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8-Deoxygartanin

发表于由

天然产物 黄酮类 Flavonoids

8-Deoxygartanin 

8-Deoxygartanin 是山竹果中的一种 prenylated xanthones。8-Deoxygartanin 是一种丁基胆碱酯酶 (BChE) 的选择性抑制剂。8-Deoxygartanin 具有抗疟原虫活性，对 Plasmodium falciparum W2 植株作用的 IC50 值为 11.8 μM。8-Deoxygartanin 能抑制 NF-κB (p65) 的活化，IC50 值为 11.3 μM。

8-Deoxygartanin

8-Deoxygartanin Chemical Structure

CAS No. : 33390-41-9

规格 价格 是否有货 数量
5 mg ￥2350 In-stock
10 mg ￥4000 In-stock
50 mg   询价  
100 mg   询价  

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8-Deoxygartanin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Natural Product Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Differentiation Inducing Compound Library
  • Oxygen Sensing Compound Library
  • Phenols Library
  • Pyroptosis Compound Library
  • Flavonoids Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Antiparasitic Compound library
  • Anti-Obesity Compound Library
  • Transcription Factor Targeted Library
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生物活性

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].

IC50 & Target

p65

11.3 μM (IC50)

分子量

380.43

Formula

C23H24O5
CAS 号

33390-41-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Khaw KY, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21(11):1303-9.

    [2]. Ngouamegne ET, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar;56(3):374-7.

    [3]. Han AR, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009 Nov;72(11):2028-31.

Kushenol E

发表于由

天然产物 黄酮类 Flavonoids

Kushenol E  纯度: ≥96.0%

Kushenol E 是从 Sophora flavescens 中分离出的一类类黄酮，是 IDO1 的非竞争性抑制剂，其 IC50 值为 7.7 µM，Ki 值为 9.5 µM，具有抗肿瘤活性。

Kushenol E

Kushenol E Chemical Structure

CAS No. : 99119-72-9

规格 价格 是否有货 数量
1 mg ￥3500 In-stock
5 mg ￥10500 In-stock
10 mg   询价  
50 mg   询价  

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Kushenol E 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].

分子量

424.49

Formula

C25H28O6
CAS 号

99119-72-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488.