标签归档：iii

Beauveriolide III

发表于由

Beauveriolide III;

Beauveriolide III 是小鼠巨噬细胞中脂滴形成的抑制剂。

Beauveriolide IIIamp;;

Beauveriolide III Chemical Structure

CAS No. : 221111-70-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages[1].

分子量

487.63

Formula

C27H41N3O5
CAS 号

221111-70-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. ICHIJI NAMATAME, et al. Structure Elucidation of Fungal Beauveriolide III, a Novel Inhibitor of Lipid Droplet Formation in Mouse Macrophages.

Urocortin III, mouse

发表于由

Urocortin III, mouse;

Urocortin III, mouse 是促肾上腺皮质激素释放因子 (CRF) 的相关肽。Urocortin III 优先结合并激活 CRF-R2。Urocortin III (Ucn3) 是行为压力反应体系的一种的已知组分。Urocortin III 和 CRF-R2 存在于大脑杏仁核中，可调节复杂的社会动力学行为。

Urocortin III, mouseamp;;

Urocortin III, mouse Chemical Structure

CAS No. : 357952-10-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Urocortin III, mouse 的其他形式现货产品:

Urocortin III, mouse TFA

生物活性

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2[1]. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics[2].

分子量

4172.97

Formula

C186H312N52O52S2
CAS 号

357952-10-4
Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Ile-Leu-Phe-Asn-Ile-Asp-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Lys-Ala-Ala-Ala-Asn-Ala-Gln-Leu-Met-Ala-Gln-Ile-NH2
Sequence Shortening

FTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. Lewis K, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

    [2]. Shemesh Y, et al. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat Neurosci. 2016 Nov;19(11):1489-1496.

日本同仁化学Hampton蛋白结晶试剂盒Iron(III) chloride hexahydrate/HR2-717| DOJINDO

发表于由

上海金畔生物科技有限公司代理日本同仁化学 DOJINDO代理商全线产品，欢迎访问官网了解更多信息

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Products > Optimize Reagents > Optimize – Salts > Iron(III) chloride hexahydrate

Iron(III) chloride hexahydrate

Hampton蛋白结晶试剂盒Iron(III) chloride hexahydrate/HR2-717

CAT NO

HR2-717

NAME

1.0 M Iron(III) chloride hexahydrate

DESCRIPTION

100 mL

PRICE

$79.00

支持材料

Hampton蛋白结晶试剂盒Iron(III) chloride hexahydrate/HR2-717 HR2-717 Iron(III) chloride hexahydrate SDS

应用

  • Crystallization grade Iron(III) chloride hexahydrate for formulating screens or for optimization
  • 结晶级氯化铁 (III) 六水合物，用于筛选或优化

特征

  • Sterile filtered solution
  • Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
  • 无菌过滤溶液
    在 1+ 型超纯水中配制：25°C 时电阻率为 18.2 兆欧厘米，总有机碳 < 5 ppb，无细菌（<1 细菌 (CFU/ml)），无热原（<0.03 内毒素 (EU/ml)） , 无 RNase (< 0.01 ng/mL) 和无 DNase (< 4 pg/µL)

描述Iron(III) chloride hexahydrate

Synonyms: Ferric chloride hexahydrate
FeCl3 • 6H20
Mr 270.29
CAS Number [10025-77-1]
EC Number 231-729-4
RTECS NO5425000
Merck 14,4019
MDL Number MFCD00149712
PubChem Substance ID 24868480
UN Number 3260 8/PG 3
Purity 98 – 102%

Measured pH range: 0.6 – 1.0 at 25°C
Measured Conductivity Range: 90.0 – 97.8 mS/cm at 25°C

别名：六水氯化铁
FeCl3 • 6H20
270.29 先生
CAS 编号 [10025-77-1]
欧盟编号 231-729-4
RTECS NO5425000
默克 14,4019
MDL 编号 MFCD00149712
PubChem 物质 ID 24868480
联合国编号 3260 8/PG 3
纯度 98 – 102%

测量的 pH 值范围：25°C 时 0.6 – 1.0
测量的电导率范围：25°C 时 90.0 – 97.8 mS/cm

As ≤0.0005%
Ca ≤0.0005%
Cd ≤0.001%
Cl ≤0.002%
Co ≤0.005%
Cr ≤0.01%
Cu ≤0.002%
Fe2+ ≤0.002%
K   ≤0.005%
Mg ≤0.001%
Mn ≤0.1%
N   ≤0.001%
Na ≤0.01%
Ni  ≤0.005%
NO3 ≤0.01%
Pb  ≤0.002%
PO4 ≤0.01%
SO4 ≤0.005%
Zn  ≤0.002%

Iron(III) chloride hexahydrate

Astragaloside III(Synonyms: 黄芪皂苷 III)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Astragaloside III (Synonyms: 黄芪皂苷 III) 纯度: 98.89%

黄芪皂苷III (Astragaloside III)是从黄芪中分离到的一种天然产物。

Astragaloside III(Synonyms: 黄芪皂苷 III)

Astragaloside III Chemical Structure

CAS No. : 84687-42-3

规格 价格 是否有货 数量
5 mg ￥2500 In-stock
10 mg ￥4200 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Astragaloside III 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Astragaloside III is a natural product isolated from Astragalus.

分子量

784.97

Formula

C41H68O14
CAS 号

84687-42-3
中文名称

黄芪皂苷 III
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (63.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2739 mL 6.3697 mL 12.7393 mL
5 mM 0.2548 mL 1.2739 mL 2.5479 mL
10 mM 0.1274 mL 0.6370 mL 1.2739 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.18 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (3.18 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. SHI Jing-chao, et al. Determination of Astragaloside III and Astragaloside IV in Astragalus with HPLC-ELSD Method. World Journal of Integrated Traditional and Western Medicine, 2014-07

Mogroside III-E(Synonyms: 罗汉果苷 III-E；罗汉果甜苷 III-E；罗汉果甙 III-E；罗汉果甜甙 III-E)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Mogroside III-E (Synonyms: 罗汉果苷 III-E；罗汉果甜苷 III-E；罗汉果甙 III-E；罗汉果甜甙 III-E) 纯度: 98.02%

Mogroside III-E 是从罗汉果中分离得到的葫芦烷型化合物，可抑制 NO 的释放，具有抗肺纤维化作用。

Mogroside III-E(Synonyms: 罗汉果苷 III-E；罗汉果甜苷 III-E；罗汉果甙 III-E；罗汉果甜甙 III-E)

Mogroside III-E Chemical Structure

CAS No. : 88901-37-5

规格 价格 是否有货 数量
5 mg ￥2020 In-stock
10 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Mogroside III-E 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library

生物活性

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, inhibits NO release, with anti-fibrotic activity[1].

分子量

963.15

Formula

C48H82O19
CAS 号

88901-37-5
中文名称

罗汉果苷 III-E；罗汉果甜苷 III-E；罗汉果甙 III-E；罗汉果甜甙 III-E
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (103.83 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0383 mL 5.1913 mL 10.3826 mL
5 mM 0.2077 mL 1.0383 mL 2.0765 mL
10 mM 0.1038 mL 0.5191 mL 1.0383 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.60 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Tao L, et al. Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways. J Pharmacol Exp Ther. 2017 May;361(2):268-279.

Atractylenolide III(Synonyms: ICodonolactone; 8β-Hydroxyasterolide)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Atractylenolide III (Synonyms: ICodonolactone; 8β-Hydroxyasterolide) 纯度: 99.91%

白术内酯III(Atractylenolide-III)是白术根茎主要成分，有诱导肺癌细胞凋亡活性。

Atractylenolide III(Synonyms: ICodonolactone; 8β-Hydroxyasterolide)

Atractylenolide III Chemical Structure

CAS No. : 73030-71-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥2035 In-stock
10 mg ￥1850 In-stock
50 mg ￥5400 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Atractylenolide III 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells. IC50 value: Target: Anticancer natural compound in vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3]. in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2].

分子量

248.32

Formula

C15H20O3
CAS 号

73030-71-4
中文名称

白术内酯 III
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (201.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Kang TH, et al. Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9.

    [2]. Wang KT, et al. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8.

    [3]. Kim HK, et al. Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31.

10-Deacetylbaccatin III(Synonyms: 10-脱乙酰巴卡丁 III)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

10-Deacetylbaccatin III (Synonyms: 10-脱乙酰巴卡丁 III) 纯度: 99.33%

10-Deacetylbaccatin-III是紫杉醇制备过程中的中间体。

10-Deacetylbaccatin III(Synonyms: 10-脱乙酰巴卡丁 III)

10-Deacetylbaccatin III Chemical Structure

CAS No. : 32981-86-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥635 In-stock
100 mg ￥577 In-stock
200 mg ￥1023 In-stock
500 mg ￥2213 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

10-Deacetylbaccatin III 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
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  • Terpenoids Library
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  • FDA Approved & Pharmacopeial Drug Library

生物活性

10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value: Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate.

分子量

544.59

Formula

C29H36O10
CAS 号

32981-86-5
中文名称

10-脱乙酰巴卡丁 III
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (91.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8362 mL 9.1812 mL 18.3624 mL
5 mM 0.3672 mL 1.8362 mL 3.6725 mL
10 mM 0.1836 mL 0.9181 mL 1.8362 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26.

    [2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.

    [3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6.

    [4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97（25）：13591-13596.

Viscumneoside III(Synonyms: 槲寄生新苷III)

发表于由

天然产物 黄酮类 Flavonoids

Viscumneoside III (Synonyms: 槲寄生新苷III)

Viscumneoside III 是一种二氢黄酮 O-糖苷，抑制酪氨酸酶 (tyrosinase)，IC50 为 0.5 mM。Viscumneoside III 具有抗心绞痛作用。

Viscumneoside III(Synonyms: 槲寄生新苷III)

Viscumneoside III Chemical Structure

CAS No. : 118985-27-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC50 of 0.5 mM. Viscumneoside III has anti-angina pectoris[1].

体外研究
(In Vitro)

Viscumneoside III (1.0 mg/mL) has the inhibition activitie on tyrosinase of 77% . Viscumneoside III is used as a material for cosmetics with whitening function[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

596.53

Formula

C27H32O15
CAS 号

118985-27-6
中文名称

槲寄生新苷III
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. LeiZou, et al. Total synthesis of viscumneoside III of Viscum coloratum. Tetrahedron,Volume 74, Issue 19, 10 May 2018,Pages 2376-2382.

    [2]. Se-Hui Jung, et al. Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis. Molecules. 2019 Jul 12;24(14):2549.

Dioscin(Synonyms: 薯蓣皂甙; Collettiside III; CCRIS 4123)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Dioscin;(Synonyms: 薯蓣皂甙; Collettiside III; CCRIS 4123) 纯度: 99.76%

Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷，针对多种癌细胞有较好的抗癌活性。

Dioscin(Synonyms: 薯蓣皂甙; Collettiside III; CCRIS 4123)

Dioscin Chemical Structure

CAS No. : 19057-60-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥612 In-stock
5 mg ￥400 In-stock
10 mg ￥640 In-stock
50 mg ￥2200 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

Dioscin 相关产品

bull;相关化合物库:

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  • FDA Approved amp; Pharmacopeial Drug Library
  • Food-Sourced Compound Library

生物活性

Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. IC50 value: Target: Anticancer agent in vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was an important mechanism by which dioscin inhibited cancer [1]. dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity. Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model [2]. Dioscin reduced cell death and lactate dehydrogenase (LDH) release in cells subjected to I/R. I/R induced apoptosis and cytochrome c release from mitochondria to the cytosol and this was prevented by dioscin. In support, dioscin decreased Bax but increased Bcl-2 mRNA expression. Dioscin prevented I/R induced dissipation of ΔΨm [3].

分子量

869.04

Formula

C45H72O16
CAS 号

19057-60-4
中文名称

薯蓣皂甙；薯蓣皂甙
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL (115.07 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1507 mL 5.7535 mL 11.5070 mL
5 mM 0.2301 mL 1.1507 mL 2.3014 mL
10 mM 0.1151 mL 0.5753 mL 1.1507 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    此方案可获得 ≥ 2.25 mg/mL (2.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 22.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    此方案可获得 ≥ 2.25 mg/mL (2.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 22.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    此方案可获得 ≥ 2.25 mg/mL (2.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 22.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.

    [2]. Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.

    [3]. Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.

荧光染料Sudan III(Synonyms: 苏丹红Ⅲ Sudan Red III Tetrazobenzene-β-naphthol 111440 Red)

发表于由

荧光染料Dye Reagents Sudan III;(Synonyms: 苏丹红Ⅲ; Sudan Red III; Tetrazobenzene-β-naphthol; 111440 Red) 纯度: 85.0%

Sudan III 是一种疏水性双偶氮染料。

Sudan IIIamp;;(Synonyms: 苏丹红Ⅲ; Sudan Red III; Tetrazobenzene-β-naphthol; 111440 Red)

Sudan III Chemical Structure

CAS No. : 85-86-9

规格 价格 是否有货 数量
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

Sudan III 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Peptidomimetic Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Microbial Metabolite Library

生物活性

Sudan III is a hydrophobic bisazo dye[1].

体外研究
(In Vitro)

Sudan III changes its color from orange to blue against a small volume of sulfuric acid, and the acetonitrile solution of Sudan III is the most suitable for observing the color-change phenomenon. H-NMR and UV-Vis spectroscopic studies show that the color-change mechanism of Sudan III against sulfuric acid is due to the protonation of the dye by sulfuric acid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

352.39

Formula

C22H16N4O
CAS 号

85-86-9
中文名称

苏丹红Ⅲ；苏丹红3号；苏丹红三号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 2.27 mg/mL (6.44 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8378 mL 14.1888 mL 28.3776 mL
5 mM 0.5676 mL 2.8378 mL 5.6755 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sakurai T, et al. Color Change of Sudan III against Concentrated Sulfuric Acid in Acetonitrile and Quantification for a Small Amount of Concentrated Sulfuric Acid. Anal Sci. 2016;32(2):129-33.