Notoginsenoside T5

天然产物 糖类和糖苷 Saccharides and Glycosides

Notoginsenoside T5;

Notoginsenoside T5 是一种 dammarane 61 glycoside. Notoginsenoside T5 是从 P. 62 notoginseng 的根皂苷酸性脱糖基中分离出来的。

Notoginsenoside T5

Notoginsenoside T5 Chemical Structure

CAS No. : 769932-34-5

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生物活性

Notoginsenoside T5 is a dammarane 61 glycoside. Notoginsenoside T5 is isolated from the acidic deglycosylation of saponins from the roots of P. 62 notoginseng[1].

分子量

752.97

Formula

C41H68O12

CAS 号

769932-34-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang RF, et al. Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng. J Ginseng Res. 2018;42(3):270-276.

AKTide-2T TFA

AKTide-2T TFA;

AKTide-2T TFA 是一个优良的体外 AKT 底物,可竞争性抑制组蛋白 H2B 磷酸化,其 Ki 值为 12 nM。AKTide-2T TFA 模拟 Akt 的最佳磷酸化序列,是一种抑制肽,是 S22 位置中缺失了野生型 AKTide。

AKTide-2T TFAamp;;

AKTide-2T TFA Chemical Structure

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生物活性

AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

IC50 Target[1]

Akt

;

体外研究
(In Vitro)

AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1829.89

Formula

C76H115F3N28O22

Sequence

Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala

Sequence Shortening

ARKRERTYSFGHHA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15.

    [2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.

T3 Acyl glucuronide(Synonyms: T3酰基葡萄糖醛酸)

天然产物 糖类和糖苷 Saccharides and Glycosides

T3 Acyl glucuronide;(Synonyms: T3酰基葡萄糖醛酸)

T3 Acyl glucuronide 是一种内源性代谢物,是三碘甲状腺氨酸 (T3) 的酰基葡萄糖醛酸形式。

T3 Acyl glucuronide(Synonyms: T3酰基葡萄糖醛酸)

T3 Acyl glucuronide Chemical Structure

CAS No. : 910907-23-2

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生物活性

T3 Acyl glucuronide, an endogenous metabolite, is the acyl glucuronide formation of triiodothyronine (T3)[1].

IC50 Target

Endogenous metabolite[1]

体外研究
(In Vitro)

T3 Acyl glucuronide is a metabolite of T3 glucuronides after hydrolysis with β-glucuronidase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

827.10

Formula

C21H20I3NO10

CAS 号

910907-23-2

中文名称

T3酰基葡萄糖醛酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tong Z, et al. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2007 Dec;35(12):2203-10.

4422T-PALL颇尔13mm*0.45um针头过滤器

  • 型号 4422T
  • 品牌 PALL颇尔
  • 【简单介绍】

    PALL颇尔13mm*0.45um针头过滤器 4422T
    PALL聚四氟乙烯PTFE膜针头滤器13mm直径0.45um孔径货号4422 4422T,Acrodisc CR13 mm Syringe Filter。阳螺纹滑动Luer出口,3*100个/包。适用于过滤流动相,特别适用于过滤强有机溶剂。

    PALL颇尔13mm*0.45um针头过滤器 4422T

     

    PALL聚四氟乙烯PTFE膜针头滤器13mm直径0.45um孔径货号4422 4422T,Acrodisc CR13 mm Syringe Filter。阳螺纹滑动Luer出口,3*100个/包。适用于过滤流动相,特别适用于过滤强有机溶剂。

    ?6?7

    Acrodisc Syringe Filters With PTFE Membrane, 25 mmAcrodisc Syringe Filter with PTFE Membrane, 4 mmAcrodisc Syringe Filters with PTFE Membrane, 13 mmAcrodisc Syringe Filters with PTFE Membrane, 13 mmZymark* and SOTAX* Automation Certified Acrodisc PSF Syringe Filters With PTFE Membrane, 25 mmZymark and SOTAX Automation Certified Acrodisc PSF GxF Syringe Filters With PTFE Membrane, 25 mm

    PALL颇尔13mm*0.45um针头过滤器 4422T

     

TfR-T12

TfR-T12;

TfR-T12 是一个能透过血脑屏障的转铁蛋白受体 (TfR) 的结合肽,显示出 nM 水平的结合活性。

TfR-T12amp;;

TfR-T12 Chemical Structure

CAS No. : 344618-30-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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TfR-T12 的其他形式现货产品:

TfR-T12 TFA

生物活性

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

体外研究
(In Vitro)

TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1490.73

Formula

C71H99N19O15S

CAS 号

344618-30-0

Sequence

Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro

Sequence Shortening

THRPPMWSPVWP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41.

    [2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.

PR0G000T3-Merck默克密理博Progard T3纯水柱

  • 型号 PR0G000T3
  • 品牌 Merck Millipore密理博
  • 【简单介绍】
    品牌 其他品牌

    Merck默克密理博Progard T3纯水柱Progard T3(Millipore货号PR0G000T3,
    密理博货号: PR0G000T3

    纯化方式:

    活性碳

    软化水介质

    深层过滤
    Milli-Q纯水器/超纯水器/纯水机/超纯水机, Milli-QDirect一体化系统,能够直接从自来水制备III级纯水和I级超纯水。满足更高更严格的标准要求,在高/低流速情况下实现手动及定量取水

     

    Progard T3(Millipore货号PR0G000T3,
    密理博货号: PR0G000T3

    纯化方式:

    活性碳

    软化水介质

    深层过滤 
    Milli-Q纯水器/超纯水器/纯水机/超纯水机, Milli-QDirect一体化系统,能够直接从自来水制备III级纯水和I级超纯水。满足更高更严格的标准要求,在高/低流速情况下实现手动及定量取水

    Merck默克密理博Progard T3纯水柱

     

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sartorius 滤芯5181507T7–B 5181507T7–B


sartorius 滤芯5181507T7–B

sartorius 滤芯5181507T7–B Sartofluor型小型滤芯,0.2µm,0.05m2,5个/包 sartorius 滤芯5181507T7–B

sartorius滤芯5181507T7–B

   Satofluor 型小型滤芯设计为当按照GMP要求进行无菌排放的场合。内置硅胶O型圏和插口(拧口)在小型滤芯外壳和反压压力下结构稳定,保证了安全性。内插特别开发的PTFE滤膜具有极强的阻水性,其表现为非常高的水不渗透压。由于极强疏水性,采用蒸汽对Satlfluor小型滤芯消灭微生物可以在短时间内达到zui高的流速。

 技术规格

连接口: 内置硅胶O形圆和插口(拧口)

生物安全性:  通过USP CLASS VI Plastics Test

泡点(60%异丙醇): 0.1 μm  1.5bar,  0.2μm  1.0bar, 0.45μm 0.6bar

材料:聚丙烯  PTFE和硅胶

化学兼容性:  参照聚丙烯,PTFE和硅胶

过滤面积:  0.05m2,0.1m2和0.2m2

zui大压力差:  5bar(20°C),2bar(80°C)

mie jun方式:  高压mie jun (121°C或134°C)或在线蒸汽mie jun(P=0.5bar)

水渗透压:  对0.2 μm膜,4.5bar

产品外观 产品编号 产品说明
sartorius 滤芯5181507T7--B  5181507T7--B 5181558T7-B Sartofluor型小型滤芯,0.1µm,0.05m2,5个/包
5181558T8-B Sartofluor型小型滤芯,0.1µm,0.1m2,5个/包
5181558T9-B Sartofluor型小型滤芯,0.1µm,0.2m2,5个/包
5181507T7-B Sartofluor型小型滤芯,0.2µm,0.05m2,5个/包
5181507T8-B Sartofluor型小型滤芯,0.2µm,0.1m2,5个/包
5181507T9-B Sartofluor型小型滤芯,0.2µm,0.2m2,5个/包
5181407T7-B Sartofluor型小型滤芯,Junior,0.05m2,5个/包
5181506T9-B Sartofluor型小型滤芯,0.45µm,0.2m2,5个/包

荧光染料DFHBI-2T

荧光染料Dye Reagents DFHBI-2T;

DFHBI-2T 是一种可透过膜的 RNA 适配体激活的荧光探针 (ex/em=500 nm/523 nm)。DFHBI-2T 可以用于活细胞中的 RNA 成像。

DFHBI-2T

DFHBI-2T Chemical Structure

CAS No. : 1539318-40-5

规格 价格 是否有货
5 mg ¥4800 询问价格 货期
10 mg ¥8000 询问价格 货期
25 mg ¥15500 询问价格 货期

* Please select Quantity before adding items.

生物活性

DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells[1][2].

体外研究
(In Vitro)

Spinach2 imaged DFHBI-2T results in fluorescence that is detectable using the yellow emission channel[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

306.19

Formula

C12H7F5N2O2

CAS 号

1539318-40-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wenjiao Song, et al. Plug-and-play fluorophores extend the spectral properties of Spinach. J Am Chem Soc. 2014 Jan 29;136(4):1198-201.

    [2]. Robert J Trachman 3rd, et al. Structural Principles of Fluorescent RNA Aptamers. Trends Pharmacol Sci. 2017 Oct;38(10):928-939.

sartorius滤芯5181507T9-B 5181507T9-B


sartorius滤芯5181507T9-B

sartorius滤芯5181507T9-B 0.2μm 0.O5m2 sartorius滤芯5181507T9-B 5个/包

   sartorius滤芯5181507T9-B

   Satofluor 型小型滤芯设计为当按照GMP要求进行无菌排放的场合。内置硅胶O型圏和插口(拧口)在小型滤芯外壳和反压压力下结构稳定,保证了安全性。内插特别开发的PTFE滤膜具有极强的阻水性,其表现为非常高的水不渗透压。由于极强疏水性,采用蒸汽对Satlfluor小型滤芯消灭微生物可以在短时间内达到zui高的流速。

 技术规格

连接口: 内置硅胶O形圆和插口(拧口)

生物安全性:  通过USP CLASS VI Plastics Test

泡点(60%异丙醇): 0.1 μm  1.5bar,  0.2μm  1.0bar, 0.45μm 0.6bar

材料:聚丙烯  PTFE和硅胶

化学兼容性:  参照聚丙烯,PTFE和硅胶

过滤面积:  0.05m2,0.1m2和0.2m2

zui大压力差:  5bar(20°C),2bar(80°C)

mie jun方式:  高压mie jun (121°C或134°C)或在线蒸汽mie jun(P=0.5bar)

水渗透压:  对0.2 μm膜,4.5bar

DFHBI-1T

DFHBI-1T; 纯度: 98.82%

DFHBI-1T 是一种可透过膜的 RNA 适配体激活的荧光探针 (ex/em=472 nm/507 nm)。DFHBI-1T 与 RNA 适配体 (Spinach, Spinach2, iSpinach, Broccoli) 结合并产生特定的荧光和较低的背景荧光。DFHBI-1T 可以用于活细胞中的 RNA 成像。

DFHBI-1Tamp;;

DFHBI-1T Chemical Structure

CAS No. : 1539318-36-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
5 mg ¥1200 In-stock
10 mg ¥2000 In-stock
25 mg ¥4200 In-stock
50 mg ¥6500 In-stock
100 mg ¥9800 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

DFHBI-1T 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells[1][2].

体外研究
(In Vitro)

DFHBI-1T (20 μM; for 10 min) increases fluorescence in COS7 cells expressing (CGG)60-Spinach2 over DFHBI (20 μM)[1].
Broccoli-DFHBI-1T has ex/em=472 nm/507 nm and Spinach2-DFHBI-1T has ex/em=482 nm/505 nm[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

320.21

Formula

C13H9F5N2O2

CAS 号

1539318-36-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 50 mg/mL (156.15 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1230 mL 15.6148 mL 31.2295 mL
5 mM 0.6246 mL 3.1230 mL 6.2459 mL
10 mM 0.3123 mL 1.5615 mL 3.1230 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: 5.5 mg/mL (17.18 mM); Suspended solution; Need ultrasonic

    此方案可获得 5.5 mg/mL (17.18 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Wenjiao Song, et al. Plug-and-play fluorophores extend the spectral properties of Spinach. J Am Chem Soc. 2014 Jan 29;136(4):1198-201.

    [2]. Grigory S Filonov, et al. Broccoli: rapid selection of an RNA mimic of green fluorescent protein by fluorescence-based selection and directed evolution. J Am Chem Soc. 2014 Nov 19;136(46):16299-308.