 μg/ml (smmc-7721 cells)
分子量

796.98

Formula

C42H68O14
CAS 号

158511-59-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu QM, et al. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. Food Chem Toxicol. 2012 Nov;50(11):4016-22.