PR-39;
PR-39 是富含脯氨酸和精氨酸的天然抗菌肽，是一种非竞争性，可逆和变构的蛋白酶体 (proteasome) 抑制剂。PR-39 可逆地结合到蛋白酶体的 α7 亚基上，并通过泛素-蛋白酶体途径阻断 NF-κB 抑制剂 IκBα 的降解。PR-39 刺激小鼠的血管生成，抑制炎症反应并显着减小心肌梗死面积。
PR-39 Chemical Structure
CAS No. : 139637-11-9
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
PR-39 的其他形式现货产品:
| 生物活性 |
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice[1][2]. |
||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 (In Vitro) |
PR-39, shown to selectively affect proteasomemediated protein degradation in vivo, alters the shape of the 20S and 26S cylinder and affects the binding of 19S caps in a reversible manner. PR-39 specifically blocks degradation of IκBα and HIF-1α by the proteasome[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||||||
| 体内研究 (In Vivo) |
PR-39 (10 mg/kg, intravenously; 1 hour before Caerulein of 50μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||||||
| 分子量 |
4719.74 |
||||||||||||||||||||
| Formula |
C229H346N70O40 |
||||||||||||||||||||
| CAS 号 |
139637-11-9 |
||||||||||||||||||||
| Sequence Shortening |
RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2 |
||||||||||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||||||
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||||||||||||||
| Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
|
||||||||||||||||||||
| 参考文献 |
|