加拿大Silicycle硅胶填料SiliaBond Amine (WAX) (R52030B)

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SiliaBond Amine (WAX) (R52030B)

SiliaBond Amine (WAX) (R52030B)

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Product Number Quantity  
R52030B-10G 10 g

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R52030B-25G 25 g

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R52030B-50G 50 g

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R52030B-100G 100 g

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R52030B-250G 250 g

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R52030B-500G 500 g

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R52030B-1KG 1 kg

SiliaBond Amine (WAX) (R52030B)   Loading…  

Details

SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Researchers compared PS-Triamine to SiliaBond Amine for the removal of acid chlorides in the synthesis of 2,9-disubstituted guaninies. Using SiliaBond Amine to remove excess acid chloride gave higher yields and better purity in more than 93% compared to PS-Trisamine. For complete details, please refer to the scavenger case study.1

SiliaBond Amine eliminates tedious post reaction purification. It scavenges faster, is easier to add and filter, and can be used in any solvent. Si-NH2 has been shown to be effective metal scavenger2 and catalyst for Knoevenagel reactions.3, 4  It has also been used as support in solid-phase chemistry for peptide synthesis followed by enzymatic hydrolysis5 and for Claisen rearrangement.6

Metals Removed

  • Best scavenger for: Cd, Cr, Pd & Rh.
  • Good scavenger for: Co, Cu, Fe, Hg, Pb, W & Zn.

SiliaBond Amine is also used in chromatography as normal phase sorbent. It is used in the preparation of peptides, drugs and metabolites from physiological fluids and for the separation of mono- and polysaccharides.  Si-NH2 is more retentive towards basic compounds. When used at pH ≤ 7.8, it is protonated and may be used as a weak anion exchanger (WAX). SiliaBond Amine has been used for the solid-phase extraction of sugars,7 for the separation of steroids,8 cholesterol, and triglycerides,9 and in size exclusion chromatography of cationic polymers.10  Si-NH2 is also available non-endcapped (R52130B) for additional retention of polar and cationic compounds.

APPLICATION NOTES
Click here to see the application notes about SiliaBond®

POSTERS
Click here to see all the documentation about SiliaBond®

RELATED PUBLICATIONS

  1. Tet. Lett., 41 (2000) 3573
  2. Chem. Commun., (2000) 1145
  3. Tet. Lett., 29 (1988) 2261
  4. J. Chem. Soc. Perk. Trans. I, (1989) 105
  5. Tet. Lett., 44 (2003) 6083
  6. Molecular Diversity, 3 (1998) 161
  7. J. Liq. Chromato., 14 (1991) 1185
  8. J. Chromato. A, 392 (1987) 464
  9. J. Chromato. B, 434 (1988) 395
  10. J. Chromato. A, 389 (1987) 103

Documentations

PRODUCT SPECIFICATIONS

MSDS-R51030B

Additional Information

Particle Shape Irregular
Array Amine (WAX)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry and cool (<8°C)
Solvent Compatibility All solvents, aqueous and organic
Typical Density 700 g/L
Molecular Loading 1.20 mmol/g
Color Orange
Cadmium (Cd) Preferred Scavengers
Chromium (Cr) Preferred Scavengers
Cobalt (Co) Scavenge
Copper (Cu) Scavenge
Iron (Fe) Scavenge
Mercury (Hg) Scavenge
Lead (Pb) Scavenge
Palladium (Pd-2+) Scavenge
Platinum (Pt) Preferred Scavengers
Rhodium (Rh-1+) Preferred Scavengers
Rhodium (Rh-2+) Preferred Scavengers
Tungsten (W) Scavenge
Zinc (Zn) Scavenge

加拿大Silicycle硅胶填料SiliaBond Carbamate (CAR) (R50130B)

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SiliaBond Carbamate (CAR) (R50130B)

SiliaBond Carbamate (CAR) (R50130B)

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Product Number Quantity  
R50130B-10G 10 g

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R50130B-25G 25 g

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R50130B-50G 50 g

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R50130B-100G 100 g

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R50130B-250g 250 g

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R50130B-500G 500 g

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R50130B-1KG 1 kg

SiliaBond Carbamate (CAR) (R50130B)   Loading…  

Details

SiliaBond® Carbamate (CAR) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alcohols, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.

Si-CAR has been used to scavenge amines in a “cap-tag” methodology for oligosaccharide preparation by automated solid phase synthesis1 and in the preparation of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.2

Silica supported Carbamate has superior reactivity in a broader range of solvents when compared to polymer-based materials.

RELATED PUBLICATIONS

  1. Angew. Chem. Int. Ed., 40 (2001) 4433
  2. Org. Lett., 4 (2002) 1167

Additional Information

Particle Shape Irregular
Array Carbamate
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry and cool (<8°C)

加拿大Silicycle硅胶填料SiliaBond Carbodiimide (DCC) (R70530B)

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SiliaBond Carbodiimide (DCC) (R70530B)

SiliaBond Carbodiimide (DCC) (R70530B)

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Product Number Quantity  
R70530B-10G 10 g

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R70530B-25G 25 g

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R70530B-50G 50 g

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R70530B-100G 100 g

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R70530B-250G 250 g

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R70530B-500G 500 g

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R70530B-1KG 1 kg

SiliaBond Carbodiimide (DCC) (R70530B)   Loading…  

Details

SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters. Loading is determined by titration of the excess oxalic acid after formation of oxalic anhydride. The use of silica-supported DCC eliminates purification issues caused by the formation of DCU as it remains bound to the silica.

 

Applications and uses of SiliaBond Carbodiimide are not restricted to standard amides. As a matter of fact, it has been successfully used for the synthesis of Weinreb amides and acylsulfonamides.

PRODUCT SPECIFICATIONS

MSDS-R70530B

APPLICATION NOTES
Amide Coupling : Click here
Amide & Ester Synthesis : Click here

POSTERS
Click here to see all the documentation about SiliaBond®

RELATED PUBLICATIONS

  1. Tet. Lett., 50 (2009) 2762
  2. Tet. Lett., 50 (2009) 2552
  3. PNAS., 108 (2011) 6751

Additional Information

Particle Shape Irregular
Array Carbodiimide (DCC)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Storage Condition Keep dry, cool (<8°C) and under Argon

加拿大Silicycle硅胶填料SiliaBond Carbonate (CO3) (R66030B)

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SiliaBond Carbonate (CO3) (R66030B)

SiliaBond Carbonate (CO3) (R66030B)

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Product Number Quantity  
R66030B-10G 10 g

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R66030B-25G 25 g

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R66030B-50G 50 g

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R66030B-100G 100 g

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R66030B-250G 250 g

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R66030B-500G 500 g

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R66030B-1KG 1 kg

SiliaBond   Loading…  

Details

SiliaBond® Carbonate (SiCO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

SiliaBond Carbonate is also very efficient at scavenging boronic acids: 99% removal of phenylboronic acid with one equivalent in DCM at room temperature after 1h. Si-CO3 can free base ephedrine hydrochloride quantitatively (100% yield determined by 1H NMR) using 4 equivalents at room temperature for two hours.

PRODUCT SPECIFICATIONS

MSDS-R66030B

APPLICATION NOTES
Scavenging Using SiliaBond Carbonate

RELATED PUBLICATIONS

  1. Org. Lett., 4 (2002) 1167
  2. Org. Lett., 5 (2003) 4721
  3. J. Comb. Chem., 9 (2007) 677
  4. J. Comb. Chem., 10 (2008) 235
  5. Bioorg. Med. Chem. Lett., 20 (2010), 232

Additional Information

Particle Shape Irregular
Array Carbonate (CO3)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry

加拿大Silicycle硅胶填料SiliaBond Cyanoborohydride (CBH) (R66730B)

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SiliaBond Cyanoborohydride (CBH) (R66730B)

SiliaBond Cyanoborohydride (CBH) (R66730B)

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Product Number Quantity  
R66730B-10G 10 g

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R66730B-25G 25 g

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R66730B-50G 50 g

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R66730B-100G 100 g

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R66730B-250G 250 g

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R66730B-500G 500 g

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R66730B-1KG 1 kg

SiliaBond Cyanoborohydride (CBH) (R66730B)   Loading…  

Details

SiliaBond® Cyanoborohydride (SiCBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. Cyanide contamination of the product is a concern when using the solution phase equivalent. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica. Additionally, it may be used to reduce α, β-unsaturated carbonyl to the corresponding unsaturated alcohol.

To see if any cyanide ion was leaching from the silica, 1 g of SiliaBond Cyanoborohydride has been washed in 10 mL of methanol for 24 hours. Cyanide strips indicated less than 3 ppm in each test performed.

PRODUCT SPECIFICATIONS

MSDS-R66730B

APPLICATION NOTE
Reductive animation : Click here

POSTER
Click here to see all the documentation about SiliaBond®

RELATED PUBLICATION

  1. Tet. Lett., 50 (2009) 6658
  2. Tet. Lett., 50 (2009) 2552

Additional Information

Particle Shape Irregular
Array Cyanoborohydride (CBH)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Storage Condition Keep dry, cool (<8°C) and under Argon

加拿大Silicycle硅胶填料SiliaBond Dimethylamine (DMA) (R45030B)

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaBond Dimethylamine (DMA) (R45030B)

SiliaBond Dimethylamine (DMA) (R45030B)

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Product Number Quantity  
R45030B-10G 10 g

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R45030B-25G 25 g

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R45030B-50G 50 g

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R45030B-100G 100 g

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R45030B-250G 250 g

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R45030B-500G 500 g

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R45030B-1KG 1 kg

SiliaBond Dimethylamine (DMA) (R45030B)   Loading…  

Details

SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael1or Knoevenagel2 reactions. It can also be used as a catalyst for alkane oxidation.3 Unlike polystyrene based resins, the amine is not a benzyl amine and therefore is not susceptible to cleavage by electrophiles.

PRODUCT SPECIFICATIONS

MSDS-R45030B

RELATED PUBLICATIONS

  1. Synlett (1998) 625
  2. J. Chem. Soc. Perkin Trans. 1, (1989) 105
  3. J. Org. Chem., 56 (1991) 1981


Additional Information

Particle Shape Irregular
Array Diethylamine (DMA)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry and cool (<8°C)

加拿大Silicycle硅胶填料SiliaBond Diol nec (R35030B)

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaBond Diol nec (R35030B)

SiliaBond Diol nec (R35030B)

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Product Number Quantity  
R35030B-10G 10 g

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R35030B-25G 25 g

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R35030B-50G 50 g

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R35030B-100G 100 g

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R35030B-250G 250 g

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R35030B-500G 500 g

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R35030B-1KG 1 kg

SiliaBond Diol nec (R35030B)   Loading…  

Details

SiliaBond® Diol (Si-Diol) may be used as boronic acid scavenger in the same way as PS-DEAM.

SiliaBond Diol may also be used as polar sorbent in normal phase and aqueous size exclustion chromatography. Like bare silica, SiliaBond Diol has the ability to form hydrogen bonds and the capacity to separate structural isomers. Since most of its surface is covered with organic functions, the SiliaBond Diol absorbs less water, which leads to a more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water. It has a different selectivity than bare silica gel and slight modifications in the composition of the solvent mixture may be necessary to obtain similar retention. In SPE, it is used for the isolation of drugs and metabolites from physiological fluids.

PRODUCT SPECIFICATIONS

MSDS-R35030B

RELATED PUBLICATION

  1. Org. Lett., 6 (2004) 2317

Additional Information

Particle Shape Irregular
Array Diol
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Non-endcapped
Storage Condition Keep dry

加拿大Silicycle硅胶填料SiliaBond DMAP (R75630B)

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaBond DMAP (R75630B)

SiliaBond DMAP (R75630B)

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Product Number Quantity  
R75630B-10G 10 g

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R75630B-25G 25 g

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R75630B-50G 50 g

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R75630B-100G 100 g

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R75630B-250G 250 g

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R75630B-500G 500 g

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R75630B-1KG 1 kg

SiliaBond DMAP (R75630B)   Loading…  

Details

SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation. These reactions are well known in organic synthesis and are very useful in various domains. SiliaBond DMAP presents the advantage over its free counterpart as it can be removed by a simple filtration. One of the most important applications for this product is the “Catch and Release” for amide synthesis.

SiliaBond DMAP can also be used in other types of reactions like esterification of alcohols and nucleophilic rearrangements.

PRODUCT SPECIFICATIONS

MSDS-R75630B

APPLICATION NOTE
Click here to see the application notes about SiliaBond®

Additional Information

Particle Shape Irregular
Array DMAP
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry, cool (<8°C) and under Argon

加拿大Silicycle硅胶填料SiliaBond Guanidine (GUA) (R68230B)

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaBond Guanidine (GUA) (R68230B)

SiliaBond Guanidine (GUA) (R68230B)

Prices do not include applicable taxes, customs, duties and/or shipping.

Product Number Quantity  
R68230B-10G 10 g

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R68230B-25G 25 g

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R68230B-50G 50 g

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R68230B-100G 100 g

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R68230B-250G 250 g

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R68230B-500G 500 g

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R68230B-1KG 1 kg

SiliaBond Guanidine (GUA) (R68230B)   Loading…  

Details

SiliaBond®  Guanidine is a silica-supported diisopropylguanidine ligand.

It is a very powerful scavenger for the chelating of organic acids in general, especially boronic acids
and phenolic acids.

It may also be used as a very strong base. It is sufficiently basic to deprotonate moderately acidic hydrogens,
as in the alkylation of amines and phenols (Williamson ether synthesis) and the esterification of carboxylic acids using alkyl halides.

It is also a new product that replaces SiliaBond TBD.

Documentations

SPECIFICATION SHEET

Download the Specification Sheet

APPLICATION NOTE

Application Note for SiliaBond Guanidine

Additional Information

Particle Shape Irregular
Array Guanidine
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry under Argon
Solvent Compatibility All solvents, aqueous and organic
Typical Density 732 g/L
Molecular Loading 0.80 mmol/g
Color Light Yellow

加拿大Silicycle硅胶填料SiliaBond Pentafluorophenyl (PFP) (R67530B)

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaBond Pentafluorophenyl (PFP) (R67530B)

SiliaBond Pentafluorophenyl (PFP) (R67530B)

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Product Number Quantity  
R67530B-10G 10 g

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R67530B-25G 25 g

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R67530B-50G 50 g

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R67530B-100G 100 g

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R67530B-250G 250 g

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R67530B-500G 500 g

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R67530B-1KG 1 kg

SiliaBond Pentafluorophenyl (PFP) (R67530B)   Loading…  

Details

SiliaBond® Pentafluorophenyl (Si-PFP) is a sorbent primarily used in the separation of molecules bearing fluorine atoms but may also be used in the separation of non-fluorous compoundssuch as Taxol® and its derivatives.2,3 Because of its phenyl ring, Si-PFP has a higher selectivity for aromatics containing molecules compared to the other fluorinated sorbents.

PRODUCT SPECIFICATIONS

MSDS-R67530B

RELATED PUBLICATIONS

  1. J. Chromato. A, 511 (1990) 79
  2. J. Nat. Prod., 61 (1998) 57
  3. J. Chromato. B, 696 (1997) 99

Additional Information

Particle Shape Irregular
Array Pentafluorophenyl (PFP)
Family / Formats SiliaBond® (Functionalized Silicas)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Storage Condition Keep dry