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日本同仁化学SulfoBiotics- PEG-PCMal试剂货号：SB20 蛋白质巯基标记试剂| DOJINDO

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SulfoBiotics- PEG-PCMal试剂货号：SB20
蛋白质巯基标记试剂
SulfoBiotics- PEG-PCMal
商品信息
储存条件：0-5度保存
运输条件：室温
分子量：

2736.19

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硫化氢

PEG300(Synonyms: 聚乙二醇; Polyethylene glycol 300)

发表于由

生化分析试剂 Biochemical Assay Reagents
PEG300;(Synonyms: 聚乙二醇; Polyethylene glycol 300)

PEG300 (Polyethylene glycol 300)，分子量为300的中性聚合物，由乙二醇重复单元形成的水溶性、低免疫原性和生物相容性聚合物。

PEG300(Synonyms: 聚乙二醇; Polyethylene glycol 300)

PEG300 Chemical Structure

CAS No. : 25322-68-3

规格 价格 是否有货 数量
50 mL ￥350 In-stock
100 mL ￥450 In-stock
200 mL ￥765 In-stock
500 mL ; 询价 ;
1L ; 询价 ;

* Please select Quantity before adding items.

生物活性

PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1][2].

体外研究
(In Vitro)

The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

300.00

CAS 号

25322-68-3
中文名称

聚乙二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (333.33 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (166.67 mM)

* “≥” means soluble, but saturation unknown.
参考文献

  • [1]. J.Billingham, et al. Adsorption of polyamine, polyacrylic acid and polyethylene glycol on montmorillonite: An in situ study using ATR-FTIR. Volume 14, Issue 1, March 1997, Pages 19-34.

    [2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12.

    [3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21.

    [4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.

    [5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

PEG400

发表于由

生化分析试剂 Biochemical Assay Reagents
PEG400;

PEG400 是一种强亲水性聚乙二醇，可作为物质的优良溶剂。PEG400 广泛用于各种药物制剂中。

PEG400

PEG400 Chemical Structure

规格 价格 是否有货 数量
50 mL ￥350 In-stock
100 mL ￥450 In-stock
200 mL ; 询价 ;
500 mL ; 询价 ;

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生物活性

PEG400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances. PEG400 is widely used in a variety of pharmaceutical formulations.

体内研究
(In Vivo)

Treatment of Fischer 344 rats with PEG400 at a constant volume of 1.0, 2.5 or 5.0 mL/kg body weight/day 5 days/wk for 13 week does not result in any mortality attributed to chemical toxicity or changes in haematology or clinical chemistry findings[1].
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. In PEG400 based solubility-enabling formulations in oral delivery of lipophilic drugs, both the 60% and the 100% PEG-400 formulations allowed full solubilization of the dose throughout the entire gastrointestinal tract-like journey[2][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20deg;C 3 years
4deg;C 2 years
参考文献

  • [1]. Hermansky SJ, et al. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol. 1995 Feb;33(2):139-49.

    [2]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.

    [3]. Avital Beig, et al. Striking the Optimal Solubility-Permeability Balance in Oral Formulation Development for Lipophilic Drugs: Maximizing Carbamazepine Blood Levels. Mol Pharm. 2017 Jan 3;14(1):319-327.
Animal Administration
[1]

Rats[1]

Fischer-344 rats (10/group/sex) are administered polyethylene glycol 400 (PEG400) by gavage at 1.0, 2.5 or 5.0 mL/kg (1. l, 2.8 and 5.6 g/kg, respectively) body weight/day 5 days/wk for 13 wk. Animals in the control group receive water by gavage (5.0 mL/kg body weight/treatment day). An additional 10 rats/sex/group are assigned to the control and high-dose groups for a 6-wk recovery period. Evaluation of potential renal toxicity is identified as a primary objective[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Hermansky SJ, et al. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol. 1995 Feb;33(2):139-49.

    [2]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.

    [3]. Avital Beig, et al. Striking the Optimal Solubility-Permeability Balance in Oral Formulation Development for Lipophilic Drugs: Maximizing Carbamazepine Blood Levels. Mol Pharm. 2017 Jan 3;14(1):319-327.

荧光染料N-(Azido-PEG3)-N-Fluorescein-PEG3-acid

发表于由

荧光染料Dye Reagents N-(Azido-PEG3)-N-Fluorescein-PEG3-acid;

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid 是一个 PEG 类 PROTAC linker ，包含了叠氮，荧光素和羧酸基。

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid Chemical Structure

CAS No. : 2100306-50-9

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties.

IC50 Target

PEGs

;

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

811.85

Formula

C38H45N5O13S
CAS 号

2100306-50-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

荧光染料DBCO-PEG12-TCO

发表于由

荧光染料Dye Reagents DBCO-PEG12-TCO;

DBCO- PEG12-TCO 包含一个 TCO 和一个 DBCO 基团。TCO 基团可以与水合肼发生特异性反应。

DBCO-PEG12-TCO

DBCO-PEG12-TCO Chemical Structure

CAS No. : 2055022-06-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine.

体外研究
(In Vitro)

DBCO reacts with azide functionalized compounds or biomolecules without catalyst to form a stable triazole linkage, which is an ideal alternative to copper intolerant applications.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1028.23

Formula

C54H81N3O16
CAS 号

2055022-06-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

荧光染料GNF-2-PEG-acid

发表于由

荧光染料Dye Reagents GNF-2-PEG-acid;

GNF-2-PEG-acid 是GNF-2 的类似物，常被用作标记的化学或荧光探针。

GNF-2-PEG-acid

GNF-2-PEG-acid Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

GNF-2-PEG-acid, an analogue of GNF-2, is usually used as a labeled chemical or fluorescent probe.

分子量

564.51

Formula

C26H27F3N4O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Amine-PEG3-Biotin

发表于由

Amine-PEG3-Biotin; 纯度: 96.22%

Amine-PEG3-Biotin 是一种含有生物素基团和末端伯胺基的信号放大标记物。

Amine-PEG3-Biotinamp;;

Amine-PEG3-Biotin Chemical Structure

CAS No. : 359860-27-8

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥1100 In-stock
5 mg ￥1000 In-stock
10 mg ￥1400 In-stock
25 mg ￥2800 In-stock
50 mg ￥4800 In-stock
100 mg ￥8100 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Amine-PEG3-Biotin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group[1].

分子量

418.55

Formula

C18H34N4O5S
CAS 号

359860-27-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (597.30 mM; Need ultrasonic)

H2O : 100 mg/mL (238.92 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3892 mL 11.9460 mL 23.8920 mL
5 mM 0.4778 mL 2.3892 mL 4.7784 mL
10 mM 0.2389 mL 1.1946 mL 2.3892 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.33 mg/mL (5.57 mM); Clear solution

    此方案可获得 ≥ 2.33 mg/mL (5.57 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 23.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (5.57 mM); Clear solution

    此方案可获得 ≥ 2.33 mg/mL (5.57 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 23.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.33 mg/mL (5.57 mM); Clear solution

    此方案可获得 ≥ 2.33 mg/mL (5.57 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 23.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Yin H, et al. Electrochemical immunosensor for N6-methyladenosine detection in human cell lines based on biotin-streptavidin system and silver-SiO2 signal amplification. Biosens Bioelectron. 2017 Apr 15;90:494-500.

18:1 PEG-PE

发表于由

生化分析试剂 Biochemical Assay Reagents
18:1 PEG-PE;

18:1 PEG-PE 是一种聚乙二醇/磷脂酰乙醇胺偶联物，可用于药物输送。

18:1 PEG-PE

18:1 PEG-PE Chemical Structure

CAS No. : 474922-90-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

18:1 PEG-PE is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG-PE can be used for drug delivery[1].

Formula

C45H87N2O11P
CAS 号

474922-90-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. [1]Anatoly N Lukyanov, et al. Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Release. 2004 Jan 8;94(1):187-93.

CloverDirect, PEG4-AF, amber (5×300μl translation) 品牌：Protein Exp

发表于由

CloverDirect, PEG4-AF, amber (5×300μl translation)

品牌：Protein Exp
CAS No.：
储存条件：-80℃
纯度：–
产品编号

(生产商编号)

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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Hampton HR2-081-37 PEG/pH™ 2 #37 (H1) 185 ml

发表于由

上海金畔生物科技有限公司提供Hampton HR2-081-37 PEG/pH™ 2 #37 (H1) 185 ml，欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

Hampton HR2-081-37 PEG/pH™ 2 #37 (H1) 185 ml 1980.00

Hampton HR2-081-36 PEG/pH™ 2 #36 (G12) 185 ml 1980.00

Hampton HR2-081-35 PEG/pH™ 2 #35 (G11) 185 ml 1980.00

Hampton HR2-081-34 PEG/pH™ 2 #34 (G10) 185 ml 1980.00

Hampton HR2-081-33 PEG/pH™ 2 #33 (G9) 185 ml 1980.00

Hampton HR2-081-32 PEG/pH™ 2 #32 (G8) 185 ml 1980.00

Hampton HR2-081-31 PEG/pH™ 2 #31 (G7) 185 ml 1980.00

Hampton HR2-081-30 PEG/pH™ 2 #30 (G6) 185 ml 1980.00

Hampton HR2-081-29 PEG/pH™ 2 #29 (G5) 185 ml 1980.00

Hampton HR2-081-28 PEG/pH™ 2 #28 (G4) 185 ml 1980.00

Hampton HR2-081-27 PEG/pH™ 2 #27 (G3) 185 ml 1980.00

Hampton HR2-081-26 PEG/pH™ 2 #26 (G2) 185 ml 1980.00

Hampton HR2-081-25 PEG/pH™ 2 #25 (G1) 185 ml 1980.00

Hampton HR2-081-24 PEG/pH™ 2 #24 (F12) 185 ml 1980.00

Hampton HR2-081-23 PEG/pH™ 2 #23 (F11) 185 ml 1980.00

Hampton HR2-081-22 PEG/pH™ 2 #22 (F10) 185 ml 1980.00

Hampton HR2-081-21 PEG/pH™ 2 #21 (F9) 185 ml 1980.00

Hampton HR2-081-20 PEG/pH™ 2 #20 (F8) 185 ml 1980.00

Hampton HR2-081-19 PEG/pH™ 2 #19 (F7) 185 ml 1980.00

Hampton HR2-081-18 PEG/pH™ 2 #18 (F6) 185 ml 1980.00