Enbucrilate(Synonyms: Butyl cyanoacrylate)

生化分析试剂 Biochemical Assay Reagents
Enbucrilate;(Synonyms: Butyl cyanoacrylate) 纯度: ge;98.0%

Enbucrilate (Butyl cyanoacrylate) 是一种氰基丙烯酸酯,已被用作手术组织粘合剂。

Enbucrilate(Synonyms: Butyl cyanoacrylate)

Enbucrilate Chemical Structure

CAS No. : 6606-65-1

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100 mg ¥500 In-stock
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Enbucrilate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Enbucrilate (Butyl cyanoacrylate) is a cyanoacrylate ester that has been used as surgical tissue adhesive.

体内研究
(In Vivo)

Enbucrilate offers an important intervention in gastric variceal bleeding which should be further studied in the US. A randomized trial is warranted to compare this intervention to radiological therapy[1]. The tissue adhesive Enbucrilate seems to be a safe, efficient agent to obtain good results in a simple, quick approach in the surgical treatment of symptomatic nephroptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

153.18

Formula

C8H11NO2

CAS 号

6606-65-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20deg;C 3 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (652.83 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.5283 mL 32.6413 mL 65.2827 mL
5 mM 1.3057 mL 6.5283 mL 13.0565 mL
10 mM 0.6528 mL 3.2641 mL 6.5283 mL

*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: 2.5 mg/mL (16.32 mM); Clear solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (16.32 mM) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (16.32 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (16.32 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (16.32 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Caldwell SH, et al. Enbucrilate for gastric varices: extended experience in 92 patients. Aliment Pharmacol Ther. 2007 Jul 1;26(1):49-59.

    [2]. Gyftopoulos KI, et al. The use of the tissue adhesive enbucrilate (histoacryl) in the treatment of symptomatic nephroptosis. Urol Int. 2002;69(4):313-7.

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