标签归档：rc

RC-3095 TFA

发表于由

RC-3095 TFA; 纯度: 97.18%

RC-3095 TFA 是一种选择性蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。RC-3095 TFA 作用于关节炎小鼠，通过减少胃氧化损伤来发挥保护作用。

RC-3095 TFAamp;;

RC-3095 TFA Chemical Structure

CAS No. : 1217463-61-0

规格 价格 是否有货 数量
1 mg ￥4400 In-stock
5 mg ￥9800 In-stock
10 mg ￥15500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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RC-3095 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist[1]. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2].

IC50 Target

Bombesin receptor; GRPR[1]
体内研究
(In Vivo)

RC-3095 impairs aversive but not recognition memory in Wistar male rats[1].
RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA)[2].
Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model[2]
Dosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies
Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies
Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA;
Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

分子量

1220.34

Formula

C58H80F3N15O11
CAS 号

1217463-61-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Roesler R, et al. RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats. Eur J Pharmacol. 2004 Feb 13;486(1):35-41.

    [2]. Oliveira PG, et al. Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis. Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis. Arthritis Rheum. 2011 Oct;63(10):2956-65.

Vapreotide acetate(Synonyms: RC-160 acetate BMY-41606 acetate)

发表于由

Vapreotide acetate;(Synonyms: RC-160 acetate; BMY-41606 acetate) 纯度: 99.67%

Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) 是 神经激肽-1 (NK1) 受体拮抗剂，其 IC50 值为 330 nM。

Vapreotide acetateamp;;(Synonyms: RC-160 acetate; BMY-41606 acetate)

Vapreotide acetate Chemical Structure

CAS No. : 849479-74-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
5 mg ￥2000 In-stock
10 mg ￥2800 In-stock
25 mg ￥5000 In-stock
50 mg ￥9000 In-stock
100 mg ￥13000 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Vapreotide acetate 相关产品

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  • FDA-Approved Drug Library Plus
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  • GPCR/G Protein Compound Library
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  • Peptidomimetic Library
  • Drug Repurposing Compound Library
  • Neurotransmitter Receptor Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Rare Diseases Drug Library
  • Peptide Library

生物活性

Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

体外研究
(In Vitro)

Vapreotide attenuates the Substance P (SP)-triggered intracellular calcium increases and NF-κB activation in a dose-dependent manner. Vapreotide also inhibits SP-induced IL-8 and MCP-1 production in HEK293-NK1R and U373MG cell lines. Vapreotide inhibits HIV-1 infection of human MDM in vitro, an effect that is reversible by SP pretreatment[1]. Vapreotide significantly inhibits GH-, PRL, and/or alpha-subunit release by human GH-secreting pituitary adenoma cells in concentrations as low as 10-12-10-14 M. Vapreotide inhibits GH release with an IC50 of 0.1 pM[2]. Vapreotide exhibits moderate-to-high affinities for SSTR2, -3, and -5 (IC50=0.17, 0.1 and 21 nM, respectively) and low affinity for SSTR1 and -4 (IC50=200 and 620 nM, respectively). RC-160 inhibits serum-induced proliferation of CHO cells expressing SSTR2 and SSTR5 (EC50=53 and 150 pM, respectively)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In cirrhosis, bleeding by rupture of oesophagogastric varices is a severe complication of portal hypertension. The acute administration of vapreotide to rats decreases collateral circulation blood flow while chronic administration attenuated its development[4]. Tumor volumes and weights are reduced by about 40% by RC-160 by s.c. injections at doses of 100 μg/day/animal. Vapreotide can inhibit the growth of androgen-independent prostate cancer when the therapy is started at an early stage of tumor development[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1191.39

Formula

C57H70N12O9S2.xC2H4O2
CAS 号

849479-74-9
中文名称

醋酸伐普肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 14.29 mg/mL (11.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8394 mL 4.1968 mL 8.3936 mL
5 mM 0.1679 mL 0.8394 mL 1.6787 mL
10 mM 0.0839 mL 0.4197 mL 0.8394 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

    [2]. Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134(1):301-6.

    [3]. Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4.

    [4]. Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48(1):154-61.

    [5]. Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.
Cell Assay
[3]

CHO cells are cultured in aMEM containing 10% FCS. After overnight attachment, the medium is changed to a MEM containing either 10% FCS or insulin with and without vapreotide. Cell growth is measured after 24 h by counting cells with a Coulter counter model ZM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4][5]

Rats: Acute effects are evaluated at baseline and 30 min after placebo or vapreotide (8 μg/kg/hr) infusions in DMNA rats. Chronic hemodynamic effects are evaluated using subcutaneous implants for five weeks in anesthetized DMNA rats and in sham rats. Hemodynamic measurements include splenorenal shunt blood flow by the transit time ultrasound method and cardiac output by the combined dilution–TTU method[4].

Mice: Nude mice bearing xenografts of the androgen-independent human prostate-cancer cell line PC-3 are treated for 4 weeks with somatostatin analog vapreotide (20 μg/day/animal), bombesin/gastrin-releasing peptide (GRP) antagonist, or the combination of both peptides. Tumor volumes and weights are measured[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

    [2]. Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134(1):301-6.

    [3]. Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4.

    [4]. Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48(1):154-61.

    [5]. Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.

RC-3095

发表于由

RC-3095;

RC-3095 是一种蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。RC-3095 作用于关节炎小鼠，通过减少胃氧化损伤来发挥保护作用。

RC-3095amp;;

RC-3095 Chemical Structure

CAS No. : 138147-78-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

RC-3095 的其他形式现货产品:

RC-3095 TFA

生物活性

RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist[1]. RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2].

IC50 Target

Bombesin receptor; GRPR[1]
体内研究
(In Vivo)

RC-3095 impairs aversive but not recognition memory in Wistar male rats[1].
RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA)[2].
Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model[2]
Dosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies
Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies
Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA;
Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

分子量

1106.32

Formula

C56H79N15O9
CAS 号

138147-78-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Roesler R, et al. RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats. Eur J Pharmacol. 2004 Feb 13;486(1):35-41.

    [2]. Oliveira PG, et al. Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis. Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis. Arthritis Rheum. 2011 Oct;63(10):2956-65.

3099756-吉威思GVS再生纤维素膜RC膜0.2um25mm

发表于由

产品型号3099756

品       牌

厂商性质代理商

产品简介
品牌 其他品牌 类型 高效
材质 其他 适用对象 水
适用范围 过滤器 用途 其他

吉威思GVS再生纤维素膜RC膜0.2um25mm，一般过滤、颗粒分离、脱溶剂、过滤需要一个强大的支撑膜。耐多种溶剂、和PH值范围在3到12的水溶液。通常用于超清洁和脱气溶剂和高效液相的流动相。的化学兼容性和耐有机溶剂。兼容几乎所有溶剂。优越的耐热性能。较低的非特殊性吸附力（牛血清蛋白）

详情介绍

吉威思GVS再生纤维素膜RC膜0.2um25mm

膜材料:
再生纤维素
膜直径 (毫米):
25 和 47
无菌:
否
消毒:
高温高压在121C，或干热在180C持续两个小时，或伽马（25千戈瑞），或ETO
zui大运行温度 (摄氏度):
134
一般应用:
水和有机溶液的过滤
分析性的样品准备、高效液相色谱法
色谱法
澄清
蛋白质化学

吉威思GVS再生纤维素膜RC膜0.2um25mm

详细应用:
一般过滤、颗粒分离、脱溶剂、过滤需要一个强大的支撑膜。耐多种溶剂、和PH值范围在3到12的水溶液。通常用于超清洁和脱气溶剂和高效液相的流动相。的化学兼容性和耐有机溶剂。兼容几乎所有溶剂。优越的耐热性能。较低的非特殊性吸附力（牛血清蛋白）

Sartorius赛多利斯再生纤维素(RC)膜

发表于由
Sartorius赛多利斯再生纤维素(RC)膜

Sartorius赛多利斯再生纤维素(RC)膜

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：Sartorius 赛多利斯
生产厂家：Sartorius赛多利斯
需求数量：

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  • 订购信息
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Sartorius赛多利斯再生纤维素(RC)膜

RC膜的特点：非特异性吸附低、耐溶剂、亲水性，主要用于为有机溶剂除颗粒过滤。直径50mm，0.45µm孔径的RC膜，与全玻璃滤器配合使用，尤其适合对HPLC的流动相进行除颗粒过滤和脱气。

 

赛多利斯

10410314-沃特曼RC58系列再生纤维素RC滤膜

发表于由
  • 型号 10410314
  • 品牌 GE whatman沃特曼
  • 【简单介绍】
    品牌 其他品牌

    沃特曼RC58系列再生纤维素RC滤膜结合了溶剂相容性、低蛋白结合、高过滤效率、优xiu的纯度等优点，提供各种孔径以满足您所有的层析样品和溶剂的制备需求。

    Whatman再生纤维素膜是由纯纤维制造而成，不含任何润湿剂和添加剂，滤膜洁净度极好，均耐受水相和有机相，无任何溶出，同时拥有极其精确的孔径与分布。Whatman再生纤维素过滤产品（包括GD/X, SPARTAN, Puradisc针式滤器）均拥有注册商标―RC。

    Whatman再生纤维素(RC)膜结合了溶剂相容性、低蛋白结合、高过滤效率、优xiu的纯度等优点，提供各种孔径以满足您所有的层析样品和溶剂的制备需求。您可以选择一种适用于多种应用的滤膜，我们的RC滤膜介质为亲水性材料，具有广泛的化学相容性，非常适合于多种溶剂的应用，包括乙腈、甲醇、****。

    特点：

    亲水性好，湿强度好，操作方便
    极好的化学耐受，适合于水和有机溶剂
    极低溶出物，相比聚合物浇铸的膜（如PVDF、混合纤维素等溶出物更少，本底更低
    超低蛋白结合，根据测算，蛋白吸附是所有过滤膜中zui低灭菌消毒含干热灭菌、紫外线、环氧乙烷等，耐受高温达180℃
    孔径范围在0.2µm-1.0µm之间

    沃特曼RC58系列再生纤维素RC滤膜  10410314
    订购信息：
     
    10410312 RC58 0.2uM 47MM 100/PK
    10410314 RC58 0.2uM 50MM 100/PK
    10410319 RC58 0.2uM 100MM 25/PK
    10410380 RC58 0.2uM 300x600MM 5/PK
    10410012 RC60 1uM 47MM 100/PK
    10410014 RC60 1uM 50MM 100/PK
    10410206 RC55 0.45uM 25MM 100/PK
    10410212 RC55 0.45uM 47MM 100/PK
    10410214 RC55 0.45uM 50MM 100/PK
    10410219 RC55 0.45uM 100MM 25/PK
    10410224 RC55 0.45uM 110MM 25/PK
    10410229 RC55 0.45uM 142MM 25/PK

RIBI-529(Synonyms: RC-529)

发表于由

生化分析试剂 Biochemical Assay Reagents
RIBI-529;(Synonyms: RC-529)

RIBI-529 (RC-529) 是一种脂质 A 模拟物 (氨基烷基氨基葡糖 4-磷酸盐)，是一种与 MPL (Corixa) 功效相似的佐剂。RIBI-529 通过 Toll 样受体 4 发出信号以刺激先天免疫系统。

RIBI-529(Synonyms: RC-529)

RIBI-529 Chemical Structure

CAS No. : 216014-46-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

RIBI-529 (RC-529), a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate), is a adjuvant with a similar efficacy to MPL (Corixa). RIBI-529 signals through Toll-like receptor 4 to stimulate the innate immune system[1].

分子量

1713.54

Formula

C98H190N3O17P
CAS 号

216014-46-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jay T Evans, et al. Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Expert Rev Vaccines. 2003 Apr;2(2):219-29.

Ginsenoside Rc(Synonyms: 人参皂苷 Rc; Panaxoside Rc)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Ginsenoside Rc;(Synonyms: 人参皂苷 Rc; Panaxoside Rc) 纯度: ge;98.0%

Ginsenoside Rc 是主要的人参皂甙之一，Ginsenoside Rc 增强 GABA 受体 A (GABAA) 介导的离子通道 (IGABA)电流。 Ginsenoside Rc 还抑制 TNF-α 和 IL-1β 表达。

Ginsenoside Rc(Synonyms: 人参皂苷 Rc; Panaxoside Rc)

Ginsenoside Rc Chemical Structure

CAS No. : 11021-14-0

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥1425 In-stock
5 mg ￥700 In-stock
10 mg ￥1200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Ginsenoside Rc 相关产品

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  • Immunology/Inflammation Compound Library
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  • Medicine Food Homology Compound Library
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  • Neurotransmitter Receptor Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Alzheimer’s Disease Compound Library
  • Neuroprotective Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Angiogenesis Related Compound Library
  • Food-Sourced Compound Library

生物活性

Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

IC50 Target[2]

TNF-α

;

IL-1β

;

体外研究
(In Vitro)

Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptorA (GABAA)-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABAA receptor[1]. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1079.27

Formula

C53H90O22
CAS 号

11021-14-0
中文名称

人参皂苷 Rc
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (46.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9266 mL 4.6328 mL 9.2655 mL
5 mM 0.1853 mL 0.9266 mL 1.8531 mL
10 mM 0.0927 mL 0.4633 mL 0.9266 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60.

    [2]. Yu T, et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133.
Kinase Assay
[2]

To evaluate the effects of Ginsenoside Rc on kinase activity, immunoprecipitated TBK1, IKKε, and p38 are incubated in reaction buffer in the presence or absence of Ginsenoside Rc. The reactions are initiated by the addition of Mg-ATP. After a 30 min incubation at 30°C, the reactions are stopped by the addition of sample buffer and the samples are boiled. Kinase activity is assessed by immunoblotting with antibodies against the phospho-forms of IKKε, IRF-3, and ATF-2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60.

    [2]. Yu T, et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133.

Malonylginsenoside Rc

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Malonylginsenoside Rc 

Malonylginsenoside Rc 是一种具有抗增殖活性的天然活性化合物。

Malonylginsenoside Rc

Malonylginsenoside Rc Chemical Structure

CAS No. : 88140-36-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Malonylginsenoside Rc is a natural active compound with anti-proliferative activity[1].

体外研究
(In Vitro)

Malonylginsenoside Rc inhibits the growth of SH-SY5Y human neuroblastoma cell line with an IC50 of 63.27 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1165.31

Formula

C56H92O25
CAS 号

88140-36-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zheng-Yi Qu, et al. New malonylginsenosides from the fresh fruits of Panax notoginseng. Fitoterapia. 2021 Apr;150:104844.

INFORSRC-306和RC-406落地式摇床

发表于由
INFORSRC-306和RC-406落地式摇床

INFORS RC－306和RC－406落地式摇床

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：INFORS
生产厂家：INFORS

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

主要特点：

其独特的设计，使其不用将摇床固定在地面，移动更方便。

技术参数：

 

型号

RC-406

振荡方式

回转式，振幅: ф50mm(ф75, 100mm可选)

振荡速度

20－400 rpm, 速度控制精度: ±1%

托盘尺寸

8个800×660（mm）

容量/托盘

96个2L摇瓶; 16个6L摇瓶

外形尺寸 / 重量

1590×916×1355（mm）/ 约470Kg

选型指南

30676: RC-406主机(振幅: ф50mm)

31223: C型，800 x 660 mm,通用振荡托板

31224: C型，800 x 660 mm,粘性振荡托板

不绣钢锥形瓶夹(25mL—2L)

塑料锥形瓶夹(100mL, 250mL, 500mL)

不绣钢Fernbach瓶夹(1.8L, 2.8L)

试管架(长度; 188mm)

塑料试管架(Ø 16 mm (15 ml); Ø 30 mm (50 ml))

63240: 粘性贴条, 200 x 200mm