Hexa-N-acetylchitohexaose

天然产物 糖类和糖苷 Saccharides and Glycosides

Hexa-N-acetylchitohexaose;

Hexa-N-acetylchitohexaose 是作物抗病性的诱导剂,可诱导大豆木质化相关酶和抗氧化酶活性的增加。Hexa-N-acetylchitohexaose 是溶菌酶的底物。Hexa-N-acetylchitohexaose 具有抗肿瘤作用。

Hexa-N-acetylchitohexaose

Hexa-N-acetylchitohexaose Chemical Structure

CAS No. : 38854-46-5

规格 价格 是否有货
1 mg ¥2200 询问价格 货期

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生物活性

Hexa-N-acetylchitohexaose is an inducer of disease resistance in crop plants, which could elicit an increase of lignification-related and antioxidative enzymes in soybean plants. Hexa-N-acetylchitohexaose is a substrate of lysozyme. Hexa-N-acetylchitohexaose shows antitumor effect[1][2][3].

体内研究
(In Vivo)

On sarcoma 180 solid tumor in ddY mice using lentinan, an antitumorβ-D-glucan, as the positive control. Hexa-N-acetylchitohexaose (100 mg/kg/day; 3 times; intravenous ) significantly inhibits the growth of this allogenic solid tumor, affording a high tumor growth-inhibition ratio (85%) at 7 days after tumor implantation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1237.17

Formula

C48H80N6O31

CAS 号

38854-46-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li K, et al. Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation. Biomed Res Int. 2017;2017:2486515.

    [2]. David C. Phillips. THE HEN EGG-WHITE LYSOZYME MOLECULE. Proc Natl Acad Sci U S A. 1967 Mar; 57(3): 483-495.

    [3]. Suzuki K, et al. Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose. Carbohydr Res. 1986;151:403-408.

Hexa-D-arginine TFA(Synonyms: Furin Inhibitor II TFA)

Hexa-D-arginine TFA;(Synonyms: Furin Inhibitor II TFA)

Hexa-D-arginine TFA (Furin Inhibitor II TFA) 是一种稳定的 furin 抑制剂,对 furin,PACE4 和 PC1 的 Ki 值分别为 106 nM,580 nM 和 13.2 μM。Hexa-D-arginine TFA 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

Hexa-D-arginine TFAamp;;(Synonyms: Furin Inhibitor II TFA)

Hexa-D-arginine TFA Chemical Structure

CAS No. : 958204-56-3

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250 mg ; 询价 ;
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Hexa-D-arginine TFA 的其他形式现货产品:

Hexa-D-arginine

生物活性

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

IC50 Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]

体外研究
(In Vitro)

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1068.17

Formula

C38H76F3N25O8

CAS 号

958204-56-3

Sequence

Arg-Arg-Arg-Arg-Arg-Arg-NH2

Sequence Shortening

RRRRRR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.

    [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.

    [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.

Hexa-His

Hexa-His; 纯度: 98.62%

Hexa-His 是由 6 个组氨酸构成的六肽,常作为融合蛋白的金属结合位点。

Hexa-Hisamp;;

Hexa-His Chemical Structure

CAS No. : 64134-30-1

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥1572 In-stock
5 mg ¥1100 In-stock
10 mg ¥1700 In-stock
25 mg ¥3900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Hexa-His 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library

生物活性

Hexa-His is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein.

分子量

840.85

Formula

C36H44N18O7

CAS 号

64134-30-1

Sequence

His-His-His-His-His-His

Sequence Shortening

HHHHHH

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (59.46 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1893 mL 5.9464 mL 11.8927 mL
5 mM 0.2379 mL 1.1893 mL 2.3785 mL
10 mM 0.1189 mL 0.5946 mL 1.1893 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Watly J, et al. Insight into the coordination and the binding sites of Cu(2+) by the histidyl-6-tag using experimental and computational tools. Inorg Chem. 2014 Jul 7;53(13):6675-83.

Hexa-D-arginine(Synonyms: Furin Inhibitor II)

Hexa-D-arginine;(Synonyms: Furin Inhibitor II) 纯度: 99.57%

Hexa-D-arginine (Furin Inhibitor II) 是一种稳定的 furin 抑制剂,对 furin,PACE4 和 PC1 的 Ki 值分别为 106 nM,580 nM 和 13.2 μM。Hexa-D-arginine 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

Hexa-D-arginineamp;;(Synonyms: Furin Inhibitor II)

Hexa-D-arginine Chemical Structure

CAS No. : 673202-67-0

规格 价格 是否有货 数量
1 mg ¥950 In-stock
5 mg ¥3800 In-stock
10 mg ¥6800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Hexa-D-arginine 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

IC50 Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]

体外研究
(In Vitro)

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

954.14

Formula

C36H75N25O6

CAS 号

673202-67-0

Sequence Shortening

RRRRRR-NH2

中文名称

六-D-精氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (52.40 mM; Need ultrasonic)

DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0481 mL 5.2403 mL 10.4806 mL
5 mM 0.2096 mL 1.0481 mL 2.0961 mL
10 mM 0.1048 mL 0.5240 mL 1.0481 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.

    [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.

    [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.

Hexamethylquercetagetin(Synonyms: Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3′,4′-Hexamethoxyflavone)

天然产物 黄酮类 Flavonoids

Hexamethylquercetagetin (Synonyms: Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3′,4′-Hexamethoxyflavone)

Hexamethylquercetagetin 是柑橘皮中的一种多甲氧基黄酮类化合物。

Hexamethylquercetagetin(Synonyms: Hexa-O-methylquercetagetin;  Quercetagetin hexamethyl ether;  3,5,6,7,3

Hexamethylquercetagetin Chemical Structure

CAS No. : 1251-84-9

规格 价格 是否有货
1 mg ¥7000 询问价格 & 货期
5 mg ¥17500 询问价格 & 货期
10 mg ¥28000 询问价格 & 货期

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生物活性

Hexamethylquercetagetin is a polymethoxylated flavone in peels of citrus cultivars.

分子量

402.39

Formula

C21H22O8

CAS 号

1251-84-9

中文名称

3,5,6,7,3′,4′-六甲氧基黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Green CO, et al. Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. Biomed Chromatogr. 2007 Jan;21(1):48-54.