标签归档：pd

Human PD-L1 inhibitor IV

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Human PD-L1 inhibitor IV;

Human PD-L1 inhibitor IV 是一种竞争性的 human PD-1 protein 抑制剂，Kd 值为 1.38 μM，可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor IVamp;;

Human PD-L1 inhibitor IV Chemical Structure

CAS No. : 2135542-83-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 1.38 μM (Human PD-1 protein)[1]
分子量

1856.90

Formula

C80H113N25O27
CAS 号

2135542-83-3
Sequence Shortening

GNWDYNSQRAQLYNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

Human PD-L1 inhibitor II

发表于由

Human PD-L1 inhibitor II;

Human PD-L1 inhibitor II 是有效 PD-L1 抑制剂，具有抗癌活性。

Human PD-L1 inhibitor IIamp;;

Human PD-L1 inhibitor II Chemical Structure

CAS No. : 2135542-85-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity[1].

分子量

2219.45

Formula

C103H151N25O30
CAS 号

2135542-85-5
Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Leu-Glu-Glu-Leu-Arg-Glu-Lys-Ala-Lys-Tyr-Lys
Sequence Shortening

FNWDYSLEELREKAKYK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Honglin Li, et al. Pd-1 targeting polypeptide and use thereof. WO2017162208A1

PD1504700-默克密理博滤膜盒PetriSlide污染分析培养皿

发表于由
  • 型号 PD1504700
  • 品牌 Merck Millipore密理博
  • 【简单介绍】

    默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700
    millipore培养皿用于污染分析PD1504700,培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。无菌存储和检查容器适合在 47mm 膜（附带吸收垫）上培养微生物。

     默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700

     

    millipore滤膜盒PetriSlide污染分析培养皿
    millipore培养皿用于污染分析PD1504700,培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。无菌存储和检查容器适合在 47mm 膜（附带吸收垫）上培养微生物。
    millipore滤膜盒PetriSlide污染分析培养皿

    描述
    产品目录编号:PD1504700
    商名    
    Petrislides
    描述:用于污染分析的 PetriSlide
    产品信息
    装置颜色:无色

    millipore滤膜盒PetriSlide污染分析培养皿

    塑料材质：PC是否有盖：有盖
    型号：PD1504700颜色：透明 壁厚：0.3（mm）
    长度：76（mm） 高度：5（mm）宽度：51（mm）
    数量/包装: 100

     默克密理博滤膜盒PetriSlide污染分析培养皿 PD1504700
    主要应用    
    Environmental Analysis
    生物信息
    无菌性:非无菌
    材料信息
    化学    
    Polystyrene (PS)
    Cellulose Pad
    包装信息
    数量:100

PD1504700-密理博滤膜盒直径47mm PD1504700

发表于由

产品型号PD1504700

品       牌密理博

厂商性质代理商

产品简介

材料：注塑聚苯乙烯器皿；纯纤维素垫
尺寸：51 x 76mm，底座
说明: 用于污染分析的 PetriSlide
商标名: Petrislides
数量/包装: 100
密理博滤膜盒直径47mm PD1504700

详情介绍

millipore PD1504700 用于污染分析的 PetriSlide 代替空培养皿用于微生物分析的 PetriSlides™ 器皿 培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。

millipore PD1504700 用于污染分析的 PetriSlide 代替空培养皿的详细介绍

millipore PD1504700 用于污染分析的 PetriSlide  代替空培养皿
用于微生物分析的 PetriSlides™ 器皿

培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。
用于微生物分析的 PetriSlides™ 器皿

培养皿替代品。 将滤膜固定到位。 透明盖不用拆卸即可进行精微检查。 圆角矩形底座适合于安装在显微镜镜台上。

Human PD-L1 inhibitor V

发表于由

Human PD-L1 inhibitor V;

Human PD-L1 inhibitor V 是一种 human PD-1 protein 结合肽，Kd 值为 3.32 μM，可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor Vamp;;

Human PD-L1 inhibitor V Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Human PD-L1 inhibitor V 的其他形式现货产品:

Human PD-L1 inhibitor V TFA

生物活性

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 3.32 μM (Human PD-1 protein)[1]
体外研究
(In Vitro)

Human PD-L1 inhibitor V (Ar5M_2) is a peptide designed with anchor residues Y56, R113, A121, D122 and Y123[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1485.71

Formula

C65H104N20O18S
Sequence

Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln
Sequence Shortening

LDYVNRRKMYQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

TPP-1 TFA

发表于由

TPP-1 TFA;

TPP-1 TFA 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 TFA 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 TFA 通过再激活 T 细胞功能抑制肿瘤生长。

TPP-1 TFAamp;;

TPP-1 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TPP-1 TFA 的其他形式现货产品:

TPP-1

生物活性

TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function[1].

体外研究
(In Vitro)

TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TPP-1 TFA (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1 TFA-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 TFA has no effect on the growth of the H460-luc tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5- to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32 days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. 

分子量

2602.69

Formula

C109H151F3N34O34S2
Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6(2):178-188.

BMSpep-57

发表于由

BMSpep-57;

BMSpep-57 是一种有效的大环肽类抑制剂，抑制 PD-1/PD-L1 相互作用，IC50 为 7.68 nM。BMSpep-57 与 PD-L1 结合，MST 和 SPR 测定表明，Kd 分别为 19 nM 和 19.88 nM。BMSpep-57 通过增加 PBMC 中 IL-2 的产生促进 T 细胞功能。

BMSpep-57amp;;

BMSpep-57 Chemical Structure

CAS No. : 1629655-80-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

BMSpep-57 的其他形式现货产品:

BMSpep-57 hydrochloride

生物活性

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]
体外研究
(In Vitro)

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in  SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1868.17

Formula

C89H126N24O19S
CAS 号

1629655-80-6
Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9(1):12392.

Human PD-L1 inhibitor I

发表于由

Human PD-L1 inhibitor I;

Human PD-L1 inhibitor I 是一种 hPD-1 肽配体，KD 值为 3.39 μM。Human PD-L1 inhibitor I 可能可以干扰 hPD-L1 与 hPD-1 的结合。

Human PD-L1 inhibitor Iamp;;

Human PD-L1 inhibitor I Chemical Structure

CAS No. : 2135542-86-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor I is a hPD-1 peptide ligand, with a KD of 3.39 μM. Human PD-L1 inhibitor I may disturb the binding of hPD-L1 to hPD-1[1].

分子量

2350.58

Formula

C110H152N26O32
CAS 号

2135542-86-6
Sequence

Phe-Asn-Trp-Asp-Tyr-Ser-Trp-Lys-Ser-Glu-Arg-Leu-Lys-Glu-Ala-Tyr-Asp-Leu
Sequence Shortening

FNWDYSWKSERLKEAYDL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tianyu Wang, et al. Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway. J Med Chem. 2019 Feb 28;62(4):1715-1730.

Human PD-L1 inhibitor III

发表于由

Human PD-L1 inhibitor III;

Human PD-L1 inhibitor III 是人的 PD-L1 的抑制剂。

Human PD-L1 inhibitor IIIamp;;

Human PD-L1 inhibitor III Chemical Structure

CAS No. : 2135542-84-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Human PD-L1 inhibitor III is a human PD-L1 inhibitor.

分子量

2223.70

Formula

C97H155N29O29S1
CAS 号

2135542-84-4
Sequence Shortening

TEKDYRHGNIRMKLAYDL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

GE PD SpinTrap G-25预装脱盐柱28918004

发表于由

GE PD SpinTrap G-25预装脱盐柱28918004                                                              

PD SpinTrap G-25是一次性微量离心层析柱，用于对分子量大于5000的生物大分子纯化除杂质。为生物样品的脱盐和缓冲液置换而设计，与微量离心机配套使用。柱子预装500ul Sephadex G-25填料，柱材料为生物兼容性的聚丙烯。

1、用于对蛋白和其他大生物分子（分子量大于5000）进行小规模的除杂，可以平行操作多个样品

2、高效脱盐、缓冲液置换、除小分子化合物

3、重现性好，高通量，平行除杂处理蛋白样品

4、能制备70-130ul的样品，无稀释

基质：高度交联6%的葡聚糖。分离原理：凝胶过滤。平均颗粒大小：85-260um。排阻限度：分子量5000。样品体积：70-130ul。脱盐率：大于85%。工作PH范围：2-13.

GE PD SpinTrap G-25预装脱盐柱28918004