标签归档：货期

N-Acetyloxytocin

发表于由

N-Acetyloxytocin;

N-Acetyloxytocin 是在大鼠垂体神经中间叶 (NIL) 中分离出来的，其存在于大鼠的几个脑区。

N-Acetyloxytocinamp;;

N-Acetyloxytocin Chemical Structure

CAS No. : 10551-48-1

规格 价格 是否有货
1 mg ￥900 询问价格 货期
5 mg ￥2800 询问价格 货期
10 mg ￥4500 询问价格 货期

* Please select Quantity before adding items.

生物活性

N-Acetyloxytocin is isolated and characterized in the neurointermediate lobe of the rat pituitary (NIL) and their presence in several brain areas of the rat[1].

体外研究
(In Vitro)

N-Acetyloxytocin is a post-translational modification of vasopressin (VP), and oxytocin (OT). The acetylated forms arc not restricted to the pineal gland, the tissue in which N-Acetyloxytocin is initially identified, but also occur in other systems producing OT and VP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1049.22

Formula

C45H68N12O13S2
CAS 号

10551-48-1
Sequence Shortening

Ac-CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu B, et al. N-acetyl-vasopressin- and N-acetyl-oxytocin-like substances: isolation and characterization in the rat neurointermediate pituitary and presence in the brain. J Neuroendocrinol. 1989;1(1):47-52.

Cortagine

发表于由

Cortagine;

Cortagine 是一种选择性的促肾上腺皮质激素释放因子受体亚型 1 (CRF1) 激动剂，对 rCRF1 的 IC50 为 2.6 nM。Cortagine 在小鼠模型中具有抗焦虑和抗抑郁作用。

Cortagineamp;;

Cortagine Chemical Structure

规格 价格 是否有货
1 mg ￥4200 询问价格 货期
5 mg ￥9500 询问价格 货期
10 mg ￥15000 询问价格 货期

* Please select Quantity before adding items.

生物活性

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model[1].

IC50 Target

IC50: 2.6 nM (rCRF1)[1]
体外研究
(In Vitro)

Cortagine inhibits rCRF1 (EC50=0.18 nM) and mCRF2β (EC50=16 nM) in transfected HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4442.06

Formula

C192H323N55O63S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hossein Tezval, et al. Cortagine, a Specific Agonist of Corticotropin-Releasing Factor Receptor Subtype 1, Is Anxiogenic and Antidepressive in the Mouse Model. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9468-73.

C-telopeptide

发表于由

C-telopeptide;

C-telopeptide 是一种 I 型胶原蛋白的交联肽，在骨吸收过程中释放，并与骨矿物质密度 (BMD) 相关。

C-telopeptideamp;;

C-telopeptide Chemical Structure

CAS No. : 162929-64-8

规格 价格 是否有货
1 mg ￥1200 询问价格 货期
5 mg ￥4800 询问价格 货期
10 mg ￥8100 询问价格 货期

* Please select Quantity before adding items.

生物活性

C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

体外研究
(In Vitro)

C-telopeptide (C-terminal telopeptide of type 1 collagen, CTx)-a marker for bone resorption. It is a peptide fragment from the carboxy terminal end of the protein matrix; used to monitor anti-resorptive therapies, such as bisphosphonates and hormone replacement therapy, in postmenopausal women and people with low bone mass (osteopenia)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

868.90

Formula

C34H56N14O13
CAS 号

162929-64-8
Sequence

Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
Sequence Shortening

EKAHDGGR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Bradykinin (1-3)

发表于由

Bradykinin (1-3);

Bradykinin (1-3) 是一个含 3个氨基酸的残基肽。Bradykinin (1-3) 是由脯氨酰内肽酶切割形成的一种氨基截短的激肽肽。

Bradykinin (1-3)amp;;

Bradykinin (1-3) Chemical Structure

CAS No. : 23815-91-0

规格 价格 是否有货
5 mg ￥900 询问价格 货期
10 mg ￥1200 询问价格 货期
25 mg ￥2400 询问价格 货期

* Please select Quantity before adding items.

生物活性

Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

分子量

368.43

Formula

C16H28N6O4
CAS 号

23815-91-0
Sequence

Arg-Pro-Pro
Sequence Shortening

RPP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Asp-Asp-Asp-Asp-Asp

发表于由

Asp-Asp-Asp-Asp-Asp;

Asp-Asp-Asp-Asp-Asp 是由 5 个天冬氨酸残基组成的多肽。

Asp-Asp-Asp-Asp-Aspamp;;

Asp-Asp-Asp-Asp-Asp Chemical Structure

CAS No. : 124219-00-7

规格 价格 是否有货
1 mg ￥500 询问价格 货期
5 mg ￥1000 询问价格 货期
10 mg ￥1400 询问价格 货期

* Please select Quantity before adding items.

生物活性

Asp-Asp-Asp-Asp-Asp is a peptide consists of 5 Asp.

分子量

593.45

Formula

C20H27N5O16
CAS 号

124219-00-7
Sequence

Asp-Asp-Asp-Asp-Asp
Sequence Shortening

DDDDD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Speract(Synonyms: 精子活化肽)

发表于由

Speract;(Synonyms: 精子活化肽)

Speract 是一种调节精子活力的海胆蛋肽，也刺激精子线粒体代谢。

Speractamp;;(Synonyms: 精子活化肽)

Speract Chemical Structure

CAS No. : 76901-59-2

规格 价格 是否有货
1 mg ￥700 询问价格 货期
5 mg ￥2800 询问价格 货期
10 mg ￥4900 询问价格 货期

* Please select Quantity before adding items.

生物活性

Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.

体外研究
(In Vitro)

Speract is a decapeptide from the outer jelly layer of theStrongylocentrotus purpuratus egg that upon binding to its receptor in the sperm, stimulates sperm motility, respiration and ion fluxes, among other physiological events. Speract increases NADH levels and depolarizes the sea urchin sperm mitochondrion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

891.92

Formula

C38H57N11O14
CAS 号

76901-59-2
Sequence

Gly-Phe-Asp-Leu-Asn-Gly-Gly-Gly-Val-Gly
Sequence Shortening

GFDLNGGGVG
中文名称

精子活化肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. García-Rincón J, et al. Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. Biochim Biophys Acta. 2016 Apr;1857(4):415-26.

Exendin-3

发表于由

Exendin-3;

Exendin-3是从蜥蜴 Heloderma horridurn 毒液分离的生物活性肽。

Exendin-3amp;;

Exendin-3 Chemical Structure

CAS No. : 130357-25-4

规格 价格 是否有货
500 μg ￥2200 询问价格 货期
1 mg ￥3200 询问价格 货期
5 mg ￥9900 询问价格 货期

* Please select Quantity before adding items.

生物活性

Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.

IC50 Target

VIP receptor, putative exendin receptor[1]
体外研究
(In Vitro)

Exendin-3 interacts with at least two receptors on guinea pig pancreatic acini; at high concentrations (>100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release; at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4202.57

Formula

C184H282N50O61S
CAS 号

130357-25-4
Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15;266(5):2897-902.
Kinase Assay
[1]

Effect of increasing concentrations of two VIP receptor antagonists on the increase in amylase release are observed with VIP, secretin, or exendin-3. Male Hartley guinea pigs Acini were incubated with VIP (1 nM), secretin (1 μM), or Exendin-3 (1 μM) for 30 min at 37°C, alone or in combination with indicated concentrations of [AcTyr, D-Phe]GRF 1-29 amide (solid symbols) or [4-Cl-D-Phe,Leu] VIP (open symbols)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15;266(5):2897-902.

TAT 2-4

发表于由

TAT 2-4;

TAT 2-4 是一种多肽，来源于 HIV-1 反式激活因子 (Tat)。

TAT 2-4amp;;

TAT 2-4 Chemical Structure

CAS No. : 1159916-66-1

规格 价格 是否有货
1 mg ￥900 询问价格 货期
5 mg ￥2200 询问价格 货期
10 mg ￥3500 询问价格 货期

* Please select Quantity before adding items.

生物活性

TAT 2-4 is a peptide derived from HIV-1 transactivator of transcription (Tat) protein.

分子量

3215.74

Formula

C132H240N66O29
CAS 号

1159916-66-1
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly
Sequence Shortening

YGRKKRRQRRRGYGRKKRRQRRRG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Kassinin(Synonyms: 肛褶蛙肽)

发表于由

Kassinin;(Synonyms: 肛褶蛙肽)

Kassinin 是一种衍生自 Kassina 蛙的肽。Kassinin属于速激肽家族的神经肽。Kassinin分泌作为防御信号，并参与神经肽信号传导。

Kassininamp;;(Synonyms: 肛褶蛙肽)

Kassinin Chemical Structure

CAS No. : 63968-82-1

规格 价格 是否有货
1 mg ￥770 询问价格 货期
5 mg ￥2300 询问价格 货期
10 mg ￥3850 询问价格 货期
25 mg ￥8200 询问价格 货期

* Please select Quantity before adding items.

生物活性

Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

体外研究
(In Vitro)

Amino acid composition and sequence of Kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis. Methanol extracts of the skin of the African amphibian Kassina senegalensis contain a dodecapeptide, Kassinin, belonging to the family of tachykinins or physalaemin-like peptides. Kassinin, like all other natural tachykinins, possesses the characteristic C-terminal tripeptide Gly-Leu-Met-NH2 and a phenylalanine residue in position 5 from the C-terminus. The amino acid sequence in the N-moiety of the molecule differs sharply from that of the other tachykinins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1334.54

Formula

C59H95N15O18S
CAS 号

63968-82-1
Sequence

Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

DVPKSDQFVGLM-NH2
中文名称

肛褶蛙肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anastasi A, et al. Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis. Experientia. 1977 Jul 15;33(7):857-8.

Ceratotoxin A

发表于由

Ceratotoxin A;

Ceratotoxin A 是由 29 个氨基酸组成的多肽，从副腺分泌液中分离到，具有抗细菌 (anti-bacterial) 的作用。

Ceratotoxin Aamp;;

Ceratotoxin A Chemical Structure

CAS No. : 150671-04-8

规格 价格 是否有货
1 mg ￥1100 询问价格 货期
5 mg ￥3500 询问价格 货期
10 mg ￥5500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Ceratotoxin A, a 29-residue peptide isolated from the accessory gland secretion fluid, with strong anti-bacterial activity.

IC50 Target

Bacterial[1]
体外研究
(In Vitro)

Ceratotoxin A is a 29-residue peptide isolated from the accessory gland secretion fluid, shows anti-E.coli activity, and is heat stable[1]. Ceratotoxin A is effective against Escherichia coli ATCC 23739, Pseudomonas aeruginos ATCC 27853, and Bacillus subtilis ATCC 6633 with minimal inhibitory concentration (MIC) of 7, 7, and 3.5 µM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2868.59

Formula

C135H243N35O32
CAS 号

150671-04-8
Sequence

Ser-Ile-Gly-Ser-Ala-Leu-Lys-Lys-Ala-Leu-Pro-Val-Ala-Lys-Lys-Ile-Gly-Lys-Ile-Ala-Leu-Pro-Ile-Ala-Lys-Ala-Ala-Leu-Pro
Sequence Shortening

SIGSALKKALPVAKKIGKIALPIAKAALP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Marchini D, et al. Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera). Insect Biochem Mol Biol. 1993 Jul;23(5):591-8.

    [2]. Marri L, et al. The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12. Curr Microbiol. 1996 Jul;33(1):40-3.