标签归档：pd

TPP-1 TFA

发表于由

TPP-1 TFA;

TPP-1 TFA 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 TFA 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 TFA 通过再激活 T 细胞功能抑制肿瘤生长。

TPP-1 TFAamp;;

TPP-1 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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TPP-1 TFA 的其他形式现货产品:

TPP-1

生物活性

TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function[1].

体外研究
(In Vitro)

TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TPP-1 TFA (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1 TFA-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 TFA has no effect on the growth of the H460-luc tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5- to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32 days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. 

分子量

2602.69

Formula

C109H151F3N34O34S2
Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6(2):178-188.

Creastar Pd-EX 品牌：Chemicrea

发表于由

Creastar Pd-EX

品牌：Chemicrea
CAS No.：201849-07-2
储存条件：室温
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

306-96102

 – 25 g –

Creastar Pd-EX 品牌：Chemicrea

替代品：308-96101

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

BMSpep-57

发表于由

BMSpep-57;

BMSpep-57 是一种有效的大环肽类抑制剂，抑制 PD-1/PD-L1 相互作用，IC50 为 7.68 nM。BMSpep-57 与 PD-L1 结合，MST 和 SPR 测定表明，Kd 分别为 19 nM 和 19.88 nM。BMSpep-57 通过增加 PBMC 中 IL-2 的产生促进 T 细胞功能。

BMSpep-57amp;;

BMSpep-57 Chemical Structure

CAS No. : 1629655-80-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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BMSpep-57 的其他形式现货产品:

BMSpep-57 hydrochloride

生物活性

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]
体外研究
(In Vitro)

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in  SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1868.17

Formula

C89H126N24O19S
CAS 号

1629655-80-6
Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9(1):12392.

Human PD-L1 inhibitor I

发表于由

Human PD-L1 inhibitor I;

Human PD-L1 inhibitor I 是一种 hPD-1 肽配体，KD 值为 3.39 μM。Human PD-L1 inhibitor I 可能可以干扰 hPD-L1 与 hPD-1 的结合。

Human PD-L1 inhibitor Iamp;;

Human PD-L1 inhibitor I Chemical Structure

CAS No. : 2135542-86-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Human PD-L1 inhibitor I is a hPD-1 peptide ligand, with a KD of 3.39 μM. Human PD-L1 inhibitor I may disturb the binding of hPD-L1 to hPD-1[1].

分子量

2350.58

Formula

C110H152N26O32
CAS 号

2135542-86-6
Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Trp-Lys-Ser-Glu-Arg-Leu-Lys-Glu-Ala-Tyr-Asp-Leu
Sequence Shortening

FNWDYSWKSERLKEAYDL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tianyu Wang, et al. Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway. J Med Chem. 2019 Feb 28;62(4):1715-1730.

Human PD-L1 inhibitor III

发表于由

Human PD-L1 inhibitor III;

Human PD-L1 inhibitor III 是人的 PD-L1 的抑制剂。

Human PD-L1 inhibitor IIIamp;;

Human PD-L1 inhibitor III Chemical Structure

CAS No. : 2135542-84-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Human PD-L1 inhibitor III is a human PD-L1 inhibitor.

分子量

2223.70

Formula

C97H155N29O29S1
CAS 号

2135542-84-4
Sequence Shortening

TEKDYRHGNIRMKLAYDL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

GE PD SpinTrap G-25预装脱盐柱28918004

发表于由

GE PD SpinTrap G-25预装脱盐柱28918004                                                              

PD SpinTrap G-25是一次性微量离心层析柱，用于对分子量大于5000的生物大分子纯化除杂质。为生物样品的脱盐和缓冲液置换而设计，与微量离心机配套使用。柱子预装500ul Sephadex G-25填料，柱材料为生物兼容性的聚丙烯。

1、用于对蛋白和其他大生物分子（分子量大于5000）进行小规模的除杂，可以平行操作多个样品

2、高效脱盐、缓冲液置换、除小分子化合物

3、重现性好，高通量，平行除杂处理蛋白样品

4、能制备70-130ul的样品，无稀释

基质：高度交联6%的葡聚糖。分离原理：凝胶过滤。平均颗粒大小：85-260um。排阻限度：分子量5000。样品体积：70-130ul。脱盐率：大于85%。工作PH范围：2-13.

GE PD SpinTrap G-25预装脱盐柱28918004                                                           

millipore滤膜盒PD1504700​ PD1504700​

发表于由

millipore滤膜盒PD1504700​

millipore滤膜盒PetriSlide污染分析培养皿PD1504700 壁厚：0.3（mm）长度：76（mm） 高度：5（mm） 宽度：51（mm） millipore滤膜盒PetriSlide污染分析培养皿PD1504700 数量/包装: 100

millipore滤膜盒PetriSlide污染分析培养皿PD1504700

塑料材质：PC

是否有盖：有盖

颜色：透明

壁厚：0.3（mm）
长度：76（mm） 

高度：5（mm）

宽度：51（mm）
数量/包装: 100

主要应用    
Environmental Analysis
生物信息
无菌性:非无菌
材料信息
化学    
Polystyrene (PS)
Cellulose Pad
包装信息
数量:100

GE/whatman沃特曼PD-10脱盐层析色谱柱 17085101

发表于由

GE/whatman沃特曼PD-10脱盐层析色谱柱

简要描述：

GE/whatman沃特曼PD-10脱盐层析色谱柱G-25填料

PD-10脱盐层析柱与一个方便的直立层析柱架一起提供。使用LabMate缓冲液储液器使柱平衡过程更容易进行。

•  快速、高回收率的脱盐和缓冲液置换，也可用于除小分子化合物；预装Sephadex G-25填料。

•  操作灵活，可用离心或重力流。

•  容易使用，便于平衡、上样、洗脱。

•  重力流方式样品量1-2.5ml；离心方式样品量1.75-2.5ml。平行处理多个待脱盐样品，可除去90%以上盐离子。

•  蛋白回收率在70%-95%。

•  LabMate Buffer Reservoir使得平衡PD-10层析柱更容易，更方便。

PD-10层析柱提供了一个经济、方便的选择，可取代冗长、繁琐的透析过程。几分钟内，完成生物样品脱盐、小分子可溶物的去除或替换，同时有*的回收率。

Disposable PD-10 Desalting Columns经过改进设计，能应用于两种新操作方式：重力流和离心，更为灵活方便。重力流操作可选用一到数根柱子，平行操作多个样品进行除杂处理，而无需纯化设备。离心操作则能以标准的离心程序平行处理洗脱样品，将样品稀释降低到zui少。

每个包装内含有四个接头，方便连接配置。与LabMate Buffer Reservoir（需另行购买）联合使用进行重力流操作时，清洗和平衡用的缓冲液能在同一步中加入。

如需要设计经济适用，通用性好的制备样品工艺，推荐购买PD-10 columns和批量包装的填料。

Disposable PD-10脱盐预装层析柱每盒有30根。每根柱均保存在含有0.15% Kathon CG保护剂的蒸馏水中。颗粒大小为20-85μm的填料填充在两个烧结的聚乙烯熔块中。熔块保护填料免于在重力缓冲液流下而干柱。层析柱的出口用可重复使用的帽封口。

重力流操作，从BSA中除去NaCl。样品回收率95%，除盐99%以上。

PD-10 Desalting Columns能以重力流或离心方式快速脱盐。蓝色接头用于离心操作

GE/whatman沃特曼PD-10脱盐层析色谱柱G-25填料

详细信息：

GE/whatman沃特曼PD-10脱盐层析色谱柱 17085101


ADVANTEC东洋消毒培养皿PD-47A

发表于由

ADVANTEC东洋消毒培养皿

简要描述：

培养皿
聚苯乙烯培养皿适合用于47mm直径滤膜的微生物培养
便利：密封设计防止培养时发生干燥，一致的边缘和凸出的圆边，提供方便的操作和牢固的叠起。
供应有垫或没有垫：47mm吸收纤维素垫（0.85±0.17mm厚，吸收1.8-2.2ml液体）
制造商证书（要求时可提供）。
ADVANTEC东洋消毒培养皿  PD-47A

订购信息：
42004010  PD-47A  消毒培养皿，已消毒    100个/盒  54mm直径x11mm高度
42001020  PD-47B  消毒培养皿，带吸收垫，已消毒，100个/盒

1-Caffeoylquinic acid

发表于由

天然产物 黄酮类 Flavonoids

1-Caffeoylquinic acid  纯度: ≥98.0%

1-Caffeoylquinic acid 1-咖啡酰奎宁酸是一种有效的 NF-κB 抑制剂，对 p105 的 RH 结构域显示高结合亲和力，Ki 值为 0.002 μM，结合能为 1.50 Kcal/mol。1-Caffeoylquinic acid 具有抗氧化应激能力。 1-Caffeoylquinic acid 抑制 PD-1/PD-L1 相互作用。

1-Caffeoylquinic acid

1-Caffeoylquinic acid Chemical Structure

CAS No. : 1241-87-8

规格 价格 是否有货 数量
1 mg ￥1710 In-stock
5 mg ￥5140 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

1-Caffeoylquinic acid 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Differentiation Inducing Compound Library
  • Oxygen Sensing Compound Library
  • Phenols Library
  • Pyroptosis Compound Library
  • Flavonoids Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library

生物活性

1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3].

IC50 & Target

Ki: 0.002 μM (1-Caffeoylquinic acid)[1]
分子量

354.31

Formula

C16H18O9
CAS 号

1241-87-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (705.60 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8224 mL 14.1119 mL 28.2239 mL
5 mM 0.5645 mL 2.8224 mL 5.6448 mL
10 mM 0.2822 mL 1.4112 mL 2.8224 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Khan MK, et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7.

    [2]. Jiang Y, et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320.

    [3]. Han Y, et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56.