GRGDSPK;(Synonyms: EMD 56574) 纯度: 98.30%
GRGDSPK (EMD 56574) 是包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽。 GRGDSPK 是一种竞争性且可逆的抑制肽,可抑制整联蛋白-纤连蛋白结合。GRGDSPK 可以用于研究整联蛋白在骨形成和吸收中的作用。
GRGDSPK Chemical Structure
CAS No. : 111119-28-9
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3800 | In-stock | |
10 mg | ¥6800 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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GRGDSPK 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2]. |
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体外研究 (In Vitro) |
GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner as determined by measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
715.76 |
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Formula |
C28H49N11O11 |
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CAS 号 |
111119-28-9 |
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Sequence |
Gly-Arg-Gly-Asp-Ser-Pro-Lys |
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Sequence Shortening |
GRGDSPK |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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Cell Assay [1] |
Proliferation assays are carried out in 48-well cell culture dishes coated with OCP or HL. In proliferation assays, 7.25×103 cells in 0.5 mL of culture medium are seeded in a 48-well dish. Culture medium is changed every 3 days. After 1, 6, 12, and 18 days of culture, plates are washed thrice with PBS to remove unattached cells, and attached cells are collected by trypsinization. The number of cells is counted using a hemocytometer. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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