Hosenkoside B

发表于2024年10月2日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Hosenkoside B; 纯度: 96.23%

Hosenkoside B是从凤仙花种子中分离出的一种糖苷。

Hosenkoside B Chemical Structure

CAS No. : 156764-82-8

规格	价格	是否有货	数量
5 mg	￥2800	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Hosenkoside B is a baccharane glycoside isolated from the seeds of impatiens balsamina.

分子量

979.15

Formula

C₄₈H₈₂O₂₀

CAS 号

156764-82-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

参考文献

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Hosenkoside K

发表于2024年9月30日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Hosenkoside K; 纯度: 98.61%

Hosenkoside K是从凤仙花种子中分离出的一种糖苷。

Hosenkoside K Chemical Structure

CAS No. : 160896-49-1

规格	价格	是否有货	数量
5 mg	￥1900	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

Hosenkoside K 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library

生物活性

Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.

体内研究
(In Vivo)

The mean peak concentrations of hosenkoside K in rats after oral administration of total saponins of Semen Impatientis is 511.11±234.07 ng/mL, occurring at times of 0.46 h. The terminal half-lives of hosenkoside A is 4.96±1.75 h^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1141.29

Formula

C₅₄H₉₂O₂₅

CAS 号

160896-49-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (87.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8762 mL	4.3810 mL	8.7620 mL
5 mM	0.1752 mL	0.8762 mL	1.7524 mL
10 mM	0.0876 mL	0.4381 mL	0.8762 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.19 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.19 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.19 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Animal Administration	Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Animal Administration

Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Hosenkoside A

发表于2024年9月29日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Hosenkoside A; 纯度: 99.38%

Hosenkoside A是从凤仙花种子中分离出的一种糖苷。

Hosenkoside A Chemical Structure

CAS No. : 156791-82-1

规格	价格	是否有货	数量
5 mg	￥1900	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

Hosenkoside A 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library

生物活性

Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina.

体内研究
(In Vivo)

The mean peak concentrations of hosenkoside A in rats after oral administration of total saponins of Semen Impatientis is 162.08±139.87 ng/mL, occurring at times of 0.67 h. The terminal half-lives of hosenkoside A is 5.39±2.06h^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

979.15

Formula

C₄₈H₈₂O₂₀

CAS 号

156791-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 50 mg/mL (51.06 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0213 mL	5.1065 mL	10.2129 mL
5 mM	0.2043 mL	1.0213 mL	2.0426 mL
10 mM	0.1021 mL	0.5106 mL	1.0213 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.55 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.55 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.55 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.55 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.55 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.55 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Animal Administration	Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

Enfumafungin

发表于2024年5月21日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Enfumafungin 纯度: 98.45%

Enfumafungin，一种三萜糖苷，是从 Hormonema 内生物种的提取物中分离得到的。Enfumafungin 是一种抗真菌化合物，可作为 (1,3)-beta-D-葡聚糖合酶抑制剂作用在真菌细胞壁上。Enfumafungin 对酵母和真菌（隐球菌除外）具有特异性，不抑制枯草芽孢杆菌的生长。

Enfumafungin Chemical Structure

CAS No. : 260979-95-1

规格	价格	是否有货
5 mg	￥2200	In-stock
10 mg	￥3600	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Enfumafungin 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Natural Product Library
Glycoside Compound Library
Antifungal Compound Library
Microbial Metabolite Library

生物活性

Enfumafungin, a triterpene glycoside, is isolated from extracts derived from an endophytic species of Hormonema. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis^[1]^[2].

IC₅₀ & Target

(1,3)-beta-D-glucan synthase^[1]

体外研究
(In Vitro)

Enfumafungin (24-48 h) has MICs of less than 0.5 μg/mL against the Candida and Aspergillus species tested and it is inactive against Cryptococcus, including the decapsulated form (MY2062)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Enfumafungin (50-200 mg/kg; i.p. twice daily for 2 days) produces a significant decrease in the number of c.f.u. in kidneys of mice challenged with C. albicans, with an ED₉₀ of 90 mg/kg^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

708.88

Formula

C₃₈H₆₀O₁₂

CAS 号

260979-95-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (141.07 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4107 mL	7.0534 mL	14.1068 mL
5 mM	0.2821 mL	1.4107 mL	2.8214 mL
10 mM	0.1411 mL	0.7053 mL	1.4107 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.53 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.53 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.53 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Peláez F, et, al. The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms. Syst Appl Microbiol. 2000 Oct;23(3):333-43.

[2]. Onishi J, et, al. Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother. 2000 Feb;44(2):368-77.

Genipin 1-β-D-gentiobioside(Synonyms: 京尼平龙胆双糖苷; Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside)

发表于2024年4月21日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Genipin 1-β-D-gentiobioside;(Synonyms: 京尼平龙胆双糖苷; Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside) 纯度: 99.56%

Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) 是栀子中最丰富和具有生物活性的环烯醚萜苷之一，具有保肝，抗炎，抗氧化和抗血栓形成活性。

Genipin 1-β-D-gentiobioside Chemical Structure

CAS No. : 29307-60-6

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥1510	In-stock
5 mg	￥1250	In-stock
10 mg	￥2000	In-stock
25 mg	￥4000	In-stock
50 mg	￥7500	In-stock
100 mg	;	询价	;
200 mg	;	询价	;

* Please select Quantity before adding items.

Genipin 1-beta;-D-gentiobioside 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library

生物活性

Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

体内研究
(In Vivo)

Genipin 1-β-D-gentiobioside (Genipin gentiobioside) has moderate terminal elimination half-life (t_1/2=1.65±0.87 h and 2.43±2.30 h for nomal rats (11.4 mg/kg) and cholestatic liver injury (CLI) rats (11.4 mg/kg), respectively)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

550.51

Formula

C₂₃H₃₄O₁₅

CAS 号

29307-60-6

中文名称

京尼平-1-β-D-龙胆双糖苷；京尼平龙胆双糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据

In Vitro:;

Ethanol : 125 mg/mL (227.06 mM; Need ultrasonic)

DMSO : 100 mg/mL (181.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8165 mL	9.0825 mL	18.1650 mL
5 mM	0.3633 mL	1.8165 mL	3.6330 mL
10 mM	0.1816 mL	0.9082 mL	1.8165 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.54 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.54 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.54 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Zhu H, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:116-25.

Animal Administration ^[1]	Rats^[1] Twelve male rats are divided randomly into normal and acute cholestatic liver injury (CLI) group, with 6 rats in each. The rats are kept in an air-conditioned environment at a temperature of 22-24°C and a relative humidity of 50±10%, with access to the standard laboratory food and water. After fasted for 12 h, the rats are given Zhi-Zi-Da-Huang decoction (ZZDHD) at a dose of 8 g/kg (crude drug/body weight, equivalent to 35.9 mg/kg geniposide, 11.4 mg/kg Genipin 1-β-D-gentiobioside, 2.50 mg/kg Rhein, 0.23 mg/kg Emodin, 11.2 mg/kg Isonaringin, 83.5 mg/kg Naringin, 12.4 mg/kg Hesperidin and 79.6 mg/kg Neohesperidin) by oral administration. Blood samples (approximately 0.3 mL) are collected from the fosse orbital vein using heparinized 1.5 mL polythene tubes before the dose and at 0.08, 0.17, 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 24, 36 and 48 h after dosing, and then centrifuged immediately at 13,000 rpm for 5 min. Plasma is transferred into clean tubes and stored at -80°C until analysis^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Zhu H, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:116-25.

Animal Administration
^[1]

Rats^[1]
Twelve male rats are divided randomly into normal and acute cholestatic liver injury (CLI) group, with 6 rats in each. The rats are kept in an air-conditioned environment at a temperature of 22-24°C and a relative humidity of 50±10%, with access to the standard laboratory food and water. After fasted for 12 h, the rats are given Zhi-Zi-Da-Huang decoction (ZZDHD) at a dose of 8 g/kg (crude drug/body weight, equivalent to 35.9 mg/kg geniposide, 11.4 mg/kg Genipin 1-β-D-gentiobioside, 2.50 mg/kg Rhein, 0.23 mg/kg Emodin, 11.2 mg/kg Isonaringin, 83.5 mg/kg Naringin, 12.4 mg/kg Hesperidin and 79.6 mg/kg Neohesperidin) by oral administration. Blood samples (approximately 0.3 mL) are collected from the fosse orbital vein using heparinized 1.5 mL polythene tubes before the dose and at 0.08, 0.17, 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 24, 36 and 48 h after dosing, and then centrifuged immediately at 13,000 rpm for 5 min. Plasma is transferred into clean tubes and stored at -80°C until analysis^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Zhu H, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:116-25.

Rhoifolin(Synonyms: 野漆树苷)

发表于2024年4月20日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Rhoifolin;(Synonyms: 野漆树苷) 纯度: 99.24%

Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌，胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。

Rhoifolin Chemical Structure

CAS No. : 17306-46-6

规格	价格	是否有货	数量
5 mg	￥500	In-stock
10 mg	￥900	In-stock
20 mg	￥1500	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Rhoifolin 相关产品

bull;相关化合物库:

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Protein Tyrosine Kinase Compound Library
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Anti-Cancer Compound Library
Autophagy Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Diabetes Related Compound Library
Glycoside Compound Library
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Endocrinology Compound Library
Phenols Library
Glycolysis Compound Library
Pyroptosis Compound Library
Glutamine Metabolism Compound Library
Traditional Chinese Medicine Monomer Library
Anti-Lung Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Cancer Metabolism Compound Library
Neurodegenerative Disease-related Compound Library
Angiogenesis Related Compound Library
Transcription Factor Targeted Library
Glucose Metabolism Compound Library
Food-Sourced Compound Library

生物活性

Rhoifolin is a flavone glycoside isolated from Citrus grandis (L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation^[1]. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways^[2].

IC₅₀ Target^[1]^[2]

insulin receptor-β

;

GLUT4

;

NF-κB

;

MAPK

;

分子量

578.52

Formula

C₂₇H₃₀O₁₄

CAS 号

17306-46-6

中文名称

野漆树苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:;

DMSO : 62.5 mg/mL (108.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7285 mL	8.6427 mL	17.2855 mL
5 mM	0.3457 mL	1.7285 mL	3.4571 mL
10 mM	0.1729 mL	0.8643 mL	1.7285 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.08 mg/mL (3.60 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.60 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.60 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.60 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.60 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.60 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.

[2]. Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.

2”-O-Rhamnosylicariside II

发表于2024年3月28日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

2”-O-Rhamnosylicariside II; 纯度: 98.51%

2”-O-Rhamnosylicariside II 是一种黄酮类糖苷化合物，可能对改善绝经后骨质疏松有益处。

2”-O-Rhamnosylicariside II Chemical Structure

CAS No. : 135293-13-9

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥4230	In-stock
5 mg	￥2910	In-stock
10 mg	￥4950	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

2”-O-Rhamnosylicariside II 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Glycoside Compound Library
Phenols Library
Flavonoids Library

生物活性

2”-O-Rhamnosylicariside II is a flavonoid glycoside compound and might be beneficial for improving postmenopausal osteoporosis.

分子量

660.66

Formula

C₃₃H₄₀O₁₄

CAS 号

135293-13-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (151.36 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5136 mL	7.5682 mL	15.1364 mL
5 mM	0.3027 mL	1.5136 mL	3.0273 mL
10 mM	0.1514 mL	0.7568 mL	1.5136 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.78 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.78 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.78 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.78 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Zhao BJ, et al. Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats. Planta Med. 2016 Mar;82(4):322-9.

甲基α-D-吡喃甘露糖苷 MMP（Methyl α-D-Mannopyranoside）

发表于2024年3月27日由Whatman官网

甲基α-D-吡喃甘露糖苷
MMP（Methyl α-D-Mannopyranoside）

产品特性
相关资料
Q&A
参考文献

甲基α-D-吡喃甘露糖苷

MMP（Methyl α-D-Mannopyranoside）

甲基α-D-吡喃甘露糖苷（MMP）常用于疫苗等纯化过程中糖蛋白和多肽的纯化。

本产品为应用于R＆D阶段的药物研究级试剂，生产方法与药物生产级原料药的方法相同，并可根据客户需求，快速切换为药物生产级原料药，以应对生产工艺的放大。

◆产品规格

甲基α-D-吡喃甘露糖苷 MMP（Methyl α-D-Mannopyranoside）

纯度：＞99.0%（HPLC）

生产商：FUJIFILM Wako Pure Chemical Corporation

保存条件 : 室温

CAS RN^®: 617-04-9

分子式 : C₇H₁₄O₆

分子量 : 194.18

外观：白色结晶~粉末

融点：191～197℃

比旋光度：[α]_D²⁰ +77～+81°(c=10,H₂O)

◆应用示例

●　冠状病毒重组亚单位疫苗制备中的蛋白纯化^[1]

甲基α-D-吡喃甘露糖苷 MMP（Methyl α-D-Mannopyranoside）

方法引自：McPherson et al., 2016

点击此处下载产品宣传页

※ 本页面产品仅供研究用，研究以外不可使用。

参考文献

1.	McPherson, C., Chubet, R., Holtz, K., Honda-Okubo, Y., Barnard, D., Cox, M., & Petrovsky, N. (2016). Development of a SARS coronavirus vaccine from recombinant spike protein plus delta inulin adjuvant. In Vaccine Design (pp. 269-284). Humana Press, New York, NY.

产品列表

产品编号	产品名称	产品规格	产品等级	备注
133-19191	Methyl α-D-Mannopyranoside 甲基-α-D-吡喃甘露糖苷	100 g
139-19193	Methyl α-D-Mannopyranoside 甲基-α-D-吡喃甘露糖苷	1 kg

Isovitexin 2”-O-arabinoside(Synonyms: 异牡荆素-2”-O-阿拉伯糖苷)

发表于2024年3月23日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Isovitexin 2”-O-arabinoside;(Synonyms: 异牡荆素-2”-O-阿拉伯糖苷) 纯度: 99.49%

Isovitexin 2”-O-arabinoside 是 Avena sativa L. 幼苗中的一种非活性类黄酮。

Isovitexin 2”-O-arabinoside Chemical Structure

CAS No. : 53382-71-1

规格	价格	是否有货	数量
5 mg	￥4000	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

Isovitexin 2”-O-arabinoside 相关产品

bull;相关化合物库:

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Phenols Library
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生物活性	Isovitexin 2”-O-arabinoside is an inactive flavonoid in plantlets of Avena sativa L. (Poaceae)^[1].
分子量	564.49
Formula	C₂₆H₂₈O₁₄
CAS 号	53382-71-1
中文名称	异牡荆素-2”-O-阿拉伯糖苷
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4deg;C, sealed storage, away from moisture and light *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Anne Mandeau, et al. Rhealba® oat plantlet extract: evidence of protein-free content and assessment of regulatory activity on immune inflammatory mediators. Planta Med. 2011 Jun;77(9):900-6.

Methyl α-D-Mannopyranoside 甲基-α-D-吡喃甘露糖苷品牌：FUJIFILM Wako

发表于2024年3月22日由Whatman官网

Methyl α-D-Mannopyranoside

甲基-α-D-吡喃甘露糖苷

品牌：FUJIFILM Wako
CAS No.：617-04-9
储存条件：室温
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
139-08022	Wako Special Grade	25g	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

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标签归档：糖苷

Hosenkoside B

Hosenkoside K

Hosenkoside K 相关产品

bull;相关化合物库:

Hosenkoside A

Hosenkoside A 相关产品

bull;相关化合物库:

Enfumafungin

Enfumafungin 相关产品

•相关化合物库:

Genipin 1-β-D-gentiobioside(Synonyms: 京尼平龙胆双糖苷; Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside)

Genipin 1-beta;-D-gentiobioside 相关产品

bull;相关化合物库:

Rhoifolin(Synonyms: 野漆树苷)

Rhoifolin 相关产品

bull;相关化合物库:

2”-O-Rhamnosylicariside II

2”-O-Rhamnosylicariside II 相关产品

bull;相关化合物库:

甲基α-D-吡喃甘露糖苷 MMP（Methyl α-D-Mannopyranoside）

Isovitexin 2”-O-arabinoside(Synonyms: 异牡荆素-2”-O-阿拉伯糖苷)

Isovitexin 2”-O-arabinoside 相关产品

bull;相关化合物库:

Methyl α-D-Mannopyranoside 甲基-α-D-吡喃甘露糖苷品牌：FUJIFILM Wako

Methyl α-D-Mannopyranoside

甲基-α-D-吡喃甘露糖苷