标签归档：hng

AGA-(C8R) HNG17, humanin derivative TFA

发表于由

AGA-(C8R) HNG17, humanin derivative TFA; 纯度: 95.50%

AGA-(C8R) HNG17, humanin derivative TFA 是一种有效的人类蛋白 (HN) 的衍生物。AGA-(C8R) HNG17, humanin derivative 可完全抑制老年痴呆症相关损害引起的神经元细胞死亡。

AGA-(C8R) HNG17, humanin derivative TFAamp;;

AGA-(C8R) HNG17, humanin derivative TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥2500 In-stock
10 mg ￥4200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

AGA-(C8R) HNG17, humanin derivative TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

AGA-(C8R) HNG17, humanin derivative TFA is a potent humanin (HN) derivative. AGA-(C8R) HNG17, humanin derivative completely suppresses neuronal cell death by Alzheimer’s disease-relevant insults[1].

分子量

1850.04

Formula

C80H135F3N20O26
Sequence

Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro
Sequence Shortening

PAGASRLLLLTGEIDLP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 20 mg/mL (10.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5405 mL 2.7026 mL 5.4053 mL
5 mM 0.1081 mL 0.5405 mL 1.0811 mL
10 mM 0.0541 mL 0.2703 mL 0.5405 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Chiba T, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer’s disease-relevant insults in vitro and in vivo. J Neurosci. 2005 Nov 2;25(44):10252-61.

AGA-(C8R) HNG17, humanin derivative

发表于由

AGA-(C8R) HNG17, humanin derivative;

AGA-(C8R) HNG17, Humanin derivative 是一种有效的人类蛋白 (HN) 的衍生物。AGA-(C8R) HNG17, Humanin derivative 可完全抑制老年痴呆症相关损害引起的神经元细胞死亡。

AGA-(C8R) HNG17, humanin derivativeamp;;

AGA-(C8R) HNG17, humanin derivative Chemical Structure

CAS No. : 875910-01-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

AGA-(C8R) HNG17, humanin derivative 的其他形式现货产品:

AGA-(C8R) HNG17, humanin derivative TFA

生物活性

AGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer’s disease-relevant insults[1].

分子量

1736.02

Formula

C78H134N20O24
CAS 号

875910-01-3
Sequence Shortening

PAGASRLLLLTGEIDLP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Chiba T, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer’s disease-relevant insults in vitro and in vivo. J Neurosci. 2005 Nov 2;25(44):10252-61.