Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent^[1]. Proflavine hemisulfate behaves as a pore blocker for K_ir3.2. Proflavine hemisulfate is a potential lead compound for K_ir3.2-associated neurological diseases^[2].

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of K_ir3.2-transformant cells and K_ir3.2 activity in a concentration-dependent manner^[1].
Proflavine (300 μM) progressively reduces the current amplitude of K_ir3.2 mutant to 27.7±4.3% of the control^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

258.29

C₁₃H₁₂N₃O₂S_0.5

1811-28-5

硫酸原黄素

Room temperature in continental US; may vary elsewhere.

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

H₂O : ≥ 5 mg/mL (19.36 mM)

* “≥” means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

  [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.

  [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.