Human PD-L1 inhibitor II

Human PD-L1 inhibitor II;

Human PD-L1 inhibitor II 是有效 PD-L1 抑制剂,具有抗癌活性。

Human PD-L1 inhibitor IIamp;;

Human PD-L1 inhibitor II Chemical Structure

CAS No. : 2135542-85-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity[1].

分子量

2219.45

Formula

C103H151N25O30

CAS 号

2135542-85-5

Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Leu-Glu-Glu-Leu-Arg-Glu-Lys-Ala-Lys-Tyr-Lys

Sequence Shortening

FNWDYSLEELREKAKYK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Honglin Li, et al. Pd-1 targeting polypeptide and use thereof. WO2017162208A1

anti-PD-1 (mouse), mAb (blocking) (1H10) 抗-PD-1(小鼠),多抗(封闭)(1H10) 品牌:Adipogen


anti-PD-1 (mouse), mAb (blocking) (1H10)

抗-PD-1(小鼠),多抗(封闭)(1H10)

品牌:Adipogen
CAS No.:
储存条件:-20°C
纯度:>95% (SDS-PAGE)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-20B-0075-C100

100 µg 2,280.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free) 抗-PD-1(小鼠),多抗(封闭)(1H10)(不含防腐剂) 品牌:Adipogen


anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free)

抗-PD-1(小鼠),多抗(封闭)(1H10)(不含防腐剂)

品牌:Adipogen
CAS No.:
储存条件:-20°C
纯度:>95% (SDS-PAGE)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-20B-0075PF-C100

100 µg 2,280.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free) 抗-PD-1(小鼠),多抗(封闭)(1H10)(不含防腐剂) 品牌:Adipogen


anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free)

抗-PD-1(小鼠),多抗(封闭)(1H10)(不含防腐剂)

品牌:Adipogen
CAS No.:
储存条件:-20°C
纯度:>95% (SDS-PAGE)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-20B-0075PF-C500

500 µg 3,600.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

PD1504700-默克密理博滤膜盒PetriSlide污染分析培养皿

  • 型号 PD1504700
  • 品牌 Merck Millipore密理博
  • 【简单介绍】

    默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700
    millipore培养皿用于污染分析PD1504700,培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。无菌存储和检查容器适合在 47mm 膜(附带吸收垫)上培养微生物。

     默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700

     

    millipore滤膜盒PetriSlide污染分析培养皿
    millipore培养皿用于污染分析PD1504700,培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。无菌存储和检查容器适合在 47mm 膜(附带吸收垫)上培养微生物。
    millipore滤膜盒PetriSlide污染分析培养皿

    描述
    产品目录编号:PD1504700
    商名    
    Petrislides
    描述:用于污染分析的 PetriSlide
    产品信息
    装置颜色:无色

    millipore滤膜盒PetriSlide污染分析培养皿

    塑料材质:PC是否有盖:有盖
    型号:PD1504700颜色:透明 壁厚:0.3(mm)
    长度:76(mm) 高度:5(mm)宽度:51(mm)
    数量/包装: 100

     默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700
    主要应用    
    Environmental Analysis
    生物信息
    无菌性:非无菌
    材料信息
    化学    
    Polystyrene (PS)
    Cellulose Pad
    包装信息
    数量:100

CD279 [PD-1] (human):Fc (mouse) (rec.) CD279[PD-1](人):Fc(小鼠)(重组) 品牌:Chimerigen


CD279 [PD-1] (human):Fc (mouse) (rec.)

CD279[PD-1](人):Fc(小鼠)(重组)

品牌:Chimerigen
CAS No.:
储存条件:-20°C
纯度:>98% (SDS-PAGE)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

CHI-HF-211PD1-C100

100 µg 5,040.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

PD1504700-密理博滤膜盒直径47mm PD1504700

产品型号PD1504700

品       牌密理博

厂商性质代理商

产品简介

材料:注塑聚苯乙烯器皿;纯纤维素垫
尺寸:51 x 76mm,底座
说明: 用于污染分析的 PetriSlide
商标名: Petrislides
数量/包装: 100
密理博滤膜盒直径47mm PD1504700

详情介绍

millipore PD1504700 用于污染分析的 PetriSlide 代替空培养皿用于微生物分析的 PetriSlides™ 器皿 培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。

millipore PD1504700 用于污染分析的 PetriSlide 代替空培养皿的详细介绍

millipore PD1504700 用于污染分析的 PetriSlide  代替空培养皿
用于微生物分析的 PetriSlides™ 器皿

培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。
用于微生物分析的 PetriSlides™ 器皿

培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。

Human PD-L1 inhibitor V

Human PD-L1 inhibitor V;

Human PD-L1 inhibitor V 是一种 human PD-1 protein 结合肽,Kd 值为 3.32 μM,可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor Vamp;;

Human PD-L1 inhibitor V Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Human PD-L1 inhibitor V 的其他形式现货产品:

Human PD-L1 inhibitor V TFA

生物活性

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 3.32 μM (Human PD-1 protein)[1]

体外研究
(In Vitro)

Human PD-L1 inhibitor V (Ar5M_2) is a peptide designed with anchor residues Y56, R113, A121, D122 and Y123[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1485.71

Formula

C65H104N20O18S

Sequence

Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln

Sequence Shortening

LDYVNRRKMYQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

TPP-1 TFA

TPP-1 TFA;

TPP-1 TFA 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 TFA 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中,TPP-1 TFA 通过再激活 T 细胞功能抑制肿瘤生长。

TPP-1 TFAamp;;

TPP-1 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TPP-1 TFA 的其他形式现货产品:

TPP-1

生物活性

TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function[1].

体外研究
(In Vitro)

TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

TPP-1 TFA (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1 TFA-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 TFA has no effect on the growth of the H460-luc tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5- to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32 days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. 

分子量

2602.69

Formula

C109H151F3N34O34S2

Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6(2):178-188.

Creastar Pd-EX 品牌:Chemicrea


Creastar Pd-EX

品牌:Chemicrea
CAS No.:201849-07-2
储存条件:室温
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

306-96102

25 g

Creastar Pd-EX                                                                品牌:Chemicrea

替代品:308-96101


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。