Arctigenin ((-)-Arctigenin) 是一种具有生物活性的木脂素,可用作抗肿瘤剂。Arctigenin 具有有效的抗氧化、抗炎和抗病毒 (influenza A virus) 活性。Arctigenin 可用于代谢紊乱和中枢神经系统功能障碍的研究。
Arctigenin Chemical Structure
CAS No. : 7770-78-7
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生物活性
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].
体外研究 (In Vitro)
Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner[1]. Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions[1]. Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells[1]. Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice[1]. Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Female SPF/VAF BALB/cAn Ncrj-nu/nu mice were injected with PANC-1 cells[1]
Dosage:
250 μg/mL, 0.2 mL
Administration:
I.p. 6 times a week for 9 weeks
Result:
Reduced the tumor weight and volume. No significant body weight loss was recognized.
Clinical Trial
分子量
372.41
Formula
C21H24O6
CAS 号
7770-78-7
中文名称
牛蒡子苷元;牛蒡苷元;牛蒡甙元
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Awale S, et, al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res. 2006 Feb 1;66(3):1751-7.
[2]. Gao Q, et, al. Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol Sin. 2018 May;39(5):787-801.
[3]. Hayashi K, et, al. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.
[4]. Wei L, et, al. Arctigenin Exerts Neuroprotective Effect by Ameliorating Cortical Activities in Experimental Autoimmune Encephalomyelitis In Vivo. Front Immunol. 2021 Jul 19;12:691590.
[5]. Maxwell T, et, al. Arctigenin inhibits the activation of the mTOR pathway, resulting in autophagic cell death and decreased ER expression in ER-positive human breast cancer cells. Int J Oncol. 2018 Apr;52(4):1339-1349.