Pulchinenoside B 是从 Pulsatilla chinensis 中分离得到的一种三萜皂苷。
Pulchinenoside B Chemical Structure
CAS No. : 135247-95-9
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
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生物活性
Pulchinenoside B is a triterpenoid saponin isolated from Pulsatilla chinensis[1].
分子量
1075.24
Formula
C53H86O22
CAS 号
135247-95-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wan JY, et al. Biotransformation and metabolic profile of anemoside B4 with rat small and large intestine microflora by ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. Biomed Chromatogr. 2017;31(5):10.1002/bmc.3873.
Pulsatilla saponin D;(Synonyms: SB365; Hederacolchiside A) 纯度: 98.47%
Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到,具有抗癌活性。
Pulsatilla saponin D Chemical Structure
CAS No. : 68027-15-6
规格
价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥3977
In-stock
5 mg
¥1980
In-stock
10 mg
;
询价
;
50 mg
;
询价
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Pulsatilla saponin D 相关产品
bull;相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Natural Product Library
Anti-Cancer Compound Library
Glycoside Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library
Anti-Lung Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
生物活性
Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana Nakai, is an anti-tumor agent[1][2][3][4].
体外研究 (In Vitro)
Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase[1]. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells[1]. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) [2]. Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF[3]. Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay[4]
Cell Line:
A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.
Concentration:
0.3 ng/mL to 10 μg/mL.
Incubation Time:
72 h.
Result:
Exhibited an ED50 value of 6.3 μg/mL for A-549 cells.
体内研究 (In Vivo)
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4].
Dosage:
6.4 mg/kg.
Administration:
Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result:
Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).
分子量
913.10
Formula
C47H76O17
CAS 号
68027-15-6
中文名称
白头翁皂苷 D
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Hong SW, et al. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. Carcinogenesis. 2013 Sep;34(9):2156-69.
[2]. Son MK, et al. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Oncol Rep. 2013 Aug;30(2):801-8.
[3]. Son MK, et al. SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. Food Chem. 2013 Jan 1;136(1):26-33.
[4]. Yong Kim, et al. Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. Arch Pharm Res. 2004 Sep;27(9):915-8.