Gymnoside III(Synonyms: 手参苷III)

天然产物 糖类和糖苷 Saccharides and Glycosides

Gymnoside III;(Synonyms: 手参苷III)

Gymnoside III 是一种从 Gymnadenia conopsea 的块茎中分离出来的 2-异丁基苹果酸葡糖氧基氧基苄酯。

Gymnoside III(Synonyms: 手参苷III)

Gymnoside III Chemical Structure

CAS No. : 899430-03-6

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生物活性

Gymnoside III is a glucosyloxybenzyl 2-isobutylmalate isolated from the tubers of Gymnadenia conopsea[1].

分子量

930.90

Formula

C42H58O23

CAS 号

899430-03-6

中文名称

手参苷III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Toshio Morikawa, et al. Glucosyloxybenzyl 2-Isobutylmalates from the tubers of Gymnadenia conopsea. J Nat Prod. 2006 Jun;69(6):881-6.

Mogroside III A2(Synonyms: 罗汉果苷IIIA2)

天然产物 糖类和糖苷 Saccharides and Glycosides

Mogroside III A2;(Synonyms: 罗汉果苷IIIA2)

Mogroside III A2 是一种葫芦素糖苷。Mogroside III A2 可以抑制 Epstein-Barr 病毒早期抗原 (EBV-EA) 的激活。Mogroside III A2 对 NOR 1 的激活有弱的抑制作用。

Mogroside III A2(Synonyms: 罗汉果苷IIIA2)

Mogroside III A2 Chemical Structure

CAS No. : 88901-43-3

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生物活性

Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1[1].

IC50 Target

Epstein-Barr virus[1]

体外研究
(In Vitro)

Mogroside III A2 inhibits the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with IC50 of 352 mol ratio/32 pmol TPA[1].
Mogroside III A2 shows weak inhibitory effects on activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

963.15

Formula

C48H82O19

CAS 号

88901-43-3

中文名称

罗汉果苷IIIA2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Akihisa T, et, al. Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2007 May;70(5):783-8.

Picroside III(Synonyms: 胡黄连苷III)

天然产物 糖类和糖苷 Saccharides and Glycosides

Picroside III;(Synonyms: 胡黄连苷III)

Picroside III 胡黄连苷 III 是一种从传统中药胡黄连 (Picrorhiza scrophulariiflora,PS) 中分离出的环烯醚萜苷。

Picroside III(Synonyms: 胡黄连苷III)

Picroside III Chemical Structure

CAS No. : 64461-95-6

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生物活性

Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine[1].

分子量

538.50

Formula

C25H30O13

CAS 号

64461-95-6

中文名称

胡黄连苷III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhu J, et al. A pre-clinical pharmacokinetic study in rats of three naturally occurring iridoid glycosides, Picroside-I, II and III, using a validated simultaneous HPLC-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 1;993-994:47-59.

Crocin III(Synonyms: 西红花苷 III)

天然产物 糖类和糖苷 Saccharides and Glycosides

Crocin III;(Synonyms: 西红花苷 III)

Crocin III 是一种藏红花素,来自藏红花 (Crocus sutivus L.)。Crocins 可以抑制肿瘤细胞的细胞生长,并具有抗炎活性。Crocins 用作香料和着色剂。

Crocin III(Synonyms: 西红花苷 III)

Crocin III Chemical Structure

CAS No. : 55750-85-1

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Crocin III 相关产品

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生物活性

Crocin III is a crocetin from saffron (Crocus sutivus L.). Crocetins inhibit cell growth of tumor cells and has anti-inflammatory activity. Crocins serve as spices and coloring agents[1][2][3].

分子量

652.68

Formula

C32H44O14

CAS 号

55750-85-1

中文名称

西红花苷 III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Xiangdong Pu, et al. In Vivo Production of Five Crocins in the Engineered Escherichia coli. ACS Synth Biol. 2020 May 15;9(5):1160-1168.

    [2]. J Escribano, et al. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 1996 Feb 27;100(1-2):23-30.

    [3]. Yaya Hu, et al. Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund’s complete adjuvant-induced arthritis in rats. Phytomedicine. 2019 Feb;53:223-233.

Beauveriolide III

Beauveriolide III;

Beauveriolide III 是小鼠巨噬细胞中脂滴形成的抑制剂。

Beauveriolide IIIamp;;

Beauveriolide III Chemical Structure

CAS No. : 221111-70-2

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生物活性

Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages[1].

分子量

487.63

Formula

C27H41N3O5

CAS 号

221111-70-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. ICHIJI NAMATAME, et al. Structure Elucidation of Fungal Beauveriolide III, a Novel Inhibitor of Lipid Droplet Formation in Mouse Macrophages.

Urocortin III, mouse

Urocortin III, mouse;

Urocortin III, mouse 是促肾上腺皮质激素释放因子 (CRF) 的相关肽。Urocortin III 优先结合并激活 CRF-R2。Urocortin III (Ucn3) 是行为压力反应体系的一种的已知组分。Urocortin III 和 CRF-R2 存在于大脑杏仁核中,可调节复杂的社会动力学行为。

Urocortin III, mouseamp;;

Urocortin III, mouse Chemical Structure

CAS No. : 357952-10-4

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Urocortin III, mouse 的其他形式现货产品:

Urocortin III, mouse TFA

生物活性

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2[1]. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics[2].

分子量

4172.97

Formula

C186H312N52O52S2

CAS 号

357952-10-4

Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Ile-Leu-Phe-Asn-Ile-Asp-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Lys-Ala-Ala-Ala-Asn-Ala-Gln-Leu-Met-Ala-Gln-Ile-NH2

Sequence Shortening

FTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. Lewis K, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

    [2]. Shemesh Y, et al. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat Neurosci. 2016 Nov;19(11):1489-1496.

Astragaloside III(Synonyms: 黄芪皂苷 III)

天然产物 糖类和糖苷 Saccharides and Glycosides

Astragaloside III (Synonyms: 黄芪皂苷 III) 纯度: 98.89%

黄芪皂苷III (Astragaloside III)是从黄芪中分离到的一种天然产物。

Astragaloside III(Synonyms: 黄芪皂苷 III)

Astragaloside III Chemical Structure

CAS No. : 84687-42-3

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Astragaloside III 相关产品

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生物活性

Astragaloside III is a natural product isolated from Astragalus.

分子量

784.97

Formula

C41H68O14

CAS 号

84687-42-3

中文名称

黄芪皂苷 III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (63.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2739 mL 6.3697 mL 12.7393 mL
5 mM 0.2548 mL 1.2739 mL 2.5479 mL
10 mM 0.1274 mL 0.6370 mL 1.2739 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.18 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (3.18 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. SHI Jing-chao, et al. Determination of Astragaloside III and Astragaloside IV in Astragalus with HPLC-ELSD Method. World Journal of Integrated Traditional and Western Medicine, 2014-07

Mogroside III-E(Synonyms: 罗汉果苷 III-E;罗汉果甜苷 III-E;罗汉果甙 III-E;罗汉果甜甙 III-E)

天然产物 糖类和糖苷 Saccharides and Glycosides

Mogroside III-E (Synonyms: 罗汉果苷 III-E;罗汉果甜苷 III-E;罗汉果甙 III-E;罗汉果甜甙 III-E) 纯度: 98.02%

Mogroside III-E 是从罗汉果中分离得到的葫芦烷型化合物,可抑制 NO 的释放,具有抗肺纤维化作用。

Mogroside III-E(Synonyms: 罗汉果苷 III-E;罗汉果甜苷 III-E;罗汉果甙 III-E;罗汉果甜甙 III-E)

Mogroside III-E Chemical Structure

CAS No. : 88901-37-5

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5 mg ¥2020 In-stock
10 mg ¥3430 In-stock
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Mogroside III-E 相关产品

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生物活性

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, inhibits NO release, with anti-fibrotic activity[1].

分子量

963.15

Formula

C48H82O19

CAS 号

88901-37-5

中文名称

罗汉果苷 III-E;罗汉果甜苷 III-E;罗汉果甙 III-E;罗汉果甜甙 III-E

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (103.83 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0383 mL 5.1913 mL 10.3826 mL
5 mM 0.2077 mL 1.0383 mL 2.0765 mL
10 mM 0.1038 mL 0.5191 mL 1.0383 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Tao L, et al. Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways. J Pharmacol Exp Ther. 2017 May;361(2):268-279.

Atractylenolide III(Synonyms: ICodonolactone; 8β-Hydroxyasterolide)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Atractylenolide III (Synonyms: ICodonolactone; 8β-Hydroxyasterolide) 纯度: 99.91%

白术内酯III(Atractylenolide-III)是白术根茎主要成分,有诱导肺癌细胞凋亡活性。

Atractylenolide III(Synonyms: ICodonolactone;  8β-Hydroxyasterolide)

Atractylenolide III Chemical Structure

CAS No. : 73030-71-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2035 In-stock
10 mg ¥1850 In-stock
50 mg ¥5400 In-stock
100 mg   询价  
200 mg   询价  

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Atractylenolide III 相关产品

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  • Traditional Chinese Medicine Monomer Library

生物活性

Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells. IC50 value: Target: Anticancer natural compound in vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3]. in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2].

分子量

248.32

Formula

C15H20O3

CAS 号

73030-71-4

中文名称

白术内酯 III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (201.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Kang TH, et al. Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9.

    [2]. Wang KT, et al. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8.

    [3]. Kim HK, et al. Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31.

10-Deacetylbaccatin III(Synonyms: 10-脱乙酰巴卡丁 III)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

10-Deacetylbaccatin III (Synonyms: 10-脱乙酰巴卡丁 III) 纯度: 99.33%

10-Deacetylbaccatin-III是紫杉醇制备过程中的中间体。

10-Deacetylbaccatin III(Synonyms: 10-脱乙酰巴卡丁 III)

10-Deacetylbaccatin III Chemical Structure

CAS No. : 32981-86-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥635 In-stock
100 mg ¥577 In-stock
200 mg ¥1023 In-stock
500 mg ¥2213 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

10-Deacetylbaccatin III 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library

生物活性

10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value: Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate.

分子量

544.59

Formula

C29H36O10

CAS 号

32981-86-5

中文名称

10-脱乙酰巴卡丁 III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (91.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8362 mL 9.1812 mL 18.3624 mL
5 mM 0.3672 mL 1.8362 mL 3.6725 mL
10 mM 0.1836 mL 0.9181 mL 1.8362 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26.

    [2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.

    [3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6.

    [4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97(25):13591-13596.