标签归档：proflavine

Proflavine hemisulfate(Synonyms: Proflavin hemisulfate 3,6-Diaminoacridine hemisulfate)

发表于由

Proflavine hemisulfate;(Synonyms: Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate) 纯度: 98.17%

Proflavine hemisulfate 是一种吖啶染料，也是一种 DNA嵌入剂。可用作抗菌剂 (Anti-microbial)。Proflavine hemisulfate 可作为 Kir3.2 孔阻滞剂。Proflavine hemisulfate 可用于研究与 Kir3.2 相关的神经系统疾病。

Proflavine hemisulfateamp;;(Synonyms: Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

Proflavine hemisulfate Chemical Structure

CAS No. : 1811-28-5

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥550 In-stock
100 mg ￥500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].

体外研究
(In Vitro)

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner[1].
Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Kir3.2*-transformant BYT123 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Dose-dependent inhibition of the growth of Kir3.2*-transformant cells.
Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.

体内研究
(In Vivo)

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (weighing approximately 200 g)[3]
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result: Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.

Clinical Trial

分子量

258.29

Formula

C13H12N3O2S0.5
CAS 号

1811-28-5
中文名称

硫酸原黄素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 5 mg/mL (19.36 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8716 mL 19.3581 mL 38.7162 mL
5 mM 0.7743 mL 3.8716 mL 7.7432 mL
10 mM 0.3872 mL 1.9358 mL 3.8716 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

    [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.

    [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.