标签归档：ara

Vidarabine(Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Vidarabine;(Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine) 纯度: ge;98.0%

Vidarabine (Ara-A) 是核苷类抗生素，分离自链霉菌，能抗单纯性疱疹和水痘-带状疱疹病毒。Vidarabine 对 HSV-1 和 HSV-2 的 IC50 值分别为 9.3 μg/ml 和 11.3 μg/ml。

Vidarabine(Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)

Vidarabine Chemical Structure

CAS No. : 5536-17-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg ￥800 In-stock
500 mg ￥1200 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Vidarabine 相关产品

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  • Glycoside Compound Library
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  • FDA Approved amp; Pharmacopeial Drug Library
  • Antibiotics Library
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  • Anti-Blood Cancer Compound Library
  • Anti-Cancer Metabolism Compound Library

生物活性

Vidarabine (Ara-A) an antiviral drug which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2].

IC50 Target

HSV-1

9.3 mu;g/mL (IC50)

HSV-2

11.3 mu;g/mL (IC50)

体外研究
(In Vitro)

Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

267.24

Formula

C10H13N5O4
CAS 号

5536-17-4
中文名称

阿糖腺苷；腺嘌呤阿糖苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (187.10 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7420 mL 18.7098 mL 37.4195 mL
5 mM 0.7484 mL 3.7420 mL 7.4839 mL
10 mM 0.3742 mL 1.8710 mL 3.7420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.35 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.35 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.35 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20(4): p. 267-82.

    [2]. Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72(2):157-161.

[Ara3]CLV3 Peptide [Ara3]CLV3多肽 品牌：Peptide

发表于由

[Ara3]CLV3 Peptide

[Ara3]CLV3多肽

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-00911

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4) 抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4） 品牌：FUJIFILM Wako

发表于由

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4)

抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4）

品牌：FUJIFILM Wako
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

011-27131

 for Immunochemistry 10uL –

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4) 抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4） 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4) 抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4） 品牌：FUJIFILM Wako

发表于由

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4)

抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4）

品牌：FUJIFILM Wako
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

017-27133

 for Immunochemistry 50uL –

Anti Human ARaiv1, Rat Monoclonal Antibody(ARA1-1-7H4) 抗人ARaiv1，大鼠单克隆抗体（ARA1-1-7H4） 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Genistin, 99+%(HPLC) 品牌：Nagara Science

发表于由

Genistin, 99+%(HPLC)

品牌：Nagara Science
CAS No.：529-59-9
储存条件：暗所
纯度：99+%(HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

636-42841

 – 10mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Cibinetide(Synonyms: ARA290)

发表于由

Cibinetide;(Synonyms: ARA290) 纯度: 99.81%

Cibinetide (ARA290) 是一种 EPO 衍生物，为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂，常用于神经系统疾病研究。

Cibinetideamp;;(Synonyms: ARA290)

Cibinetide Chemical Structure

CAS No. : 1208243-50-8

规格 价格 是否有货 数量
1 mg ￥2000 In-stock
5 mg ￥6000 In-stock
10 mg ￥9500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Cibinetide 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for neurological disease treatment.

体外研究
(In Vitro)

Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs)[1]. Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation[1]. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats[2]. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1257.31

Formula

C51H84N16O21
CAS 号

1208243-50-8
Sequence Shortening

{Glp}-EQLERALNSS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 34 mg/mL (27.04 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7953 mL 3.9767 mL 7.9535 mL
5 mM 0.1591 mL 0.7953 mL 1.5907 mL
10 mM 0.0795 mL 0.3977 mL 0.7953 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors’ Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7

    [2]. Carole Muller, et al. ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats. Mol Med. 2015; 21(1): 969–978

    [3]. Chen H, et al. Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat. J Neuroimmunol. 2014 Mar 15;268(1-2):64-70
Animal Administration
[2]

Diabetic Goto-Kakizaki (GK) rats, originating from Wistar rats, are bred in our department. Normal Wistar (W) rats are used as nondiabetic controls. All animals are about six weeks old and with body weights 100 to 150 g when treatment is initiated. They are kept at 22°C on a reversed 12-h light-dark cycle with free access to food, except when fasted overnight as noted below. Rats are treated over 4 wks with Cibinetide by a once daily subcutaneous (s.c.) injection at a dose of 30 μg/kg body weight or PBS. Blood samples for determination of glucose are taken after a small tail incision and analyzed every week before morning s.c. injection of either Cibinetide or placebo. During the experimental period, body weights are measured weekly.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors’ Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7

    [2]. Carole Muller, et al. ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats. Mol Med. 2015; 21(1): 969–978

    [3]. Chen H, et al. Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat. J Neuroimmunol. 2014 Mar 15;268(1-2):64-70