标签归档：synonyms

Damulin B(Synonyms: 达木林B)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Damulin B;(Synonyms: 达木林B)

Damulin B 是一种皂苷类化合物，可存在于绞股蓝中。Damulin B 能诱导细胞凋亡 (apoptosis)，并在体外具有的抗癌活性。

Damulin B(Synonyms: 达木林B)

Damulin B Chemical Structure

CAS No. : 1202868-75-4

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生物活性

Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum.Damulin B can induce cell apoptosis and has anti-cancer activities in vitro[1][2].

分子量

783.00

Formula

C42H70O13
CAS 号

1202868-75-4
中文名称

达木林B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shao-Fang Xing, et al. Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells. Planta Med. 2019 Mar;85(5):394-405.

    [2]. Phi Hung Nguyen, et al. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. . 2011 Nov 1;19(21):6254-60.

Tyroserleutide(Synonyms: 酪丝亮肽)

发表于由

Tyroserleutide;(Synonyms: 酪丝亮肽)

Tyroserleutide (YSL)，可从猪脾脏的降解产物中分离得到，是一种小分子三肽，在体内外均可抑制肿瘤生长。

Tyroserleutideamp;;(Synonyms: 酪丝亮肽)

Tyroserleutide Chemical Structure

CAS No. : 138168-48-6

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Tyroserleutide 的其他形式现货产品:

Tyroserleutide hydrochloride

生物活性

Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].

IC50 Target

Antitumor tripeptide[1][2]
体外研究
(In Vitro)

Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1].
Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2].
Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2].
Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1]
Dosage: 10, 20, 40, and 80 μg/kg
Administration: Injection (i.p.) one time every day until mice were dead.
Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively.

Clinical Trial

分子量

381.42

Formula

C18H27N3O6
CAS 号

138168-48-6
中文名称

酪丝亮肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95.

    [2]. Liang P, et al. pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy. Adv Healthc Mater. 2019 Aug;8(15):e1900306.

1,1,1,1-Kestohexaose(Synonyms: 蔗果六糖)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

1,1,1,1-Kestohexaose;(Synonyms: 蔗果六糖) 纯度: ge;98.0%

1,1,1,1-Kestohexaose 是从Poa ampla 中分离得到的一种寡聚果糖。

1,1,1,1-Kestohexaose(Synonyms: 蔗果六糖)

1,1,1,1-Kestohexaose Chemical Structure

CAS No. : 62512-19-0

规格 价格 是否有货 数量
5 mg ￥2200 In-stock
10 mg ￥3800 In-stock
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1,1,1,1-Kestohexaose 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library

生物活性

1,1,1,1-Kestohexaose is a fructan oligomer isolated from Poa ampla[1].

分子量

990.86

Formula

C36H62O31
CAS 号

62512-19-0
中文名称

蔗果六糖
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

H2O : 250 mg/mL (252.31 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0092 mL 5.0461 mL 10.0922 mL
5 mM 0.2018 mL 1.0092 mL 2.0184 mL
10 mM 0.1009 mL 0.5046 mL 1.0092 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. CHATTERTON, N., HARRISON, P. (1997). Fructan oligomers in Poa ampla. New Phytologist, 136(1), 3-10.

Solasurine(Synonyms: 澳茄新碱)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Solasurine;(Synonyms: 澳茄新碱)

Solasurine 是一种可以从 Solanum surrattence 中分离得到的甾体生物碱。Solasurine 能与 C3-样蛋白酶 (SARS-CoV-2 主蛋白酶) 的氨基酸 Phe8、Pro9、Ile152、Tyr154、Pro293、Phe294、Val297、Arg298 相互作用。

Solasurine(Synonyms: 澳茄新碱)

Solasurine Chemical Structure

CAS No. : 27028-76-8

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生物活性

Solasurine is a steroidal alkaloid that can be isolated from Solanum surrattence. Solasurine can interact with the C3-like protease (SARS-CoV-2 main protease) amino acids Phe8, Pro9, Ile152, Tyr154, Pro293, Phe294, Val297, and Arg298[1].

分子量

721.92

Formula

C39H63NO11
CAS 号

27028-76-8
中文名称

澳茄新碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anamul Hasan, et al. Phytochemicals from Solanum surattense Burm.f. have high binding affinities for C-3 like main protease of COVID-19 (SARS-CoV-2).

Erigeroside(Synonyms: 飞蓬苷)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Erigeroside;(Synonyms: 飞蓬苷)

Erigeroside 是从 Satureja khuzistanica Jamzad 提取的-葡萄糖的衍生物。Erigeroside 具有良好的抗氧化和清除氧化自由基的能力。

Erigeroside(Synonyms: 飞蓬苷)

Erigeroside Chemical Structure

CAS No. : 59219-76-0

规格 价格 是否有货
1 mg ￥5140 询问价格 货期
5 mg ￥15430 询问价格 货期

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生物活性

Erigeroside is as a derivatives of -glucose extracted from Satureja khuzistanica Jamzad. Erigeroside has good ability of anti-oxidation and scavenging oxidation free radical[1].

分子量

274.22

Formula

C11H14O8
CAS 号

59219-76-0
中文名称

飞蓬苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tafazzoli M, et al. Dynamic stereochemistry of erigeroside by measurement of 1H-1H and 13C-1H coupling constants. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Jul;70(2):350-7.

Ophiopogonside A(Synonyms: 川麦冬苷A)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Ophiopogonside A;(Synonyms: 川麦冬苷A)

Ophiopogonside A 是可从ophiopogon japonicas 分离得到的天然产物，具有抗肿瘤活性。

Ophiopogonside A(Synonyms: 川麦冬苷A)

Ophiopogonside A Chemical Structure

CAS No. : 2423917-90-0

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生物活性

Ophiopogonside A, a natural conpound that could be isolated from ophiopogon japonicas, possesses anti-cancer activity[1].

分子量

516.62

Formula

C26H44O10
CAS 号

2423917-90-0
中文名称

川麦冬苷A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zheng, Haoyuan, et al. Compound extracted from ophiopogon japonicus, method thereof and application of compound in preparing drug for inhibiting tumor cell growth. CN111040002A.

Camelliaside B(Synonyms: 山茶苷 B)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Camelliaside B;(Synonyms: 山茶苷 B)

Camelliaside B 是来自茶 (Camellia oleifera) 种子残渣甲醇提取物中的一种类黄酮。

Camelliaside B(Synonyms: 山茶苷 B)

Camelliaside B Chemical Structure

CAS No. : 131573-90-5

规格 价格 是否有货
5 mg ￥3360 询问价格 货期
10 mg ￥5710 询问价格 货期

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生物活性

Camelliaside B is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace[1].

分子量

726.63

Formula

C32H38O19
CAS 号

131573-90-5
中文名称

山茶苷 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kuo PC, et al. Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. J Agric Food Chem. 2010 Aug 11;58(15):8618-22.

Balixafortide(Synonyms: POL6326)

发表于由

Balixafortide;(Synonyms: POL6326)

Balixafortide (POL6326) 是一种有效的，选择性的，耐受性好的肽类 CXCR4 拮抗剂，其 IC50 小于 10 nM。Balixafortide 对 CXCR4 的选择性比包括 CXCR7 在内的许多受体高出 1000 倍。Balixafortide 以 IC50 < 10 nM 阻断 β-arrestin 募集和钙通量。Balixafortide 还是一种有效的造血干细胞和祖细胞 (HSPC) 动员剂，并具有抗癌作用。

Balixafortideamp;;(Synonyms: POL6326)

Balixafortide Chemical Structure

CAS No. : 1051366-32-5

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Balixafortide 的其他形式现货产品:

Balixafortide TFA

生物活性

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2].

IC50 Target[1]

CXCR4

lt;10 nM (IC50)

体外研究
(In Vitro)

Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC50< 200 nM) and Jurkat (IC50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC50 < 20 nM), Namalwa and Jurkat cells (IC50 < 10 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1864.14

Formula

C84H118N24O21S2
CAS 号

1051366-32-5
Sequence

Cyclo(Ala-Cys-Ser-Ala-Pro-{Dab}-Arg-Tyr-Cys-Tyr-Gln-Lys-Pro-Pro-Tyr-His) (Disulfide bridge: Cys2-Cys9)
Sequence Shortening

Cyclo(ACSAP-{Dab}-RYCYQKPPYH) (Disulfide bridge: Cys2-Cys9)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zimmermann J, et al. Anti-tumor cell activity and in vitro profile of the next generation CXCR4 antagonist Balixafortide. Ann Oncol. 2018 Oct;29 Suppl 8:viii103.

    [2]. Karpova D, et al. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial. J Transl Med. 2017 Jan 3;15(1):2.

Brandioside(Synonyms: 2′-Acetylpoliumoside; 2′-O-Acetylpoliumoside)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Brandioside;(Synonyms: 2′-Acetylpoliumoside; 2′-O-Acetylpoliumoside)

Brandioside 是可从 Brandisia hancei 天然苯丙素类糖苷。

Brandioside(Synonyms: 2

Brandioside Chemical Structure

CAS No. : 133393-81-4

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生物活性

Brandioside is a natural phenylpropanoid glycoside from Brandisia hancei[1].

分子量

812.77

Formula

C37H48O20
CAS 号

133393-81-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Z D He, et al. Brandioside, a phenylpropanoid glycoside from Brandisia hancei. Phytochemistry. 1991;30(2):701-2.

Cauloside F(Synonyms: 红毛七皂苷 F)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Cauloside F;(Synonyms: 红毛七皂苷 F)

Cauloside F 是从铁线莲中分离的到的三萜皂苷类化合物。

Cauloside F(Synonyms: 红毛七皂苷 F)

Cauloside F Chemical Structure

CAS No. : 60451-47-0

规格 价格 是否有货
5 mg ￥2690 询问价格 货期
10 mg ￥4570 询问价格 货期

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生物活性

Cauloside F is a triterpenoid saponin isolated from Clematis akebioides.

分子量

1237.38

Formula

C59H96O27
CAS 号

60451-47-0
中文名称

红毛七皂苷 F
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ya-Mei Zhang, et al. Chemical constituents isolated from Clematis akebioides (Maximowicz) Veitch. Biochemical Systematics and Ecology (2019), 83, 13-16.