标签归档：esculin

Esculin(Synonyms: 秦皮甲素)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Esculin;(Synonyms: 秦皮甲素) 纯度: 99.97%

Esculin 是一种荧光香豆素葡萄糖苷，是灰树皮的有效成分。Esculin 通过 MAPK 信号通路改善实验性糖尿病肾病 (DN) 的认知障碍，并发挥抗氧化应激和抗炎作用。

Esculin(Synonyms: 秦皮甲素)

Esculin Chemical Structure

CAS No. : 531-75-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
500 mg ￥500 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

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Esculin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • MAPK Compound Library
  • Natural Product Library
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生物活性

Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway[2].

IC50 Target[2]

p38 MAPK

;

分子量

340.28

Formula

C15H16O9
CAS 号

531-75-9
中文名称

秦皮甲素；七叶灵；七叶苷；七叶甙；马粟树皮苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (293.88 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9388 mL 14.6938 mL 29.3876 mL
5 mM 0.5878 mL 2.9388 mL 5.8775 mL
10 mM 0.2939 mL 1.4694 mL 2.9388 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807.

    [2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.