天然产物 黄酮类 Flavonoids
Chrysosplenetin (Synonyms: 猫眼草黄素) 纯度: 99.52%
Chrysosplenetin 是青蒿 (Artemisia annua) 和其他几种中草药中的多甲氧基化黄酮类化合物之一。 Chrysosplenetin 抑制P-gp 活性并逆转由青蒿素 (ART) 诱导的上调的 P-gp 和 MDR1 水平。 Chrysosplenetin 显着增强 ART 在大鼠血浆水平和抗疟疾功效,部分因为其对大鼠 CYP3A 的非竞争性抑制作用。
Chrysosplenetin Chemical Structure
CAS No. : 603-56-5
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥2970 | In-stock | |
10 mg | ¥5040 | In-stock | |
20 mg | ¥8570 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Chrysosplenetin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Metabolism/Protease Compound Library
- Natural Product Library
- Anti-Aging Compound Library
- Antioxidants Compound Library
- Oxygen Sensing Compound Library
- Ferroptosis Compound Library
- Phenols Library
- Traditional Chinese Medicine Monomer Library
- Flavonoids Library
- Food-Sourced Compound Library
生物活性 |
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. |
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IC50 & Target[1] |
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分子量 |
374.34 |
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Formula |
C19H18O8 |
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CAS 号 |
603-56-5 |
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中文名称 |
猫眼草黄素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (267.14 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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