标签归档：nociceptin

Orphanin Pro FQ / Nociceptin-Propro (141-157) 品牌：Anygen

发表于由

Orphanin Pro FQ / Nociceptin-Propro (141-157)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-90581

 – 0.5 mg – 咨询 – –


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Orphanin FQ / [Des-Phe1]-Nociceptin 品牌：Anygen

发表于由

Orphanin FQ / [Des-Phe1]-Nociceptin

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-90601

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Nociceptin (1-13), amide TFA

发表于由

Nociceptin (1-13), amide TFA; 纯度: 99.95%

Nociceptin (1-13), amide TFA 是一种有效的阿片受体 ORL1 (OP4) 受体激动剂，对小鼠输精管 pEC50 值为 7.9，与大鼠前脑膜结合的 Ki 值为 0.75 nM。

Nociceptin (1-13), amide TFAamp;;

Nociceptin (1-13), amide TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥2100 In-stock
10 mg ￥3650 In-stock
50 mg ; 询价 ;
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Nociceptin (1-13), amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

Nociceptin (1-13), amide TFA is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

分子量

1495.61

Formula

C63H101F3N22O17
Sequence

Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2
Sequence Shortening

FGGFTGARKSARK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.

    [2]. Calo’ G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.

Orphanin Pro FQ / Nociceptin (85-119) / Pro-Nocistatin-35 (Human, Rat, Mouse, Ox) 品牌：Anygen

发表于由

Orphanin Pro FQ / Nociceptin (85-119) / Pro-Nocistatin-35 (Human, Rat, Mouse, Ox)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

308-36923

 – 0.5 mg – 咨询 – –


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Nociceptin (Human, Bovine, Rat, Mouse) 品牌：Peptide

发表于由

Nociceptin (Human, Bovine, Rat, Mouse)

品牌：Peptide
CAS No.：170713-75-4
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

333-43181

 – 0.5mg – 咨询 – –


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Nociceptin 品牌：FUJIFILM Wako

发表于由

Nociceptin

品牌：FUJIFILM Wako
CAS No.：170713-75-4
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

144-07211

 for Biochemistry 1 mg –

Nociceptin 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[Arg14,Lys15]Nociceptin

发表于由

[Arg14,Lys15]Nociceptin;

[Arg14,Lys15]Nociceptin 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptinamp;;

[Arg14,Lys15]Nociceptin Chemical Structure

CAS No. : 236098-40-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1909.16

Formula

C82H137N31O22
CAS 号

236098-40-1
Sequence Shortening

FGGFTGARKSARKRKNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

[(pF)Phe4]Nociceptin(1-13)NH2

发表于由

[(pF)Phe4]Nociceptin(1-13)NH2;

[(pF)Phe4]Nociceptin(1-13)NH2 是一种高效、选择性的 NOP 受体 (OP4) 激动剂，pKi 为 10.68，pEC50 为 9.31。[(pF)Phe4]Nociceptin(1-13)NH2 对 δ、κ 和 μ 阿片受体具有较高的选择性 (>3000 倍)。

[(pF)Phe4]Nociceptin(1-13)NH2amp;;

[(pF)Phe4]Nociceptin(1-13)NH2 Chemical Structure

CAS No. : 380620-88-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].

体内研究
(In Vivo)

In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1399.58

Formula

C61H99FN22O15
CAS 号

380620-88-2
Sequence Shortening

FGG{Phe(4-F)}TGARKSARK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456.

    [2]. Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449.

    [3]. Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964.

[Arg14,Lys15]Nociceptin TFA

发表于由

[Arg14,Lys15]Nociceptin TFA;

[Arg14,Lys15]Nociceptin TFA 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin TFA 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptin TFAamp;;

[Arg14,Lys15]Nociceptin TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin TFA is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin TFA mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2023.18

Formula

C84H138F3N31O24
Sequence Shortening

FGGFTGARKSARKRKNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

[Nphe1]Nociceptin(1-13)NH2 TFA

发表于由

[Nphe1]Nociceptin(1-13)NH2 TFA;

[Nphe1]Nociceptin(1-13) NH2 TFA 是一种 Nociceptin/orphanin FQ (NC) 内源性配体，是一种选择性和竞争性的 ociceptin receptor 拮抗剂，不具有激动剂活性。[Nphe1]nociceptin(1-13)NH2 选择性结合重组 nociceptin 受体(pKi=8.4)，拮抗 nociceptin 对 CHO 细胞中 cAMP 积累的抑制作用(pA2=6.0)。[Nphe1]Nociceptin(1-13)NH2 有可能作为一种止痛试剂。

[Nphe1]Nociceptin(1-13)NH2 TFAamp;;

[Nphe1]Nociceptin(1-13)NH2 TFA Chemical Structure

规格 是否有货
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生物活性

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].

体外研究
(In Vitro)

[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0) .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1495.61

Formula

C63H101F3N22O17
Sequence Shortening

Bn-GGGFTGARKSARK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor

    [2]. G Calo’, et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1183-93.