标签归档：ii

Angiotensin I/II (1-6)

发表于由

Angiotensin I/II (1-6);

Angiotensin I/II 1-6 含有 1-6 个氨基酸，由血管紧张素 I/II 肽转化而来。Angiotensin I 被血管紧张素转换酶 (ACE)水解形成具有生物活性的 angiotensin II。Angiotensin II 用于高血压、肾素-血管紧张素系统和特发性膜性肾病的研究。

Angiotensin I/II (1-6)amp;;

Angiotensin I/II (1-6) Chemical Structure

CAS No. : 47896-63-9

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Angiotensin I/II (1-6) 的其他形式现货产品:

Angiotensin I/II (1-6) (TFA)

生物活性

Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy[1][2][3].

体外研究
(In Vitro)

Angiotensin II is a naturally occurring octapeptide hormone component of the renin-angiotensin-aldosterone system (RAAS) and is a potent vasoconstrictor. Angiotensin II has important roles in cardiovascular, neurologic, and renal physiology, including maintenance of blood pressure, thirst sensation, response to the baroreceptor reflex, determination of renal blood flow and glomerular filtration rate, and electrolyte and free water homeostasis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

801.89

Formula

C36H55N11O10
CAS 号

47896-63-9
Sequence Shortening

DRVYIH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Erdös EG, et al. Conversion of angiotensin I to angiotensin II. Am J Med. 1976 May 31;60(6):749-59.

    [2]. Busse LW, et al. Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety. Crit Care Med. 2017;45(8):1285-1294.

    [3]. Angiotensin II

Restriction Endonuclease EcoO109 I (Dra II ) 品牌：Nippon Gene

发表于由

Restriction Endonuclease EcoO109 I (Dra II )

品牌：Nippon Gene
CAS No.：95725-92-1
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

310-01155

 – 1000U×10 – 咨询 – –


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Angiotensin II (5-8), human

发表于由

Angiotensin II (5-8), human;

Angiotensin II (5-8), human 是一种血管收缩肽血管紧张素II的内源性c端片段。Angiotensin II与AT II 1 型 (AT1)受体结合，刺激血管平滑肌细胞中的GPCRs，增加细胞内 Ca2+ 水平。Angiotensin II也在肾小管近端的Na+/H+交换器中起作用。

Angiotensin II (5-8), humanamp;;

Angiotensin II (5-8), human Chemical Structure

CAS No. : 34233-50-6

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生物活性

Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3].

分子量

512.60

Formula

C26H36N6O5
CAS 号

34233-50-6
Sequence

Ile-His-Pro-Phe
Sequence Shortening

IHPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27.

    [2]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411.

    [3]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5.

[Tyr(P)4] Angiotensin II

发表于由

[Tyr(P)4] Angiotensin II;

[Tyr(P)4] Angiotensin II 是一种多肽，在血管平滑肌细胞中有多种作用，包括正常动脉的收缩，培养的细胞或病变血管的肥大或增生等。

[Tyr(P)4] Angiotensin IIamp;;

[Tyr(P)4] Angiotensin II Chemical Structure

CAS No. : 129785-85-9

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生物活性

[Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels[1].

分子量

1126.20

Formula

C50H72N13O15P
CAS 号

129785-85-9
Sequence Shortening

DRV-{pTyr}-IHPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E A Kitas, et al. Chemical synthesis of an O-phosphorylated tyrosine analogue of human angiotensin II, [Tyr(P)4] angiotensin II, and its vasoconstrictor effect in intact sheep. Pept Res. Jul-Aug 1993;6(4):205-10.

Urocortin II, human TFA

发表于由

Urocortin II, human TFA;

Urocortin II, human (TFA) 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，用于研究 CRF2 受体在摄食行为中的作用。

Urocortin II, human TFAamp;;

Urocortin II, human TFA Chemical Structure

规格 是否有货
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生物活性

Urocortin II, human (TFA) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior[1].

IC50 Target

CRF2[1]
分子量

4564.30

Formula

C196H340F3N63O56S
Sequence Shortening

IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zorrilla EP,et al. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep;310(3):1027-34.

Angiotensin II (1-4), human

发表于由

Angiotensin II (1-4), human;

Angiotensin II (1-4), human 是一种由 AT I经血管紧张素转换酶(ACE)合成的内源性肽。Angiotensin II与AT II 1 型 (AT1)受体结合，刺激血管平滑肌细胞中的GPCRs，增加细胞内 Ca2+ 水平。Angiotensin II也在肾小管近端的Na+/H+交换器中起作用。

Angiotensin II (1-4), humanamp;;

Angiotensin II (1-4), human Chemical Structure

CAS No. : 52580-29-7

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[1][2].

分子量

551.59

Formula

C24H37N7O8
CAS 号

52580-29-7
Sequence

Asp-Arg-Val-Tyr
Sequence Shortening

DRVY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411.

    [2]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5.

10447800-Whatman 沃特曼 Minifold II系统

发表于由

产品型号10447800

品       牌沃特曼

厂商性质代理商

产品简介

72孔狭缝杂交系统 Whatman 沃特曼 Minifold II系统是专为高通量的精确定量固相分析而设计的，3排24狭缝的规格可以与高通量自动加样器兼容。更小的狭缝表面，保证了更高的信号强度以及比标准Dot-Blot更少的上样量。可以用光密度计检测结果。

详情介绍

名称 : Whatman 沃特曼 Minifold II系统

型号 :10447800

Whatman 沃特曼 Minifold II系统 10447800

详细描述

10447800

72孔狭缝杂交系统
Minifold? II系统是专为高通量的精确定量固相分析而设计的，3排24狭缝的规格可以与高通量自动加样器兼容。更小的狭缝表面，保证了更高的信号强度以及比标准Dot-Blot更少的上样量。可以用光密度计检测结果。

特性

  • 更高的信号强度 – 更小的狭缝表面，提高了信号密度
  • 更少的上样量 – 小的狭缝规格，使得所需样品量低于点杂交
  • 更快的检测结果 – 更高的信号强度，使得狭缝杂交实验者能更快得到检测结果
  • 适用所有类型的转印膜 – 可以选择使用zui高结合力的膜
  • 安装简单 – 斜角边框，确保更快速、准确地安装

10447800-Whatman 沃特曼 Minifold II系统

10447800

10447800, 10447801, 10447866, 10402493, 10402593

ProTx II

发表于由

ProTx II;

ProTx II 是 Nav1.7 钠通道的选择性阻滞剂，IC50 值为 0.3 nM，对 Nav1. 7的选择性是其他钠通道亚型的至少 100 倍。ProTx-II 通过降低通道电导和将激活的电压转移到更多的正电位来抑制钠离子通道，并阻止伤害感受器中动作电位的传播。

ProTx IIamp;;

ProTx II Chemical Structure

CAS No. : 484598-36-9

规格 是否有货
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500 mg ; 询价 ;

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生物活性

ProTx II is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. ProTx-II inhibits sodium channels by decreasing channel conductance and shifting activation to more positive potentials and blocks action potential propagation in nociceptors[1][2].

IC50 Target

IC50: 0.3 nM (NaV1.7), 41 nM (Nav1.2), 102 nM (NaV1.3), 39 nM (NaV1.4), 79 nM (NaV1.5), 26 nM (NaV1.6), 146 nM (NaV1.8)[1]
分子量

3826.59

Formula

C168H250N46O41S8
CAS 号

484598-36-9
Sequence Shortening

YCQKWMWTCDSERKCCEGMVCRLWCKKKLW (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.

    [2]. Schmalhofer WA, et al. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol. 2008 Nov;74(5):1476-84.

Angiotensin II (Human) 人血管紧张素 II 品牌：FUJIFILM Wako

发表于由

Angiotensin II (Human)

人血管紧张素 II<电离质谱校准物>

品牌：FUJIFILM Wako
CAS No.：4474-91-3
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

015-22933

 for Proteome Research 2 nmol×5本 –

Angiotensin II (Human) 人血管紧张素 II 品牌：FUJIFILM Wako

替代品：019-22931

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

(Sar1)-Angiotensin II

发表于由

(Sar1)-Angiotensin II;

(Sar1)-Angiotensin II，一种血管紧张素 II (Angiotensin II) 的类似物，是血管紧张素 AT1 受体的特异性激动剂。(Sar1)-Angiotensin II 以 2.7 nM 的 Kd 值结合到富含脑膜的颗粒上。(Sar1)-Angiotensin II 可以刺激雏鸡心肌细胞中的蛋白质合成和细胞生长。

(Sar1)-Angiotensin IIamp;;

(Sar1)-Angiotensin II Chemical Structure

CAS No. : 51833-69-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].

体外研究
(In Vitro)

(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively[2].
(Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a Kd of 2.7 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1002.17

Formula

C49H71N13O10
CAS 号

51833-69-3
Sequence Shortening

{Sar}-RVYIHPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38(23):4660-9.

    [2]. Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258(3 Pt 2):H806-13.

    [3]. Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11(2):243-53.