标签归档：acetate

Cresyl Violet acetate(Synonyms: 甲酚紫醋酸盐)

发表于由

Cresyl Violet acetate;(Synonyms: 甲酚紫醋酸盐) 纯度: ge;70.0%

Cresyl Violet acetate 是一种红色荧光染色剂，可用于染色神经元。

Cresyl Violet acetateamp;;(Synonyms: 甲酚紫醋酸盐)

Cresyl Violet acetate Chemical Structure

CAS No. : 10510-54-0

规格 价格 是否有货 数量
100 mg ￥500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Cresyl Violet acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Cresyl Violet acetate is a red fluorescent stain, which can be used to stain neurons.

体外研究
(In Vitro)

The estimated total number of SG neurons is 27,485±3251 and 26,705±1823 in the PV and Cresyl Violet acetate stained sections, respectively. There is no significant difference between them (p=0.552). Therefore, Cresyl Violet acetate staining is simpler and more cost effective when estimates neuronal number. Although PV stains spiral ganglion neurons (SGNs) with a greater intensity and provides a functional status, its tedious protocol limits its use for quantification. Total RC volume is estimated using probe and it is found that an average RC volume of 2.162±0.35 mm3 and 1.82±0.33 mm3 in Cresyl Violet acetate staining and PV immunostaining sections, respectively. Volume of neurons is estimated using nucleator probe and it is 3487.63±951 μm3 and 3740.1±784 μm3 in Cresyl Violet acetate staining and PV immunostaining sections, respectively. Similarly, volume of neuronal nucleus is also estimated using nucleator probe and it is found to be 131.68±50 μm3 and 126.51±33 μm3 in Cresyl Violet acetate staining and PV immunostaining sections, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

321.33

Formula

C18H15N3O3
CAS 号

10510-54-0
中文名称

甲酚紫醋酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 1 mg/mL (3.11 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1121 mL 15.5603 mL 31.1207 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kaur C, et al. Comparison of unbiased stereological estimation of total number of cresyl violet stained neurons and parvalbumin positive neurons in the adult human spiral ganglion. J Chem Neuroanat. 2017 Jun 23. pii: S0891-0618(17)30037-6.
Cell Assay
[1]

Cochlear sections containing SGNs are placed in 24 wells plates containing PBS (pH 7.4) and stored at 4°C. The sections are then used for Cresyl violet acetate and immunohistochemical (IHC) staining. Every 7th section is stained with Cresyl violet acetate (1%), dehydrated with ascending grades of alcohol, cleared with xylene, mounted with DPX and observed under microscope. Approximately 12-13 Cresyl violet acetate staining sections from each specimen are used for stereology. None of these cases show any histopathological changes under the light microscope. Estimation of the total volume of the Rosenthal canal (RC), total number of SGNs (optical fractionator probe) and the volume of the soma and their nucleus (nucleator probe) is done with software[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Kaur C, et al. Comparison of unbiased stereological estimation of total number of cresyl violet stained neurons and parvalbumin positive neurons in the adult human spiral ganglion. J Chem Neuroanat. 2017 Jun 23. pii: S0891-0618(17)30037-6.

Ziconotide acetate(Synonyms: SNX-111 acetate)

发表于由

Ziconotide acetate;(Synonyms: SNX-111 acetate) 纯度: 99.64%

Ziconotide acetate (SNX-111 acetate) 是一种肽，是一种有效且选择性的 N 型钙通道 (N-type calcium channels) 拮抗剂阻断剂。Ziconotide acetate 减少突触传递，并可用于慢性疼痛研究。

Ziconotide acetateamp;;(Synonyms: SNX-111 acetate)

Ziconotide acetate Chemical Structure

CAS No. : 914454-03-8

规格 价格 是否有货 数量
5 mg ￥5800 In-stock
10 mg ￥9000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Ziconotide acetate 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research[1].

IC50 Target[1]

N-Type Ca2+ Channel

;

体外研究
(In Vitro)

Most native cells express a variety of different calcium channels and as a result, Ziconotide acetate only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide acetate also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide acetate delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) acetate reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage: 25 pmol/site, 50 pmol/site, 100 pmol/site
Administration: Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result: Significantly reduced the mechanical hypersensitivity in animals with EAE.

Formula

C102H172N36O32S7.xC2H4O2
CAS 号

914454-03-8
Sequence

Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
中文名称

醋酸齐考诺肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (Need ultrasonic)

DMSO : 25 mg/mL (Need ultrasonic)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85.

    [2]. Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327.

Potassium acetate

发表于由

生化分析试剂 Biochemical Assay Reagents
Potassium acetate;

Potassium Acetate，一种钾盐，用于补充电解质，恢复水电解质平衡。Potassium Acetate 可用于 DNA 和蛋白质纯化。Potassium Acetate 用于制备细菌碱性裂解的中和液。

Potassium acetate

Potassium acetate Chemical Structure

CAS No. : 127-08-2

规格 价格 是否有货 数量
1 g ￥500 In-stock
5 g ￥800 In-stock
10 g ; 询价 ;
50 g ; 询价 ;

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Potassium acetate 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Metabolism/Protease Compound Library
  • FDA-Approved Drug Library
  • Human Endogenous Metabolite Compound Library
  • Fragment Library
  • Drug Repurposing Compound Library
  • NMPA-Approved Drug Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Inactive Ingredient Library

生物活性

Potassium acetate is a potassium salt employed to replenish electrolytes, for restoration of water-electrolyte balance. Potassium acetate can employ in DNA and protein purification. Potassium acetate has been used to prepare neutralizing solution for alkaline lysis of bacteria[1][2].

分子量

98.14

Formula

C2H3KO2
CAS 号

127-08-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
参考文献

  • [1]. Sokolov BP, et al. Vydelenie vysokomolekuliarnoĭ éukarioticheskoĭ DNK s ispol’zovaniem atsetata kaliia [Isolation of high molecular weight eukaryotic DNA with the use of potassium acetate]. Mol Gen Mikrobiol Virusol. 1989;(6):45-46.

    [2]. Shan G, et al. Purification of total DNA extracted from activated sludge. J Environ Sci (China). 2008;20(1):80-87.

Aviptadil acetate(Synonyms: 醋酸阿肽地尔 Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine))

发表于由

Aviptadil acetate;(Synonyms: 醋酸阿肽地尔; Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)) 纯度: 99.09%

Aviptadil acetate 是一种模拟血管活性肠多肽 (VIP) 类似物，具有强的血管舒张 (vasodilatory) 效应。。Aviptadil acetate 诱导肺血管扩张，抑制血管 SMCs 增殖、血小板聚集。Aviptadil acetate 可用于肺纤维化、肺动脉高压 (PAH)、SARS-CoV-2 引起呼吸衰竭等的研究。

Aviptadil acetateamp;;(Synonyms: 醋酸阿肽地尔; Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine))

Aviptadil acetate Chemical Structure

CAS No. : 1444827-29-5

规格 价格 是否有货 数量
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Aviptadil acetate 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • FDA-Approved Drug Library
  • Antiviral Compound Library
  • Drug Repurposing Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Rare Diseases Drug Library
  • Peptide Library

生物活性

Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al[1].

体外研究
(In Vitro)

Aviptadil acetate inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner[3].
Aviptadil acetate (1 nM-10 μM) produces a concentration-dependent inhibition of CSE-induced cell death in L2 cells. At 10 μM, Aviptadil acetate reduces CSE-stimulated MMP activity and caspase-3 activation in L2 cells[1].
Aviptadil acetate (10 nM-100 μM) attenuates lipopolisaccharide (LPS)-induced MMP-9 activity and its expression by alveolar macrophages (AM) in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Aviptadil acetate (1, 3 and 10 mg/kg; intravenous bolus injection) is injected into a tail vein. No-effect dose level is 1 mg/kg. Dose level with first intolerance reactions 3 mg/kg, Lowest lethal dose level is >10 mg/kg. i.v. LD50 of Aviptadil is >10 mg/kg in males, females and male and female combined after 24 hours and 14 days[3].
Aviptadil acetate (intravenous bolus injection) at 3 mg causes slightly reduced motility, slight ataxia and slight dyspnoea in all 5 male and 5 female animals 15 to 30 minutes after administration. At 10 mg, Aviptadil reveals slightly reduced motility, slight ataxia, and slight dyspnoea 15 to 60 minutes and slightly reduces muscle tone 15 to 30 minutes after administration, respectively, in all male and female animals[3].
Nose-only inhalation exposure of CD1 mice to aerosolized.
Aviptadil acetate at a dose of 1546 µg/kg/day is well tolerated and produces no apparent changes in any of the parameters evaluated. No changes are observed after a single dose administration as high as 3920 µg/kg/day. The no-observable-adverse-effect level (NOAEL) is considered to be at least 3920 µg/kg/day fore an acute exposure and 1546 µg/kg/day for a 10 day repeated exposure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

3385.90

Formula

C147H238N44O42S.C2H4O2
CAS 号

1444827-29-5
Sequence Shortening

HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2
中文名称

醋酸阿肽地尔；醋酸阿维他定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (29.53 mM; Need ultrasonic)

DMSO : 100 mg/mL (29.53 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2953 mL 1.4767 mL 2.9534 mL
5 mM 0.0591 mL 0.2953 mL 0.5907 mL
10 mM 0.0295 mL 0.1477 mL 0.2953 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (0.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (0.74 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (0.74 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (0.74 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (0.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (0.74 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)

    [2]. Jian Hu, et al. Novel Targets of Drug Treatment for Pulmonary Hypertension. Am J Cardiovasc Drugs

    [3]. INVESTIGATOR’S BROCHURE Sponsor: NeuroRx, Inc

Magnesium acetate tetrahydrate

发表于由

生化分析试剂 Biochemical Assay Reagents
Magnesium acetate tetrahydrate;

Magnesium acetate tetrahydrate 是无水醋酸镁盐的水合形式。作为镁的盐形式，乙酸镁是镁的生物可利用形式之一，并形成非常水溶性的化合物。Magnesium acetate tetrahydrate 可作为电解质补充剂或分子生物学实验中的试剂。

Magnesium acetate tetrahydrate

Magnesium acetate tetrahydrate Chemical Structure

CAS No. : 16674-78-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Magnesium acetate tetrahydrate 的其他形式现货产品:

Potassium acetate

生物活性

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt. As a salt form of Magnesium, Magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments[1].

IC50 Target

Microbial Metabolite

;

Human Endogenous Metabolite

;

分子量

214.45

Formula

C4H14MgO8
CAS 号

16674-78-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Krisztian Nemeth, et al. Synthesis and investigation of SiO 2-MgO coated MWCNTs and their potential application. Sci Rep. 2019 Oct 22;9(1):15113.

8-Epidiosbulbin E acetate(Synonyms: 8-表黄药子素E乙酸酯)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

8-Epidiosbulbin E acetate (Synonyms: 8-表黄药子素E乙酸酯) 纯度: 98.02%

8-Epidiosbulbin E acetate 是 Dioscorea bulbifera L. 中存在的丰富的呋喃型化合物，8-Epidiosbulbin E acetate 对多重耐药菌具有广谱的质粒消除活性。8-Epidiosbulbin E acetate 能诱导小鼠肝损伤。

8-Epidiosbulbin E acetate(Synonyms: 8-表黄药子素E乙酸酯)

8-Epidiosbulbin E acetate Chemical Structure

CAS No. : 91095-48-6

规格 价格 是否有货 数量
1 mg ￥1700 In-stock
5 mg ￥3500 In-stock
10 mg ￥5950 In-stock
25 mg ￥12500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

8-Epidiosbulbin E acetate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Antibacterial Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Animal Disease Model Inducer Library

生物活性

8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].

分子量

388.41

Formula

C21H24O7
CAS 号

91095-48-6
中文名称

8-表黄药子素E乙酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (257.46 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5746 mL 12.8730 mL 25.7460 mL
5 mM 0.5149 mL 2.5746 mL 5.1492 mL
10 mM 0.2575 mL 1.2873 mL 2.5746 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.44 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.44 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.44 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Shriram V, et al. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria. Int J Antimicrob Agents. 2008 Nov;32(5):405-10.

    [2]. Lin D, et al. Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. Chem Res Toxicol. 2016 Mar 21;29(3):359-66.

Nonapeptide-1 acetate salt(Synonyms: Melanostatine-5 acetate salt)

发表于由

Nonapeptide-1 acetate salt;(Synonyms: Melanostatine-5 acetate salt) 纯度: 99.76%

Nonapeptide-1 acetate salt 是一种多肽激素，是强效的 α-黑色素细胞刺激激素 (α-MSH) 的拮抗剂，其 IC50 值为 11 nM。减少黑色素的合成，在很大程度上帮助减少皮肤色素沉着。

Nonapeptide-1 acetate saltamp;;(Synonyms: Melanostatine-5 acetate salt)

Nonapeptide-1 acetate salt Chemical Structure

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥4460 In-stock
1 mg ￥800 In-stock
5 mg ￥2200 In-stock
10 mg ￥3200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Nonapeptide-1 acetate salt 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Macrocyclic Compound Library
  • Endocrinology Compound Library
  • Peptide Library

生物活性

Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree[1].

IC50 Target

IC50: 11 nM (α-MSH)[1].
分子量

1266.56

Formula

C63H91N15O11S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 50 mg/mL (39.48 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7895 mL 3.9477 mL 7.8954 mL
5 mM 0.1579 mL 0.7895 mL 1.5791 mL
10 mM 0.0790 mL 0.3948 mL 0.7895 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54.

Thionin Acetate 硫堇(劳氏紫) 品牌：FUJIFILM Wako

发表于由

Thionin Acetate

硫堇(劳氏紫)

品牌：FUJIFILM Wako
CAS No.：78338-22-4
储存条件：室温
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

208-18611

 for Pathology Research 5g – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

(+)-Columbianetin acetate(Synonyms: (S)-Columbianetin acetate)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

(+)-Columbianetin acetate (Synonyms: (S)-Columbianetin acetate) 纯度: 99.71%

(S)-Columbianetin acetate 是 Columbianetin 的一个异构体。Columbianetin 是一种植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关。Columbianetin 具有良好的抗真菌和抗炎活性。

(+)-Columbianetin acetate(Synonyms: (S)-Columbianetin acetate)

(+)-Columbianetin acetate Chemical Structure

CAS No. : 23180-65-6

规格 价格 是否有货 数量
5 mg ￥1190 In-stock
10 mg ￥2020 In-stock
20 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

(+)-Columbianetin acetate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library

生物活性

(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity[1][2].

分子量

288.30

Formula

C16H16O5
CAS 号

23180-65-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (346.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4686 mL 17.3430 mL 34.6861 mL
5 mM 0.6937 mL 3.4686 mL 6.9372 mL
10 mM 0.3469 mL 1.7343 mL 3.4686 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.67 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.67 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.67 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.67 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. UziAfek, et al. Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage. 1995. Volume 39, Issue 6, August 1995, Pages 1347-1350.

    [2]. Jeong HJ, et al. Anti-inflammatory effect of Columbianetin on activated human mast cells. Biol Pharm Bull. 2009 Jun;32(6):1027-31.

Thionin Acetate 硫堇(劳氏紫) 品牌：FUJIFILM Wako

发表于由

Thionin Acetate

硫堇(劳氏紫)

品牌：FUJIFILM Wako
CAS No.：78338-22-4
储存条件：室温
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

206-18612

 for Pathology Research 25g – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。