标签归档：protx

ProTx-1 品牌：Peptide

发表于由

ProTx-1

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-44091

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

ProTx-II 品牌：Peptide

发表于由

ProTx-II

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

335-44501

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

ProTx-I

发表于由

ProTx-I;

ProTx-I，一种 Thrixopelma pruriens 来源的毒素，是一种强效的选择性 CaV3.1 通道阻滞剂，对 hCaV3.1 和 hCaV3.2 的 IC50 值分别为 0.2 μM 和 31.8 μM。ProTx-I 还是电压门控 Na+ 通道的有效阻断剂，可抑制 KV 2.1 通道。

ProTx-Iamp;;

ProTx-I Chemical Structure

CAS No. : 484598-35-8

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生物活性

ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels[1][2].

IC50 Target

IC50: 0.2 μM (hCaV3.1) and 31.8 μM (hCaV3.2)[1]
Na+ channels[2]
KV 2.1 channels[2]
分子量

3988.00

Formula

C₁₇₁H₂₄₅N₅₃O₄₇S₆
CAS 号

484598-35-8
Sequence

Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys28)
Sequence Shortening

ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys28)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tsuyako Ohkubo, et al. Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. 2010;112(4):452-8.

    [2]. Richard E Middleton, et al. Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry. 2002 Dec 17;41(50):14734-47.

ProTx II

发表于由

ProTx II;

ProTx II 是 Nav1.7 钠通道的选择性阻滞剂，IC50 值为 0.3 nM，对 Nav1. 7的选择性是其他钠通道亚型的至少 100 倍。ProTx-II 通过降低通道电导和将激活的电压转移到更多的正电位来抑制钠离子通道，并阻止伤害感受器中动作电位的传播。

ProTx IIamp;;

ProTx II Chemical Structure

CAS No. : 484598-36-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

ProTx II is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. ProTx-II inhibits sodium channels by decreasing channel conductance and shifting activation to more positive potentials and blocks action potential propagation in nociceptors[1][2].

IC50 Target

IC50: 0.3 nM (NaV1.7), 41 nM (Nav1.2), 102 nM (NaV1.3), 39 nM (NaV1.4), 79 nM (NaV1.5), 26 nM (NaV1.6), 146 nM (NaV1.8)[1]
分子量

3826.59

Formula

C168H250N46O41S8
CAS 号

484598-36-9
Sequence Shortening

YCQKWMWTCDSERKCCEGMVCRLWCKKKLW (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.

    [2]. Schmalhofer WA, et al. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol. 2008 Nov;74(5):1476-84.