标签归档：pri

P8RI(Synonyms: D-P8RI)

发表于由

P8RI;(Synonyms: D-P8RI) 纯度: 98.19%

P8RI (D-P8RI) 是CD31的模拟肽和 CD31 激动剂。P8RI 与 CD31 外结构域的膜旁氨基酸序列结合，通过恢复 CD31 抑制途径显示出免疫抑制作用。

P8RIamp;;(Synonyms: D-P8RI)

P8RI Chemical Structure

CAS No. : 2147724-76-1

规格 价格 是否有货 数量
5 mg ￥1200 In-stock
10 mg ￥1900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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P8RI 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Peptide Library

生物活性

P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2].

体外研究
(In Vitro)

P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Apo E -/- mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3]
Dosage: 2.5 mg/kg
Administration: Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II)
Result: Aneurysmal transformation was significantly reduced.

分子量

1016.24

Formula

C51H77N13O9
CAS 号

2147724-76-1
Sequence Shortening

KWPALFVR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (98.40 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9840 mL 4.9201 mL 9.8402 mL
5 mM 0.1968 mL 0.9840 mL 1.9680 mL
10 mM 0.0984 mL 0.4920 mL 0.9840 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42(18):1760-1769.

    [2]. Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53(2):746-749.

    [3]. Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72(1):45-57.