-SulfoBiotics-Sodium disulfide (Na2S2) 体内硫磺供体SulfoBiotics-二硫化钠(Na2S2) 品牌：Dojindo

发表于2024年3月17日由Whatman官网

-SulfoBiotics-Sodium disulfide (Na2S2)

体内硫磺供体SulfoBiotics-二硫化钠(Na2S2)

品牌：Dojindo
CAS No.：22868-13-9
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
344-91761	–	1 Set	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Transdermal Peptide Disulfide TFA(Synonyms: TD 1 Disulfide(peptide) TFA)

发表于2024年3月16日由Whatman官网

Transdermal Peptide Disulfide TFA;(Synonyms: TD 1 Disulfide(peptide) TFA) 纯度: 98.45%

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) 是由 11 个氨基酸组成的多肽，可以与 Na⁺/K⁺-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide TFA 能够增强一些大分子在皮肤中的传递。

Transdermal Peptide Disulfide TFAamp;;(Synonyms: TD 1 Disulfide(peptide) TFA)

Transdermal Peptide Disulfide TFA Chemical Structure

规格	价格	是否有货	数量
1 mg	￥800	In-stock
5 mg	￥1800	In-stock
10 mg	￥2800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Transdermal Peptide Disulfide TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Macrocyclic Compound Library
Peptide Library

生物活性

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules^[1].

体外研究
(In Vitro)

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1175.17

Formula

C₄₂H₆₅F₃N₁₄O₁₈S₂

Sequence Shortening

ACSSSPSKHCG (Disulfide bridge: Cys2-Cys10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 100 mg/mL (85.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8509 mL	4.2547 mL	8.5094 mL
5 mM	0.1702 mL	0.8509 mL	1.7019 mL
10 mM	0.0851 mL	0.4255 mL	0.8509 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.

Transdermal Peptide Disulfide(Synonyms: TD 1 Disulfide(peptide))

发表于2024年2月13日由Whatman官网

Transdermal Peptide Disulfide;(Synonyms: TD 1 Disulfide(peptide))

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) 是由 11 个氨基酸组成的多肽，可以与 Na⁺/K⁺-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide 能够增强一些大分子在皮肤中的传递。

Transdermal Peptide Disulfideamp;;(Synonyms: TD 1 Disulfide(peptide))

Transdermal Peptide Disulfide Chemical Structure

CAS No. : 888486-23-5

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Transdermal Peptide Disulfide 的其他形式现货产品:

Transdermal Peptide Disulfide TFA

生物活性

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules^[1].

体外研究
(In Vitro)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1061.15

Formula

C₄₀H₆₄N₁₄O₁₆S₂

CAS 号

888486-23-5

Sequence

Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly (Disulfide bridge:Cys2-Cys10)

Sequence Shortening

ACSSSPSKHCG (Disulfide bridge:Cys2-Cys10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.