PD-1/PD-L1-IN 3 TFA

PD-1/PD-L1-IN 3 TFA;

PD-1/PD-L1-IN 3 TFA,一种大环肽,是一种有效和选择性的 PD-1/PD-L1CD80/PD-L1 的相互作用抑制剂。PD-1/PD-L1-IN 3 TFA 通过与 PD-L1 结合来干扰 PD-L1 与 PD-1 和 CD80 的结合,IC50 值分别为 5.60 nM 和 7.04 nM。PD-1/PD-L1-IN 3 TFA 可用于各种疾病的研究,包括癌症和传染病。详细信息请参考专利文献 WO2014151634A1 中的化合物 No.1。

PD-1/PD-L1-IN 3 TFAamp;;

PD-1/PD-L1-IN 3 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases[1].

IC50 Target

IC50: 5.60 nM (PD-1/PD-L1); 7.04 nM (CD80/PD-L1)[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN 3 (0.1 nM-10 μM) inhibits the binding of PD-1 and CD80 to PD-L1, with IC50s of 5.60 nM and 7.04 nM[1].
PD-1/PD-L1-IN 3 blocks the binding of recombinant PD-L1-Ig to Jurkat-PD-1 cells, and also block binding of recombinant PD-1-Ig to either L2987 or LK35.2-hPD-L1, with IC50s of 26 nM, 12 nM, and 3.5 nM, respectively[1].
PD-1/PD-L1-IN 3 (0.001-100 μM) promotes IFN secretion by CMV-specific T cells in a dose-dependent manner, with an EC50 of 400 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1966.19

Formula

C91H127F3N24O20S

Sequence Shortening

Maa-FANPHL-Sar-WSW-Nle-Nle-RCG (Disulfide bridge: Maa1-Cys15)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. MILLER, Michael Matthew, et al. Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions. WO2014151634A1.

湘仪L530 NO1多管架自动平衡离心机转子

湘仪L530 NO1多管架自动平衡离心机转子

湘仪L530 NO1多管架自动平衡离心机转子

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L530多管架自动平衡离心机转子

L530转子参数:

最高转速(r/min):5300

最大相对离心力(*g):5010

容量:4*50ml

湘仪L530 NO2多管架自动平衡离心机转子

湘仪L530 NO2多管架自动平衡离心机转子

湘仪L530 NO2多管架自动平衡离心机转子

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L530多管架自动平衡离心机转子

L530转子参数:

最高转速(r/min):4000

最大相对离心力(*g):2200

容量:2*2*96孔

湘仪L530 NO3多管架自动平衡离心机转子

湘仪L530 NO3多管架自动平衡离心机转子

湘仪L530 NO3多管架自动平衡离心机转子

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:湘仪
生产厂家:湘仪
需求数量:

  • 产品概览
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  • 订购信息
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L530多管架自动平衡离心机转子

L530转子参数:

最高转速(r/min):4200

最大相对离心力(*g):3550

容量:4*250ml/4*10*5ml/4*7*10ml

Human PD-L1 inhibitor IV

Human PD-L1 inhibitor IV;

Human PD-L1 inhibitor IV 是一种竞争性的 human PD-1 protein 抑制剂,Kd 值为 1.38 μM,可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor IVamp;;

Human PD-L1 inhibitor IV Chemical Structure

CAS No. : 2135542-83-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 1.38 μM (Human PD-1 protein)[1]

分子量

1856.90

Formula

C80H113N25O27

CAS 号

2135542-83-3

Sequence Shortening

GNWDYNSQRAQLYNQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

Human PD-L1 inhibitor II

Human PD-L1 inhibitor II;

Human PD-L1 inhibitor II 是有效 PD-L1 抑制剂,具有抗癌活性。

Human PD-L1 inhibitor IIamp;;

Human PD-L1 inhibitor II Chemical Structure

CAS No. : 2135542-85-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity[1].

分子量

2219.45

Formula

C103H151N25O30

CAS 号

2135542-85-5

Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Leu-Glu-Glu-Leu-Arg-Glu-Lys-Ala-Lys-Tyr-Lys

Sequence Shortening

FNWDYSLEELREKAKYK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Honglin Li, et al. Pd-1 targeting polypeptide and use thereof. WO2017162208A1

湘仪L535-1低速离心机

湘仪L535-1低速离心机

湘仪L535-1低速离心机

产品编号:
市场价:¥0.00
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L535-1低速离心机仪器特点:
◆采用微机处理器控制转速、温度、时间及LED数字显示或大屏幕液晶显示(LCD)(用户选配)。
◆采用大力矩无刷交流变频电机,启动力矩大,加速/减速时间短。
◆设有超温、超速、电子门锁,等多种安全保护功能;设有三层保护套,安全可靠,确保人身,机器安全。
◆配有多种转子,方便用户选用。
◆进口无氟压缩机组(制冷剂R404a),满足环保要求。
◆适用放射免疫、生物化学、生物制药、血液制品的分离、提纯。
L535-1低速离心机技术参数:

最高转速
 5350r/min
 总功率
 0.8kw
 最大相对离心力
 5030xg
 电源
 Ac220V ±10% 50Hz /15A
 最大容量
 4×750ml
整机噪声
 <65dB(A)
 转速精度
 ±30r/min
重量
 18kg
温度设定范围
 常温
 温控精度
—–
 最短升/降速时间
45s/50s
 门锁类型
 电子门锁
 定时范围
 1s~ 99min59s或连续离心
 离心腔直径
 280mm
电机
 交流变频电机
显示屏
液晶/数码屏
记忆功能
 腔内相对温度
 常温+5℃
转子识别
——
驱动方式
 直接驱动
 外形尺寸
 840×650×550mm(L×W×H)
外包装尺寸
960×760×670mm
L535-1低速离心机转子参数:
 
转子
Rotor
容量
Capacity
最高转速
Max.speed
最大相对离心力
Max.RCF
试管尺寸
Tube
试管类型
Tube type
1号角转子
No.1Angle Rotor
6×50ml
5350r/min
5030×g
φ29×105
PP
No.2
水平转子
圆杯
4×500ml
4000r/min
3040×g
 
PP
4×250ml
φ62×124
 
4×3×50ml
φ30×100~130
PP尖底或圆底
4×7×20ml
φ20×100~115
PP
4×9×15ml
φ17×105
PP尖底或圆底
4×19×5ml
φ14×100
真空采血管
方形吊篮
4×4×50ml  
4000r/min
3040×g
φ30×100~130
PP尖底或圆底
4×10×15ml
φ17×105
PP尖底或圆底
4×20×10ml
φ14×100
真空采血管
4×28×5ml
φ14×80~100
真空采血管
4×25×1.5ml
 
Eppendorf管(tube)
挂杯
4×37×7ml
4000r/min
3040×g
φ13×70
G放免管
酶标板吊篮
4×2×96孔
4000r/min
3040×g
 
96孔酶标板
3号酶标板转子
2×2×96孔
4000r/min
2200×g
 
96孔酶标板
4号水平转子
4×750ml
 
 
 
 
4000r/min
 
 
 
 
3500×g
φ98×130
750ml PP离心瓶
4×2×100ml
φ42×100
PP圆底
4×4×50ml  
φ30×100~120
PP尖底或圆底
4×10×20ml
φ20×100~115
PP
4×14×15ml
φ17×120
PP尖底
4×19×15ml
φ17×100~120
PP园底(不带螺盖)
4×24×7ml
φ13×70~100
真空采血管
4×37×5ml
φ13×70
G 、放免管
5号水平转子
 
6×250ml
4200r/min
3500×g
φ62×124
PP平底
6×10×5ml
φ13×100
真空采血管
6×7×10ml
φ14×100
真空采血管
6×6×15ml
φ17×105
G、PP圆底管
6×4×15ml
φ17×120
PP尖底带刻度
6×50ml
φ30×100~120
PP圆底、尖底

湘仪L500台式低速自动平衡离心机

湘仪L500台式低速自动平衡离心机

湘仪L500台式低速自动平衡离心机

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:湘仪
生产厂家:湘仪
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L500 台式低速自动平衡离心机是本公司技术人员集多年离心机开发经验,为满足临床医学对离心机的新要求而设计开发的最新产品
L500 台式低速自动平衡离心机仪器特点:
◆新颖独特的全不锈钢水平转子(已申请国家专利)
◆多种不锈钢管架,更换方便
◆加/减速时间短,加速时间小于30s,减速时间小于35s
可以选择不同的升,降速显示。
◆采用微机控制,数码管显示(LED)或大屏幕液晶显示(LCD)(用户选配),无刷直流电机驱动,10个用户程序贮存。
◆电子门锁、不锈钢内腔。
◆设RCF建,随时观察离心机,运行中可任意修改参数。

L500台式低速自动平衡离心机技术参数:
 
最高转速
 5000r/min
 总功率
 0.3kw
 最大相对离心力
4100xg
 电源
 Ac220V 50Hz 5A
 最大容量
 24×10ml
整机噪声
 <65dB(A)
 转速精度
 ±30r/min
重量
 15kg
温度设定范围
 常温
 温控精度
—–
 最短升/降速时间
30/35S
 门锁类型
 电子门锁
 定时范围
 0~99min
 离心腔直径
 320mm
电机
 直流无刷电机
显示屏
         液晶/数码屏
记忆功能
 腔内相对温度
 常温+5℃
转子识别
——
驱动方式
 直接驱动
 外形尺寸
 432×370×250mm(L×W×H)
外包装尺寸
 575×433×312mm
 
 
 
L500台式低速自动平衡离心机转子参数:
型号
转子名称
最高转速
最大相对
离心力
容   量
备注
No1
角转子
4000
2580
24×10ml
另购
NO2
水平转子
5000
4100
12×15ml
另购

24×5ml

Human PD-L1 inhibitor V

Human PD-L1 inhibitor V;

Human PD-L1 inhibitor V 是一种 human PD-1 protein 结合肽,Kd 值为 3.32 μM,可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor Vamp;;

Human PD-L1 inhibitor V Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Human PD-L1 inhibitor V 的其他形式现货产品:

Human PD-L1 inhibitor V TFA

生物活性

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 3.32 μM (Human PD-1 protein)[1]

体外研究
(In Vitro)

Human PD-L1 inhibitor V (Ar5M_2) is a peptide designed with anchor residues Y56, R113, A121, D122 and Y123[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1485.71

Formula

C65H104N20O18S

Sequence

Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln

Sequence Shortening

LDYVNRRKMYQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

Human PD-L1 inhibitor I

Human PD-L1 inhibitor I;

Human PD-L1 inhibitor I 是一种 hPD-1 肽配体,KD 值为 3.39 μM。Human PD-L1 inhibitor I 可能可以干扰 hPD-L1 与 hPD-1 的结合。

Human PD-L1 inhibitor Iamp;;

Human PD-L1 inhibitor I Chemical Structure

CAS No. : 2135542-86-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor I is a hPD-1 peptide ligand, with a KD of 3.39 μM. Human PD-L1 inhibitor I may disturb the binding of hPD-L1 to hPD-1[1].

分子量

2350.58

Formula

C110H152N26O32

CAS 号

2135542-86-6

Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Trp-Lys-Ser-Glu-Arg-Leu-Lys-Glu-Ala-Tyr-Asp-Leu

Sequence Shortening

FNWDYSWKSERLKEAYDL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tianyu Wang, et al. Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway. J Med Chem. 2019 Feb 28;62(4):1715-1730.