Hederagenin 28-O-beta-D-glucopyranosyl ester Chemical Structure
CAS No. : 53931-25-2
规格
价格
是否有货
1 mg
¥2860
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5 mg
¥8570
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生物活性
Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H2O2-induced myocardial cell injury[1].
分子量
634.84
Formula
C36H58O9
CAS 号
53931-25-2
中文名称
常春苷元-28-BETA-D-吡喃葡萄糖苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Li S, et al. New triterpenoid saponins from Ilex cornuta and their protective effects against H2O2-induced myocardial cell injury. J Agric Food Chem. 2014 Jan 15;62(2):488-96.
Hederagenin is a triterpenoid saponin. It can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB Hederagenin can Exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antilipid peroxidation, antiplatelet aggregation, liver protection, antidepression, anti-inflammation.[1] In vitro:1) Hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. [1] 2) The EC50 of hederagenin is 39 ± 6 μM in A549 cancer cell line, but it’s inactive for DLD-1 cells. [2] 3) Hederagenin inhibited LPS-induced production of NO, PGE2and cytokines in cells.[3] 4) Hederagenin had an anti-edema effect on the CA-induced mouse hind paw edema assay. [3] 5) Hederagenin inhibited the CA-induced increase in skin thicknesses. [3] In vivo: The rats in the hederagenin group were administered hederagenin at 20 mg/kg/d via gavage.(More details please refer to the protocol below). In AS rat models induced by a high-lipid diet plus VD3, hederagenin can effectively reduce serum lipid, ALT, and AST levels, in addition to improving liver function, relieving high blood coagulation, and slowing blood flow and stasis by improving blood rheology. [1]
分子量
472.70
Formula
C30H48O4
CAS 号
465-99-6
中文名称
常春藤皂苷元
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Su-Hong Lu et al. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evid Based Complement Alternat Med, 2015, Oct 19
[2]. Diego Rodríguez-Hernández et al. Hederagenin as a triterpene template for the development of new antitumor compounds. Eur J Med Chem, 2015 Nov 13, 105:57-62
[3]. Chul Won Lee et al. Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice. Int Immunopharmacol, 2015 Dec, 29(2):528-37.