Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units[1]. Chitobiose has orally activity and high antioxidant activity[2].
体内研究 (In Vivo)
Chitobiose (30, 100, 300 mg/kg; p.o., single) can enters the circulatory system when given orally[2]. Pharmacokinetic Parameters of Chitobiose in Wistar strain male rats[2].
PO (30 mg/kg)
PO (100 mg/kg)
PO (300 mg/kg)
Tmax (h)
0.9
1.0
1.8
Cpmax (μg/mL)
1.1
4.4
6.9
AUC0-4h (μg·h/mL)
2.5
9.0
17.6
AUMC0-4h (μg·h^2/mL)
4.0
13.2
35.6
MRT (h)
1.6
1.5
1.6
MAT (h)
1.1
1.0
1.2
ka (h^-1)
0.95
0.99
0.96
F1-4h (%)
1.8
2.0
1.3
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Wistar strain male rats (7 weeks, 165-185 g)[2]
Dosage:
30, 100, 300 mg/kg
Administration:
p.o., single (Pharmacokinetics analysis)
Result:
Entered the circulatory system when given orally.
分子量
340.33
Formula
C12H24N2O9
CAS 号
577-76-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11.
[2]. Chen AS, Taguchi T, Okamoto H, et al. Pharmacokinetics of chitobiose and chitotriose administered intravenously or orally to rats. Biol Pharm Bull. 2005;28(3):545-548.
Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC50=6.6 μM)[1][2].
体外研究 (In Vitro)
Protoneogracillin shows activitie against P.oryzae (MMDC=94.0 μM) and K562 (IC50=6.6 μM)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1065.20
Formula
C51H84O23
CAS 号
191334-50-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Hu K, et, al. Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca. Planta Med. 1997 Apr;63(2):161-5.
[2]. Liu HW, et, al. New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth. J Asian Nat Prod Res. 2003 Dec;5(4):241-7.
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity[1][2].
体外研究 (In Vitro)
Niazinin, is cytotoxic at substantially higher concentration (CC50 of 31.6 µM) than its antileishmanial concentration (IC50 of 5.25 µM)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
343.40
Formula
C15H21NO6S
CAS 号
147821-57-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Amandeep Kaur, et al. Antileishmanial compounds from Moringa oleifera Lam. Z Naturforsch C J Biosci. Mar-Apr 2014;69(3-4):110-6.
[2]. Shiv Rakesh Naik, et al. Structure-based virtual screening, molecular dynamics and binding affinity calculations of some potential phytocompounds against SARS-CoV-2. J Biomol Struct Dyn. 2021 Mar 8;1-18.
上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
α-Amyrin acetate
α-Amyrin acetate，一种三萜类化合物，具有抗炎活性、抗痉挛特性和松弛作用。
α-Amyrin acetate Chemical Structure
CAS No. : 863-76-3
规格
价格
是否有货
5 mg
￥5500
询问价格 & 货期
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生物活性
α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect[1][2].
分子量
468.75
Formula
C32H52O2
CAS 号
863-76-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Okoye NN, et al. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei displayprofound anti-inflammatory activity. Pharm Biol. 2014 Nov;52(11):1478-86.
[2]. Ali N. Brine shrimp cytotoxicity of crude methanol extract and antispasmodic activity of α-amyrin acetate from Tylophora hirsuta wall. BMC Complement Altern Med. 2013 Jun 17;13:135.
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].
体外研究 (In Vitro)
Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1]. Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1]. Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1]. Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male Wistar rats (6-8 weeks old)[2].
Dosage:
50 mg/kg.
Administration:
Oral gavage an hour before inducing the lesions.
Result:
Decreased severity of the formed lesions.
分子量
464.38
Formula
C21H20O12
CAS 号
20229-56-5
中文名称
螺旋藻苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.
[2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.
Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC50 of 50.0 µM[1].
分子量
610.52
Formula
C27H30O16
CAS 号
22149-35-5
运输条件
Room temperature in continental US; may vary elsewhere.
Curculigoside B 是从虎杖中分离得到的酚苷类化合物，能促进成骨细胞增殖，减少骨吸收坑面积，减少破骨细胞形成和 TRAP 活性。具有抗骨质疏松和抗氧化活性。
Curculigoside B Chemical Structure
CAS No. : 143601-09-6
规格
价格
是否有货
1 mg
￥2000
询问价格 货期
* Please select Quantity before adding items.
生物活性
Curculigoside B, a phenolic glycoside isolated from Curculigo orchioides, enhances the osteoblast proliferation, decreases the area of bone resorption pit, osteoclastic formation and TRAP activity. Antiosteoporotic and antioxidative activities[1].
分子量
452.41
Formula
C21H24O11
CAS 号
143601-09-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jiao L, et al. Antiosteoporotic activity of phenolic compounds from Curculigo orchioides. Phytomedicine. 2009;16(9):874-881.
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia[1]. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol)[2]. Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity[3].
IC50 Target[1]
H1 Receptor
;
L-type calcium channel
;
分子量
366.32
Formula
C17H18O9
CAS 号
905954-17-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Chun-Feng Qiao, et al.Psoralenoside and isopsoralenoside, two new benzofuran glycosides from Psoralea corylifolia. Chem Pharm Bull (Tokyo). 2006 May;54(5):714-6.
[2]. Muhammad Bilal Riaz, et al. Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders. BMC Complement Altern Med. 2019 Dec 3;19(1):348.
[3]. Yue-Fei Wang, et al.A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. J Ethnopharmacol
