Vinaginsenoside R8(Synonyms: 越南参皂苷R8)

天然产物 糖类和糖苷 Saccharides and Glycosides

Vinaginsenoside R8;(Synonyms: 越南参皂苷R8)

Vinaginsenoside R8,一种从 Panacis majoris 的根茎中分离出来的三萜皂甙。Vinaginsenoside R8 对二磷酸腺苷 (ADP) 诱导的血小板聚集具有活性(IC50=25.18 μM)。

Vinaginsenoside R8(Synonyms: 越南参皂苷R8)

Vinaginsenoside R8 Chemical Structure

CAS No. : 156042-22-7

规格 价格 是否有货
1 mg ¥2860 询问价格 货期
5 mg ¥8570 询问价格 货期

* Please select Quantity before adding items.

生物活性

Vinaginsenoside R8, a triterpenoid glycoside isolated from the rhizomes of Panacis majoris. Vinaginsenoside R8 displays activities against adenosine diphosphate (ADP)-induced platelet aggregation (IC50=25.18 μM)[1].

分子量

963.15

Formula

C48H82O19

CAS 号

156042-22-7

中文名称

越南参皂苷R8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Min Li, et al. Studies on triterpenoid glycosides from rhizomes of Panacis majoris and their antiplatelet aggregation activity. Chemical Research in Chinese Universities.

湘仪L-535R台式大容量冷冻离心机

湘仪L-535R台式大容量冷冻离心机

湘仪L-535R台式大容量冷冻离心机

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:湘仪
生产厂家:湘仪
需求数量:

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品
L-535R台式大容量冷冻离心机仪器特点:
◆采用微机处理器控制转速、温度、时间及LED数字显示或大屏幕液晶显示(LCD)(用户选配)。
◆采用大力矩无刷交流变频电机,启动力矩大,加速/减速时间短。
◆设有超温、超速、电子门锁,等多种安全保护功能;设有三层保护套,安全可靠,确保人身,机器安全。
◆配有多种转子,方便用户选用。
◆进口无氟压缩机组(制冷剂R404a),满足环保要求。
◆适用放射免疫、生物化学、生物制药、血液制品的分离、提纯。
L-535R台式大容量冷冻离心机技术参数:
 
最高转速
 5350r/min
 总功率
 1.5kw
 最大相对离心力
 5030xg
 电源
 Ac220V ±10% 50Hz /15A
 最大容量
 4×750ml
整机噪声
 <65dB(A)
 转速精度
 ±30r/min
重量
 95kg
温度设定范围
 -20℃~+40℃
 温控精度
±1.5℃
 最短升/降速时间
45s/50s
 门锁类型
 电子门锁
 定时范围
 1s~ 99min59s或连续离心
 离心腔直径
 420mm
电机
 交流变频电机
显示屏
 液晶屏/数码屏
制冷系统
 无氟制冷(R404a)
 腔内相对温度
 -20℃~+40℃
转子识别
 ——–
驱动方式
 直接驱动
 外形尺寸
 800×550×430mm(L×W×H)
外包装尺寸
 1000×600×460mm
 
L-535R台式大容量冷冻离心机转子参数:
 

转子
Rotor
容量
Capacity
最高转速
Max.speed
最大相对离心力
Max.RCF
试管尺寸
Tube
试管类型
Tube type
1号角转子
No.1Angle Rotor
6×50ml
5350r/min
5030×g
φ29×105
PP
No.2
水平转子
圆杯
4×500ml
4000r/min
3040×g
 
PP
4×250ml
φ62×124
 
4×3×50ml
φ30×100~130
PP尖底或圆底
4×7×20ml
φ20×100~115
PP
4×9×15ml
φ17×105
PP尖底或圆底
4×19×5ml
φ14×100
真空采血管
方形吊篮
4×4×50ml  
4000r/min
3040×g
φ30×100~130
PP尖底或圆底
4×10×15ml
φ17×105
PP尖底或圆底
4×20×10ml
φ14×100
真空采血管
4×28×5ml
φ14×80~100
真空采血管
4×25×1.5ml
 
Eppendorf管(tube)
挂杯
4×37×7ml
4000r/min
3040×g
φ13×70
G放免管
酶标板吊篮
4×2×96孔
4000r/min
3040×g
 
96孔酶标板
3号酶标板转子
2×2×96孔
4000r/min
2200×g
 
96孔酶标板
4号水平转子
4×750ml
 
 
 
 
4000r/min
 
 
 
 
3500×g
φ98×130
750ml PP离心瓶
4×2×100ml
φ42×100
PP圆底
4×4×50ml  
φ30×100~120
PP尖底或圆底
4×10×20ml
φ20×100~115
PP
4×14×15ml
φ17×120
PP尖底
4×19×15ml
φ17×100~120
PP园底(不带螺盖)
4×24×7ml
φ13×70~100
真空采血管
4×37×5ml
φ13×70
G 、放免管
5号水平转子
 
6×250ml
4200r/min
3500×g
φ62×124
PP平底
6×10×5ml
φ13×100
真空采血管
6×7×10ml
φ14×100
真空采血管
6×6×15ml
φ17×105
G、PP圆底管
6×4×15ml
φ17×120
PP尖底带刻度
6×50ml
φ30×100~120
PP圆底、尖底

 

APTSTAT3-9R

APTSTAT3-9R;

APTSTAT3-9R 是一种特定的 STAT3 结合肽,通过特异性阻断 STAT3 磷酸化来抑制 STAT3 激活和下游信号传导。APTSTAT3-9R 具有抗增殖作用和抗肿瘤活性。

APTSTAT3-9Ramp;;

APTSTAT3-9R Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity[1].

IC50 Target[1]

STAT3

;

体外研究
(In Vitro)

APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549)[1].
APTSTAT3-9R (30 μM; for 2 weeks) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. APTSTAT3-9R has IC50s of 10 to 20 μM in A549, B16F1 and HepG2 cells[1].
APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) effectively inhibits phosphorylation of STAT3 but does not affect the level of AKT phosphorylation, indicating specificity of the aptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

APTSTAT3-9R (8 mg/kg in 50 μL; intratumorally injected every other day for a total of four injections) suppresses tumor growth in 6-week-old female BALB/c nude mice with A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4947.51

Formula

C223H330N80O51

Sequence

His-Gly-Phe-Gln-Trp-Pro-Gly-Ser-Trp-Thr-Trp-Glu-Asn-Gly-Lys-Trp-Thr-Trp-Lys-Gly-Ala-Tyr-Gln-Phe-Leu-Lys-Gly-Gly-Gly-Gly-Ser-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

HGFQWPGSWTWENGKWTWKGAYQFLKGGGGSRRRRRRRRR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Daejin Kim, et al. A Specific STAT3-binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling. Cancer Res. 2014 Apr 15;74(8):2144-51.

88R/ID25 OD29 L100mm-ADVANTEC东洋88R石英纤维滤筒

  • 型号 88R/ID25 OD29 L100mm
  • 品牌 ADVANTEC东洋
  • 【简单介绍】
    品牌 其他品牌 88R石英纤维素滤筒 ID25 OD29 L100mm

    ADVANTEC东洋88R石英纤维滤筒,No.88R石英纤维:烟囱排气采样,不可用于液体过滤。

    ADVANTEC东洋88R石英纤维滤筒

    简介

    ADVANTEC圆筒滤纸 No.88R由细小的石英纤维制成,高纯度,无缝圆筒形滤纸。ADVANTEC No.88R圆筒滤纸主要应用于废气中粉尘浓度的测定,zui高承受温度高达1000℃。未使用氧化铝粘着剂, SOx·NOx等酸性气体和硫酸雾的反应性小,可用于酸性气体中灰尘含量的测量。

    特点及应用

    石英纤维素滤纸筒 – No.88R

      zui高使用温度 1,000℃

      No.88R是锥形的,便于装载成堆叠取样

    用途

    No.88R石英纤维:烟囱排气采样,不可用于液体过滤。

    重量:以每个25x90mm(OD*L)尺寸的套筒重量计算。

    压力损失:以5L/分钟的气体流速,测试25*29mm(OD*L)圆筒滤纸的值。

    尺寸

    内径x外径x长(ID*OD*L):17x20x90,19x23x90,22x25x90,24x28x100,25x29x100,25x30x100,29x33x120,30x35x120,35x40x150,39x45x150,48x53x150,55x60x200,68x75x210 mm


    ADVANTEC东洋88R石英纤维滤筒


    88R/ID25 OD29 L100mm-ADVANTEC东洋88R石英纤维滤筒

     

11R-VIVIT

11R-VIVIT;

11R-VIVIT 是一种活化 T 细胞的细胞通透性核因子 (NFAT) 抑制剂。11R-VIVIT 可用于足细胞和糖尿病肾病的研究。

11R-VIVITamp;;

11R-VIVIT Chemical Structure

CAS No. : 592517-80-1

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1].

IC50 Target

NFAT[1]

体外研究
(In Vitro)

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3573.15

Formula

C147H259N67O36S

CAS 号

592517-80-1

Sequence Shortening

RRRRRRRRRRRGGGMAGPHPVIVITGPHEE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426-439.

R8-T198wt

R8-T198wt;

R8-T198wt 是一种可透过细胞的羧基末端 p27Kip1 肽,通过抑制 Pim-1 激酶而显示抗肿瘤活性。

R8-T198wtamp;;

R8-T198wt Chemical Structure

CAS No. : 2305815-72-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase[1].

体外研究
(In Vitro)

R8-T198wt peptide (KD=323 nM) shows significant affinity for Pim-1. R8-T198wt peptide inhibits p27Kip1 phosphorylation by Pim-1 in cells[1].
R8-T198wt peptide induces G1 arrest and apoptosis in DU145 cells[1].
R8-T198wt treatment also enhances the HA-p27Kip1 expression level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2820.33

Formula

C111H211N59O26S

CAS 号

2305815-72-7

Sequence Shortening

GGGRRRRRRRRGCKKPGLRRRQT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Daisuke Morishita, et al. Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J Biol Chem. 2011 Jan 28;286(4):2681-8.

GB-100R/47mm-日本东洋GB-100R系列玻璃纤维滤纸

  • 型号 GB-100R/47mm
  • 品牌 ADVANTEC东洋
  • 【简单介绍】
    品牌 其他品牌

    日本东洋GB-100R系列玻璃纤维滤纸中含有金属含量zui少的产品,适合于大气中浮游粒子的采样、浓度测量、及成分分析。

    ​玻璃纤维滤纸,100张/盒。适合做空气干燥机的过滤纸,收集效率高,含有金属含量zui少的玻璃纤维滤纸,空气中悬浮颗粒的收集等

    ADVANTEC GB-100R玻璃纤维滤纸适用于大气中悬浮粒子采样、浓度测定及成分分析。

    GB-100R玻璃纤维滤纸由极细的硼硅酸盐玻璃纤维制成,过滤速度快,因沉淀物保留性出色,可短时间内完成高效过滤。zui高使用温度500℃,高强度化学抵抗性,具生物惰性,吸湿性小,存储方便,具有优良的尺寸稳定性,可高温高压消毒。

    ADVANTEC GB-100R是特别为空气采样开发的,收集效率高,玻璃滤纸中含有金属含量zui少的产品,适合于大气中浮游粒子的采样、浓度测量、及成分分析。 

    日本东洋GB-100R系列玻璃纤维滤纸  GB-100R/47mm  订购信息:

    36321024 玻璃纤维滤纸 GB100R/24MM GB100R/24mm直径玻璃纤维滤纸,100张/盒

    36321025 玻璃纤维滤纸 GB100R/25MM GB100R/25mm直径玻璃纤维滤纸,100张/盒

    36321026 玻璃纤维滤纸 GB100R/26MM GB100R/26mm直径玻璃纤维滤纸,100张/盒

    36321031 玻璃纤维滤纸 GB100R/31MM GB100R/31mm直径玻璃纤维滤纸,100张/盒

    36321034 玻璃纤维滤纸 GB100R/34MM GB100R/34mm直径玻璃纤维滤纸,100张/盒

    36321037 玻璃纤维滤纸 GB100R/37MM GB100R/37mm直径玻璃纤维滤纸,100张/盒

    36321040 玻璃纤维滤纸 GB100R/40MM GB100R/40mm直径玻璃纤维滤纸,100张/盒

    36321045 玻璃纤维滤纸 GB100R/45MM GB100R/45mm直径玻璃纤维滤纸,100张/盒

    36321047 玻璃纤维滤纸 GB100R/47MM GB100R/47mm直径玻璃纤维滤纸,100张/盒

    36321055 玻璃纤维滤纸 GB100R/55MM GB100R/55mm直径玻璃纤维滤纸,100张/盒

    36321060 玻璃纤维滤纸 GB100R/60MM GB100R/60mm直径玻璃纤维滤纸,100张/盒

    36321070 玻璃纤维滤纸 GB100R/70MM GB100R/70mm直径玻璃纤维滤纸,100张/盒

    36321080 玻璃纤维滤纸 GB100R/80MM GB100R/80mm直径玻璃纤维滤纸,100张/盒

      玻璃纤维滤纸 GB100R/81MM GB100R/81mm直径玻璃纤维滤纸,100张/盒

    A3632002 玻璃纤维滤纸 GB100R/82MM GB100R/82mm直径玻璃纤维滤纸,100张/盒

    36321090 玻璃纤维滤纸 GB100R/90MM GB100R/90mm直径玻璃纤维滤纸,100张/盒

    36321100 玻璃纤维滤纸 GB100R/100MM GB100R/100mm直径玻璃纤维滤纸,100张/盒

    36321110 玻璃纤维滤纸 GB100R/110MM GB100R/110mm直径玻璃纤维滤纸,100张/盒

    36321125 玻璃纤维滤纸 GB100R/125MM GB100R/125mm直径玻璃纤维滤纸,100张/盒

      玻璃纤维滤纸 GB100R/140MM GB100R/140mm直径玻璃纤维滤纸,100张/盒

    36321150 玻璃纤维滤纸 GB100R/150MM GB100R/150mm直径玻璃纤维滤纸,100张/盒

      玻璃纤维滤纸 GB100R/293MM GB100R/293mm直径玻璃纤维滤纸,50张/盒

    36323203 玻璃纤维滤纸 GB100R/203MMX254MM GB100R/203mmx254mm玻璃纤维滤纸,50张/盒

    A3632001 玻璃纤维滤纸 GB100R/250MMX250MM GB100R/250mmx250mm玻璃纤维滤纸,100张/盒

    36323300 玻璃纤维滤纸 GB100R/300MMX300MM GB100R/300mmx300mm玻璃纤维滤纸,10张/盒

     

ORTODIGICEN20/20R 台式(冷冻)离心机

ORTODIGICEN20/20R 台式(冷冻)离心机

ORTO DIGICEN20/20R 台式(冷冻)离心机

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:中文
生产厂家:ORTO
需求数量:

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

主要特点:

●最新式变频控制技术及免维护无碳刷马达
●微处理器数字控制,带背光LCD显示,所有性能参数一目了然:速度、加速、制动、离心力、温度、时间、设定程序、警示信息和状态显示等
●转头自动识别系统,快速加速,对敏感样品可以选择减速程序
●内部隔离层的使用充分吸收噪音、减少振动,噪音<60dB
●弹性支撑技术确保马达的平稳运转
●安全保护功能
(1)离心机运转过程中机盖无法开启开启机盖后不能启动离心机
(2)转头平衡自动检测,转子失平衡,超载自动检测和报警保护功能
(3)运行错误信息 LCD显示

技术参数:

1.最大转速(rpm):16500
2.最大相对离心力(xg):24959
3.速度调节:100RPM增量
4.时间调节:1-99min],5秒增量
5.温度范围:-20—+40℃;1℃增量

 

荧光染料HKSOX-1r (5/6-mixture)

荧光染料Dye Reagents HKSOX-1r (5/6-mixture); 纯度: 98.68%

HKSOX-1r (5/6-mixture) 是一种荧光探针,用于成像和检测活细胞以及体内的内源性超氧化物。 HKSOX-1r (5/6-mixture) 对超氧阴离子自由基具有极好的选择性和敏感性。

HKSOX-1r (5/6-mixture)amp;;

HKSOX-1r (5/6-mixture) Chemical Structure

规格 价格 是否有货 数量
1 mg ¥3000 In-stock
5 mg ¥9000 In-stock
10 mg ¥15500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

HKSOX-1r (5/6-mixture) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical[1].

体外研究
(In Vitro)

HKSOX-1r (5/6-mixture) (2 μM; 30 min) detects mitochondrial respiratory inhibitor-induced O2•- formation in a highly sensitive and rapid manner in HCT116, BV-2 and RAW264.7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

HKSOX-1r (5/6-mixture) (10 μM; 20 min) detects distinct fluorescence distribution in zebrafish embryos are subjected to challenge of PMA or Antimycin A[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

855.54

Formula

C58H30F20N2O28S4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 20 mg/mL (23.38 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1689 mL 5.8443 mL 11.6885 mL
5 mM 0.2338 mL 1.1689 mL 2.3377 mL
10 mM 0.1169 mL 0.5844 mL 1.1689 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 5 mg/mL (5.84 mM); Clear solution

    此方案可获得 ≥ 5 mg/mL (5.84 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Hu JJ, et, al. Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. J Am Chem Soc. 2015 Jun 3;137(21):6837-43.

荧光染料HKSOX-1r (5/6-mixture)

荧光染料Dye Reagents HKSOX-1r (5/6-mixture); 纯度: 98.68%

HKSOX-1r (5/6-mixture) 是一种荧光探针,用于成像和检测活细胞以及体内的内源性超氧化物。 HKSOX-1r (5/6-mixture) 对超氧阴离子自由基具有极好的选择性和敏感性。

HKSOX-1r (5/6-mixture)

HKSOX-1r (5/6-mixture) Chemical Structure

规格 价格 是否有货 数量
1 mg ¥3000 In-stock
5 mg ¥9000 In-stock
10 mg ¥15500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

HKSOX-1r (5/6-mixture) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical[1].

体外研究
(In Vitro)

HKSOX-1r (5/6-mixture) (2 μM; 30 min) detects mitochondrial respiratory inhibitor-induced O2•- formation in a highly sensitive and rapid manner in HCT116, BV-2 and RAW264.7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

HKSOX-1r (5/6-mixture) (10 μM; 20 min) detects distinct fluorescence distribution in zebrafish embryos are subjected to challenge of PMA or Antimycin A[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

855.54

Formula

C58H30F20N2O28S4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 20 mg/mL (23.38 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1689 mL 5.8443 mL 11.6885 mL
5 mM 0.2338 mL 1.1689 mL 2.3377 mL
10 mM 0.1169 mL 0.5844 mL 1.1689 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 5 mg/mL (5.84 mM); Clear solution

    此方案可获得 ≥ 5 mg/mL (5.84 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Hu JJ, et, al. Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. J Am Chem Soc. 2015 Jun 3;137(21):6837-43.