P8RI;(Synonyms: D-P8RI) 纯度: 98.19%
P8RI (D-P8RI) 是CD31的模拟肽和 CD31 激动剂。P8RI 与 CD31 外结构域的膜旁氨基酸序列结合,通过恢复 CD31 抑制途径显示出免疫抑制作用。
P8RI Chemical Structure
CAS No. : 2147724-76-1
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1200 | In-stock | |
10 mg | ¥1900 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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P8RI 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Peptide Library
生物活性 |
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2]. |
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体外研究 (In Vitro) |
P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
1016.24 |
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Formula |
C51H77N13O9 |
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CAS 号 |
2147724-76-1 |
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Sequence Shortening |
KWPALFVR |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (98.40 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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