标签归档：cinnamoylcatalpol

Picroside I(Synonyms: 6′-Cinnamoylcatalpol)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Picroside I;(Synonyms: 6′-Cinnamoylcatalpol) 纯度: 96.57%

Picroside I (6′-Cinnamoylcatalpol) 是 Picrorhiza kurroa 的一种主要成分。Picrorhiza kurroa 是一种高价值的药用植物，富含肝脏保护代谢物 Picroside I 和 Picroside-II。Picroside I 可用于哮喘研究。Picroside I 可显著减轻炎症。Picroside I 还下调 pSTAT6 和 GATA3 表达。Picroside I 剂量依赖性地增加血清 IFN-γ 水平。

Picroside I(Synonyms: 6

Picroside I Chemical Structure

CAS No. : 27409-30-9

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥542 In-stock
5 mg ￥500 In-stock
10 mg ￥800 In-stock
20 mg ￥1400 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Picroside I 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
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  • Immunology/Inflammation Compound Library
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生物活性

Picroside I is the major ingredient of Picrorhiza kurroa. Picrorhiza kurroa is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2].

IC50 Target

STAT6

;

分子量

492.47

Formula

C24H28O11
CAS 号

27409-30-9
中文名称

胡黄连苷 I
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (507.65 mM; Need ultrasonic)

H2O : 125 mg/mL (253.82 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0306 mL 10.1529 mL 20.3058 mL
5 mM 0.4061 mL 2.0306 mL 4.0612 mL
10 mM 0.2031 mL 1.0153 mL 2.0306 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56.

    [2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.