Rubiadin(Synonyms: 茜草素)

发表于2024年5月6日由Whatman官网

天然产物醌类Quinones

Rubiadin (Synonyms: 茜草素) 纯度: 99.29%

Rubiadin 是一种从茜草提取的二羟基蒽醌。Rubiadin 具有有效的抗氧化剂活性。

Rubiadin Chemical Structure

CAS No. : 117-02-2

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Rubiadin 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Phenols Library
Traditional Chinese Medicine Monomer Library

生物活性	Rubiadin is a dihydroxy anthraquinone isolated from Rubia cordifolia. Rubiadin has a potent antixidant activity^[1].
分子量	254.24
Formula	C₁₅H₁₀O₄
CAS 号	117-02-2
中文名称	茜草素
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Tripathi YB, et al. Rubiadin, a new antioxidant from Rubia cordifolia.Indian J Biochem Biophys. 1997 Jun;34(3):302-6.

(Rac)-Arnebin 1(Synonyms: (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin)

发表于2024年5月6日由Whatman官网

天然产物醌类Quinones

(Rac)-Arnebin 1 (Synonyms: (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin)

(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) 是 β,β-Dimethylacrylalkannin 和/或 β,β-Dimethylacrylshikonin 的消旋体。β,β-Dimethylacrylalkannin 和 β,β-Dimethylacrylshikonin 是从紫草属植物中分离得到的萘醌类化合物，β,β-Dimethylacrylshikonin 具有抗肿瘤活性。

(Rac)-Arnebin 1 Chemical Structure

CAS No. : 5162-01-6

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生物活性	(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity^[1].
分子量	370.40
Formula	C₂₁H₂₂O₆
CAS 号	5162-01-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97.

Fuscaxanthone C

发表于2024年5月5日由Whatman官网

天然产物醌类Quinones

Fuscaxanthone C

Fuscaxanthone C 是从黄藤属植物的树皮中分离得到的氧杂蒽酮类化合物。

Fuscaxanthone C Chemical Structure

CAS No. : 15404-76-9

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生物活性	Fuscaxanthone C is an xanthone isolated from the stem bark of Garcinia fusca^[1].
分子量	438.51
Formula	C₂₆H₃₀O₆
CAS 号	15404-76-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ito C, et al. Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity. J Nat Prod. 2003 Feb;66(2):200-5.

Lophanthoidin E

发表于2024年5月5日由Whatman官网

天然产物醌类Quinones

Lophanthoidin E

Lophanthoidin E 是从 Rabdosia lophanthoides 的干叶中分离得到的二萜类化合物。

Lophanthoidin E Chemical Structure

CAS No. : 120462-45-5

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生物活性	Lophanthoidin E is a diterpenoids compound isolated from the dried leaves of Rabdosia lophanthoides^[1].
分子量	406.47
Formula	C₂₂H₃₀O₇
CAS 号	120462-45-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. XuYunlong, et al. Abietane quinones from rabdosia lophanthoides.

1,2,3,7-Tetramethoxyxanthone(Synonyms: 1,2,3,7-四甲氧基口山酮)

发表于2024年5月5日由Whatman官网

天然产物醌类Quinones

1,2,3,7-Tetramethoxyxanthone (Synonyms: 1,2,3,7-四甲氧基口山酮)

1,2,3,7-Tetramethoxyxanthone 是从Polygala tenuifolia 中提取得到的一种氧杂蒽酮类化合物。

1,2,3,7-Tetramethoxyxanthone Chemical Structure

CAS No. : 22804-52-0

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生物活性	1,2,3,7-Tetramethoxyxanthone is a xanthone isolated from Polygala tenuifolia^[1].
分子量	316.31
Formula	C₁₇H₁₆O₆
CAS 号	22804-52-0
中文名称	1,2,3,7-四甲氧基口山酮
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. HanjiroIto, et al. Xanthones and a cinnamic acid derivatives from Polygala tenuifolia. Phytochemistry. 1977, 16 (10):1614-1616.

Questin

发表于2024年5月5日由Whatman官网

天然产物醌类Quinones

Questin

Questin 是从海洋黄曲霉中分离出来的一种抗菌剂。Questin对 V. harveyi，V. anguillarum，V. cholerae 和 V. parahemolyticus 具有抗菌活性，MIC 值分别为 31.25 µg/mL，62.5 µg/mL，62.5 µg/mL 和 125 µg/mL。

Questin Chemical Structure

CAS No. : 3774-64-9

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生物活性	Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against *V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus* with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL^[1].
分子量	284.26
Formula	C₁₆H₁₂O₅
CAS 号	3774-64-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lei Guo, et al. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi. 3 Biotech. 2017 Dec;7(6):383.

Versicolorin A

发表于2024年5月4日由Whatman官网

天然产物醌类Quinones

Versicolorin A

Versicolorin A 是黄曲霉毒素 B₁ (AFB₁) 的前体，可作为黄曲霉毒素污染的早期指标，即使黄曲霉毒素本身以无法检测的水平存在。

Versicolorin A Chemical Structure

CAS No. : 6807-96-1

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生物活性	Versicolorin A, a precursor of aflatoxin B₁ (AFB₁), can serve as an early indicator of aflatoxin (AF) contamination, even when AFs themselves are present at undetectable levels^[1].
分子量	338.27
Formula	C₁₈H₁₀O₇
CAS 号	6807-96-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gauthier T, Duarte-Hospital C, Vignard J, et al. Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells. Environ Int. 2020;137:105568.

6-Hydroxyrubiadin

发表于2024年5月4日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

6-Hydroxyrubiadin

6-Hydroxyrubiadin 是一种天然的蒽酮，是用于炎症和炎症性疾病研究的候选化合物。

6-Hydroxyrubiadin Chemical Structure

CAS No. : 87686-86-0

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生物活性	6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases^[1].
体外研究 (In Vitro)	6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages^[1]. 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	270.24
Formula	C₁₅H₁₀O₅
CAS 号	87686-86-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yanting Wu, et al. In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):107-116.

Altertoxin I(Synonyms: Dihydroalterperylenol)

发表于2024年5月4日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

Altertoxin I (Synonyms: Dihydroalterperylenol)

Altertoxin I (Dihydroalterperylenol) 是由 Alternaria alternata 产生的一种醌类真菌毒素，具有诱变作用和细胞毒性，能较弱地干扰代谢通讯。

Altertoxin I Chemical Structure

CAS No. : 56258-32-3

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生物活性	Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication^[1].
分子量	352.34
Formula	C₂₀H₁₆O₆
CAS 号	56258-32-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Jarolim K, et al. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II. Arch Toxicol. 2017 Jan;91(1):203-216. [2]. Boutin BK, et al. Effects of purified altertoxins I, II, and III in the metabolic communication V79 system. J Toxicol Environ Health. 1989;26(1):75-81. [3]. Stack ME, et al. Mutagenicity of the Alternaria metabolites altertoxins I, II, and III. Appl Environ Microbiol. 1986 Oct;52(4):718-22.

2-Hydroxyanthraquinone

发表于2024年5月4日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

2-Hydroxyanthraquinone 纯度: ≥98.0%

2-Hydroxyanthraquinone 是一种天然产物，具有抗肿瘤和免疫抑制活性。

2-Hydroxyanthraquinone Chemical Structure

CAS No. : 605-32-3

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2-Hydroxyanthraquinone 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Anti-Cancer Compound Library
Fragment Library
Traditional Chinese Medicine Monomer Library

生物活性

2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity^[1].

分子量

224.21

Formula

C₁₄H₈O₃

CAS 号

605-32-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (446.01 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4601 mL	22.3005 mL	44.6010 mL
5 mM	0.8920 mL	4.4601 mL	8.9202 mL
10 mM	0.4460 mL	2.2301 mL	4.4601 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.15 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (11.15 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (11.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. I Hilgert, et al. Antitumour and immunosuppressive activity of hydroxyanthraquinones and their glucosides. Folia Biol (Praha). 1977;23(2):99-109.

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分类目录归档：天然产物醌类

Rubiadin(Synonyms: 茜草素)

Rubiadin 相关产品

•相关化合物库:

(Rac)-Arnebin 1(Synonyms: (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin)

Fuscaxanthone C

Lophanthoidin E

1,2,3,7-Tetramethoxyxanthone(Synonyms: 1,2,3,7-四甲氧基口山酮)

Questin

Versicolorin A

6-Hydroxyrubiadin

Altertoxin I(Synonyms: Dihydroalterperylenol)

2-Hydroxyanthraquinone

2-Hydroxyanthraquinone 相关产品

•相关化合物库:

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