标签归档：tc

oxford牛津TC50/TC4X50气体热裂解源

发表于由
oxford牛津TC50/TC4X50气体热裂解源

oxford 牛津TC50/TC4X50气体热裂解源

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：Oxford牛津
生产厂家：oxford 牛津
需求数量：

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

低气耗，低系统热载和超高效水冷

*双抗氧化灯丝适于长工时操作

*低功耗，高裂解率（ 功率60W 温度低于1000度时裂解率高于70%）
 

低气耗，低系统热载和超高效水冷

*双抗氧化灯丝适于长工时操作

*低功耗，高裂解率（ 功率60W 温度低于1000度时裂解率高于70%）
 

york约克TC200手持式温湿度计

发表于由
york约克TC200手持式温湿度计

york约克TC200手持式温湿度计

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：york约克
生产厂家：york约克

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品
特点：
□   可选探针
□   手持式
□   16组数据记录功能
□   MIN/MAX显示
□   ℃/℉可切换
 
产品说明
 
  TC200型数字温度计可以外接J,K和T型热电偶探针。人性化的设计使TC200在恶劣的环境下使用起来方便灵活。宽量程、高精度是TC200的一大优点，可存储16组温度数据，能显示最大/最小值，°C/°F自由切换，能够显示温度值的变化，这些功能使TC200成为最优秀的在线测量工具！
 
基本参数

 

参数
描述
J型热电偶量程
-200 to +1400°F (-130 to +760°C)
K型热电偶量程
-300 to +1999°F (-184 to +1093°C)
T型热电偶量程
-250 to +750°F (-157 to +399°C)
外置探头精度
±2％
外置传感器
T，J或K型热电偶

 

其它参数

 

工作环境温度
+32到 +120°F (0到 +50°C), 0 到 95% RH
电源
9V电池
电量显示
LCD显示
电池工作寿命
50个小时
显示
4位LCD显示
响应时间
10秒
认证
CE
包含附件
K型热电偶探针，9V电池
标定
标准Dickson标定证书
外形尺寸
17.8cm x 7.0cm x 3.5cm
重量
11 oz (312g)
质保
12个月

 

选件：

 

订货号
描述
N100
可追溯标定，1点
N300
可追溯标定，3点
N400
A2LA Accredited Calibration 3-pt
D617
K型热电偶，3.05米长直导线
A202
K型热电偶，30.5米长直导线
R013
可更换K型热电偶，Bead Wire Probe
D605
4英寸长刺入式探头
D608
5英寸长刺入式探头（316不锈钢）
A203
6英寸浸入式探头
A710
手提包
R007
9V电池

TC14012 TFA

发表于由

TC14012 TFA;

TC14012 TFA 是 T140 的血清稳定衍生物，是一种选择性的 CXCR4 拮抗剂，IC50 为 19.3 nM。TC14012 TFA 是有效的 CXCR7 激动剂，可将 β-arrestin2 募集到 CXCR7，EC50 为 350 nM。TC14012 TFA 具有抗 HIV 活性和抗癌活性。

TC14012 TFAamp;;

TC14012 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TC14012 TFA 的其他形式现货产品:

TC14012

生物活性

TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity[1][2].

IC50 Target[1][2]

CXCR4

19.3 nM (IC50, antagonist site)

CXCR7

350 nM (EC50, agonist site)

HIV

;

体外研究
(In Vitro)

TC14012 TFA (1 mM) inhibits more than 95% the infection of the CXCR4-expressing cells by the HXB2 (X4) or 89.6 (dual-tropic) strain whereas TC14012 TFA (1 mM) does not inhibit all the infection of the CCR5-expressing cells by the SF162 (R5) or 89.6 (dualtropic) strain[1].
TC14012 TFA leads to erk 1/2 phosphorylation in U373 cells, which express endogenous CXCR7 but not CXCR4. Upon stimulation with TC14012 TFA, CXCR7 and the CXCR7-Cter4 chimera are able to recruit arrestin, whereas CXCR4 and CXCR4-Cter7 remain silent[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2180.44

Formula

C92H141F3N34O21S2
Sequence Shortening

RR-{2Nal}-CY-{Cit}-K-{Cit}-PYR-{Cit}-CR-NH2 (Disulfide bridge:Cys4-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. H Tamamura, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1897-902.

    [2]. Stéphanie Gravel, et al. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem. 2010 Dec 3;285(49):37939-43.