IFN-α Receptor Recognition Peptide 1(Synonyms: IRRP1)

IFN-α Receptor Recognition Peptide 1;(Synonyms: IRRP1)

IFN-α Receptor Recognition Peptide 1 是 IFN-α 的一个多肽序列,为 IFN-α 受体识别肽。

IFN-α Receptor Recognition Peptide 1amp;;(Synonyms: IRRP1)

IFN-α Receptor Recognition Peptide 1 Chemical Structure

CAS No. : 153840-64-3

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生物活性

IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions[1].

分子量

885.99

Formula

C35H59N13O12S

CAS 号

153840-64-3

Sequence

Cys-Leu-Lys-Asp-Arg-His-Asp

Sequence Shortening

CLKDRHD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Fish EN. Interferon receptor recognition peptides enhance the biological potency of interferon alphas. FEBS Lett. 1995 May 22;365(1):87-91.

A-71915 TFA

A-71915 TFA;

A-71915 (TFA) 是一种选择性的心房利钠肽受体 (ANP receptor) 抑制剂,可诱导 RINm5F 胰腺 β 细胞的凋亡,降低胰岛素的分泌。

A-71915 TFAamp;;

A-71915 TFA Chemical Structure

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生物活性

A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells[1].

分子量

1727.98

Formula

C71H117F3N26O17S2

Sequence Shortening

RC-{Cyclohexyl-Ala}-GGRIDRI-{d-Tic}-RC (Disulfide bridge: Cys2-Cys13)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wong JC, et al. Pancreatic-β-cell survival and proliferation are promoted by protein kinase G type Iα and downstream regulation of AKT/FOXO1. Diab Vasc Dis Res. 2017 Sep;14(5):434-449.

Galanin Receptor Ligand M35 TFA

Galanin Receptor Ligand M35 TFA;

Galanin Receptor Ligand M35 TFA 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM),也是 galanin receptor 拮抗剂。Galanin Receptor Ligand M35 TFA 对人甘丙肽受体 1 型 和 人甘丙肽受体 2 型 的 Ki 值分别为 0.11 nM、2.0 nM。

Galanin Receptor Ligand M35 TFAamp;;

Galanin Receptor Ligand M35 TFA Chemical Structure

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Galanin Receptor Ligand M35 TFA 的其他形式现货产品:

Galanin Receptor Ligand M35

生物活性

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2].

体外研究
(In Vitro)

Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2347.62

Formula

C109H154N27F3O28

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2

Sequence Shortening

GWTLNSAGYLLGPPPGFSPFR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kask K, et al. Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59(3):341-8.

    [2]. Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne). 2012 Dec 7;3:146.

    [3]. Ogren SO, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51(1):1-5.

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide 5 (TRAP-5);

Thrombin Receptor Activator for Peptide 5 (TRAP-5) 又叫作凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5) (Proteinase Activated Receptor 1 (1-5)),可用于冠心病的研究。

Thrombin Receptor Activator for Peptide 5 (TRAP-5)amp;;

Thrombin Receptor Activator for Peptide 5 (TRAP-5) Chemical Structure

CAS No. : 141685-53-2

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1 mg ¥800 询问价格 货期
5 mg ¥1800 询问价格 货期
10 mg ¥2800 询问价格 货期

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生物活性

Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

IC50 Target

Protease-Activated Receptor

分子量

634.77

Formula

C30H50N8O7

CAS 号

141685-53-2

Sequence Shortening

SFLLR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gigante B, et al. Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1213-9.

Neuropeptide Y Y1 receptor antagonist 1

Neuropeptide Y Y1 receptor antagonist 1;

Neuropeptide Y Y1 receptor antagonist 1 (化合物 39),一种荧光探针,是神经肽 Y Y1 受体 (Y1R) 的拮抗剂,Ki 值为 0.19 nM。

Neuropeptide Y Y1 receptor antagonist 1amp;;

Neuropeptide Y Y1 receptor antagonist 1 Chemical Structure

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生物活性

Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y1 receptor (Y1R), with a Ki of 0.19 nM[1].

IC50 Target[1]

NPY Y1 receptor

0.19 nM (Ki)

分子量

1115.28

Formula

C62H70N10O10

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Müller C, et, al. Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y 1 Receptor. J Med Chem. 2022 Mar 24;65(6):4832-4853.

Galanin Receptor Ligand M35

Galanin Receptor Ligand M35; 纯度: 99.65%

Galanin Receptor Ligand M35 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM),也是 galanin receptor 拮抗剂。Galanin Receptor Ligand M35 对人甘丙肽受体 1 型 和 人甘丙肽受体 2 型 的 Ki 值分别为 0.11 nM、2.0 nM。

Galanin Receptor Ligand M35amp;;

Galanin Receptor Ligand M35 Chemical Structure

CAS No. : 142846-71-7

规格 价格 是否有货 数量
1 mg ¥2000 In-stock
5 mg ¥6000 In-stock
10 mg ¥10000 In-stock
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Galanin Receptor Ligand M35 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Endocrinology Compound Library
  • Neurotransmitter Receptor Compound Library
  • Anti-Obesity Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2].

IC50 Target

Kd: 0.1 nM (galanin receptor)[1]
Ki: 0.11 nM (human galanin receptor type 1), 2.0 nM (human galanin receptor type 2)[2]

体外研究
(In Vitro)

Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2233.60

Formula

C107H153N27O26

CAS 号

142846-71-7

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2

Sequence Shortening

GWTLNSAGYLLGPPPGFSPFR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (44.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4477 mL 2.2385 mL 4.4771 mL
5 mM 0.0895 mL 0.4477 mL 0.8954 mL
10 mM 0.0448 mL 0.2239 mL 0.4477 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.12 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.12 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.12 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.12 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.12 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.12 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Kask K, et al. Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59(3):341-8.

    [2]. Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne). 2012 Dec 7;3:146.

    [3]. Ogren SO, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51(1):1-5.